{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:20:24Z","timestamp":1778858424271,"version":"3.51.4"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Objective\u2014<\/jats:italic>\n            <\/jats:bold>\n            To determine whether plasma triglyceride levels in adult Glycosylphosphatidylinositol HDL-binding protein 1 (GPIHBP1)-deficient (\n            <jats:italic>Gpihbp1<\/jats:italic>\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            ) mice would be sensitive to cholesterol intake.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods and Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            Gpihbp1\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            mice were fed a Western diet containing 0.15% cholesterol. After 4 to 8 weeks, their plasma triglyceride levels were 113 to 135 mmol\/L. When 0.005% ezetimibe was added to the diet to block cholesterol absorption,\n            <jats:italic>Lpl<\/jats:italic>\n            expression in the liver was reduced significantly, and the plasma triglyceride levels were significantly higher (&gt;170 mmol\/L). We also assessed plasma triglyceride levels in\n            <jats:italic>Gpihbp1<\/jats:italic>\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            mice fed Western diets containing either high (1.3%) or low (0.05%) amounts of cholesterol. The high-cholesterol diet significantly increased\n            <jats:italic>Lpl<\/jats:italic>\n            expression in the liver and lowered plasma triglyceride levels.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusion\u2014<\/jats:italic>\n            <\/jats:bold>\n            Treatment of\n            <jats:italic>Gpihbp1<\/jats:italic>\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            mice with ezetimibe lowers\n            <jats:italic>Lpl<\/jats:italic>\n            expression in the liver and increases plasma triglyceride levels. A high-cholesterol diet had the opposite effects. Thus, cholesterol intake modulates plasma triglyceride levels in\n            <jats:italic>Gpihbp1<\/jats:italic>\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            mice.\n          <\/jats:p>","DOI":"10.1161\/atvbaha.110.214403","type":"journal-article","created":{"date-parts":[[2010,9,3]],"date-time":"2010-09-03T02:43:02Z","timestamp":1283481782000},"page":"2106-2113","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["Cholesterol Intake Modulates Plasma Triglyceride Levels in Glycosylphosphatidylinositol HDL-Binding Protein 1-Deficient Mice"],"prefix":"10.1161","volume":"30","author":[{"given":"Michael M.","family":"Weinstein","sequence":"first","affiliation":[{"name":"From the Department of Medicine (M.M.W., Y.T., A.P.B., B.S.J.D., P.G., C.V., L.G.F., and S.G.Y.), David Geffen School of Medicine, University of California, Los Angeles; the Department of Human Genetics (M.M.W., K.R., and S.G.Y.), David Geffen School of Medicine, University of California, Los Angeles; the Department of Poultry Science and Nutrition and Food Science (R.L.W.), Texas A&amp;M University, College Station, Tex; the Department of Pathology and Laboratory Medicine (P.T.), David Geffen..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiping","family":"Tu","sequence":"additional","affiliation":[{"name":"From the Department of Medicine (M.M.W., Y.T., A.P.B., B.S.J.D., P.G., C.V., L.G.F., and S.G.Y.), David Geffen School of Medicine, University of California, Los Angeles; the Department of Human Genetics (M.M.W., K.R., and S.G.Y.), David Geffen School of Medicine, University of California, Los Angeles; the Department of Poultry Science and Nutrition and Food Science (R.L.W.), Texas A&amp;M University, College Station, Tex; the Department of Pathology and Laboratory Medicine (P.T.), David Geffen..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne P.","family":"Beigneux","sequence":"additional","affiliation":[{"name":"From the Department of Medicine (M.M.W., Y.T., A.P.B., B.S.J.D., P.G., C.V., L.G.F., and S.G.Y.), David Geffen School of Medicine, University of California, Los Angeles; the Department of Human Genetics (M.M.W., K.R., and S.G.Y.), David Geffen School of Medicine, University of California, Los Angeles; the Department of Poultry Science and Nutrition and Food Science (R.L.W.), Texas A&amp;M University, College Station, Tex; the Department of Pathology and Laboratory Medicine (P.T.), David Geffen..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandon S.J.","family":"Davies","sequence":"additional","affiliation":[{"name":"From the Department of Medicine (M.M.W., Y.T., A.P.B., B.S.J.D., P.G., C.V., L.G.F., and S.G.Y.), David Geffen School of Medicine, University of California, Los Angeles; the Department of Human Genetics (M.M.W., K.R., and S.G.Y.), David Geffen School of Medicine, University of California, Los Angeles; the Department of Poultry Science and Nutrition and Food Science (R.L.W.), Texas A&amp;M University, College Station, Tex; the Department of Pathology and Laboratory Medicine (P.T.), David Geffen..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Gin","sequence":"additional","affiliation":[{"name":"From the Department of Medicine (M.M.W., Y.T., A.P.B., B.S.J.D., P.G., C.V., L.G.F., and S.G.Y.), David Geffen School of Medicine, University of California, Los Angeles; the Department of Human Genetics (M.M.W., K.R., and S.G.Y.), David Geffen School of Medicine, University of California, Los Angeles; the Department of Poultry Science and Nutrition and Food Science (R.L.W.), Texas A&amp;M University, College Station, Tex; the Department of Pathology and Laboratory Medicine (P.T.), David Geffen..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constance","family":"Voss","sequence":"additional","affiliation":[{"name":"From the Department of Medicine (M.M.W., Y.T., A.P.B., B.S.J.D., P.G., C.V., L.G.F., and S.G.Y.), David Geffen School of Medicine, University of California, Los Angeles; the Department of Human Genetics (M.M.W., K.R., and S.G.Y.), David Geffen School of Medicine, University of California, Los Angeles; the Department of Poultry Science and Nutrition and Food Science (R.L.W.), Texas A&amp;M University, College Station, Tex; the Department of Pathology and Laboratory Medicine (P.T.), David Geffen..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosemary L.","family":"Walzem","sequence":"additional","affiliation":[{"name":"From the Department of Medicine (M.M.W., Y.T., A.P.B., B.S.J.D., P.G., C.V., L.G.F., and S.G.Y.), David Geffen School of Medicine, University of California, Los Angeles; the Department of Human Genetics (M.M.W., K.R., and S.G.Y.), David Geffen School of Medicine, University of California, Los Angeles; the Department of Poultry Science and Nutrition and Food Science (R.L.W.), Texas A&amp;M University, College Station, Tex; the Department of Pathology and Laboratory Medicine (P.T.), David Geffen..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Reue","sequence":"additional","affiliation":[{"name":"From the Department of Medicine (M.M.W., Y.T., A.P.B., B.S.J.D., P.G., C.V., L.G.F., and S.G.Y.), David Geffen School of Medicine, University of California, Los Angeles; the Department of Human Genetics (M.M.W., K.R., and S.G.Y.), David Geffen School of Medicine, University of California, Los Angeles; the Department of Poultry Science and Nutrition and Food Science (R.L.W.), Texas A&amp;M University, College Station, Tex; the Department of Pathology and Laboratory Medicine (P.T.), David Geffen..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Tontonoz","sequence":"additional","affiliation":[{"name":"From the Department of Medicine (M.M.W., Y.T., A.P.B., B.S.J.D., P.G., C.V., L.G.F., and S.G.Y.), David Geffen School of Medicine, University of California, Los Angeles; the Department of Human Genetics (M.M.W., K.R., and S.G.Y.), David Geffen School of Medicine, University of California, Los Angeles; the Department of Poultry Science and Nutrition and Food Science (R.L.W.), Texas A&amp;M University, College Station, Tex; the Department of Pathology and Laboratory Medicine (P.T.), David Geffen..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andre\u0301","family":"Bensadoun","sequence":"additional","affiliation":[{"name":"From the Department of Medicine (M.M.W., Y.T., A.P.B., B.S.J.D., P.G., C.V., L.G.F., and S.G.Y.), David Geffen School of Medicine, University of California, Los Angeles; the Department of Human Genetics (M.M.W., K.R., and S.G.Y.), David Geffen School of Medicine, University of California, Los Angeles; the Department of Poultry Science and Nutrition and Food Science (R.L.W.), Texas A&amp;M University, College Station, Tex; the Department of Pathology and Laboratory Medicine (P.T.), David Geffen..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loren G.","family":"Fong","sequence":"additional","affiliation":[{"name":"From the Department of Medicine (M.M.W., Y.T., A.P.B., B.S.J.D., P.G., C.V., L.G.F., and S.G.Y.), David Geffen School of Medicine, University of California, Los Angeles; the Department of Human Genetics (M.M.W., K.R., and S.G.Y.), David Geffen School of Medicine, University of California, Los Angeles; the Department of Poultry Science and Nutrition and Food Science (R.L.W.), Texas A&amp;M University, College Station, Tex; the Department of Pathology and Laboratory Medicine (P.T.), David Geffen..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen G.","family":"Young","sequence":"additional","affiliation":[{"name":"From the Department of Medicine (M.M.W., Y.T., A.P.B., B.S.J.D., P.G., C.V., L.G.F., and S.G.Y.), David Geffen School of Medicine, University of California, Los Angeles; the Department of Human Genetics (M.M.W., K.R., and S.G.Y.), David Geffen School of Medicine, University of California, Los Angeles; the Department of Poultry Science and Nutrition and Food Science (R.L.W.), Texas A&amp;M University, College Station, Tex; the Department of Pathology and Laboratory Medicine (P.T.), David Geffen..."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_1_2","unstructured":"Havel RJ Kane JP. 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