{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T16:39:29Z","timestamp":1769013569881,"version":"3.49.0"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:sec>\n            <jats:title>Objective\u2014<\/jats:title>\n            <jats:p>\n              Cyclophilin A (CyPA, encoded by\n              <jats:italic>Ppia<\/jats:italic>\n              ) is a proinflammatory protein secreted in response to oxidative stress in mice and humans. We recently demonstrated that CyPA increased angiotensin II (Ang II)\u2013induced reactive oxygen species (ROS) production in the aortas of apolipoprotein E (\n              <jats:italic>Apoe<\/jats:italic>\n              )\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              mice. In this study, we sought to evaluate the role of CyPA in Ang II\u2013induced cardiac hypertrophy.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              Cardiac hypertrophy was not significantly different between\n              <jats:italic>Ppia<\/jats:italic>\n              <jats:sup>+\/+<\/jats:sup>\n              and\n              <jats:italic>Ppia<\/jats:italic>\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              mice infused with Ang II (1000 ng\/min per kg for 4 weeks). Therefore, we investigated the effect of CyPA under conditions of high ROS and inflammation using the\n              <jats:italic>Apoe<\/jats:italic>\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              mice. In contrast to\n              <jats:italic>Apoe<\/jats:italic>\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              mice,\n              <jats:italic>Apoe<\/jats:italic>\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              <jats:italic>Ppia<\/jats:italic>\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              mice exhibited significantly less Ang II\u2013induced cardiac hypertrophy. Bone marrow cell transplantation showed that CyPA in cells intrinsic to the heart plays an important role in the cardiac hypertrophic response. Ang II\u2013induced ROS production, cardiac fibroblast proliferation, and cardiac fibroblast migration were markedly decreased in\n              <jats:italic>Apoe<\/jats:italic>\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              <jats:italic>Ppia<\/jats:italic>\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              cardiac fibroblasts. Furthermore, CyPA directly induced the hypertrophy of cultured neonatal cardiac myocytes.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion\u2014<\/jats:title>\n            <jats:p>CyPA is required for Ang II\u2013mediated cardiac hypertrophy by directly potentiating ROS production, stimulating the proliferation and migration of cardiac fibroblasts, and promoting cardiac myocyte hypertrophy.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/atvbaha.110.214601","type":"journal-article","created":{"date-parts":[[2011,2,18]],"date-time":"2011-02-18T04:19:26Z","timestamp":1298002766000},"page":"1116-1123","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":73,"title":["Cyclophilin A Promotes Cardiac Hypertrophy in Apolipoprotein E\u2013Deficient Mice"],"prefix":"10.1161","volume":"31","author":[{"given":"Kimio","family":"Satoh","sequence":"first","affiliation":[{"name":"From the Aab Cardiovascular Research Institute (K.S., P.N., A.Z., N.N.S., F.J., M.O., M.R.O., Z.C., P.M., Y.L., A.M., C.Y., B.C. Blaxall, B.C. Berk) and Department of Medicine (K.S., P.N., A.Z., N.N.S., F.J., M.O., M.R.O., Z.C., P.M., Y.L., A.M., C.Y., B.C. Blaxall, B.C. Berk), University of Rochester School of Medicine and Dentistry, Rochester, NY; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan (K.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Nigro","sequence":"additional","affiliation":[{"name":"From the Aab Cardiovascular Research Institute (K.S., P.N., A.Z., N.N.S., F.J., M.O., M.R.O., Z.C., P.M., Y.L., A.M., C.Y., B.C. Blaxall, B.C. Berk) and Department of Medicine (K.S., P.N., A.Z., N.N.S., F.J., M.O., M.R.O., Z.C., P.M., Y.L., A.M., C.Y., B.C. Blaxall, B.C. Berk), University of Rochester School of Medicine and Dentistry, Rochester, NY; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan (K.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asad","family":"Zeidan","sequence":"additional","affiliation":[{"name":"From the Aab Cardiovascular Research Institute (K.S., P.N., A.Z., N.N.S., F.J., M.O., M.R.O., Z.C., P.M., Y.L., A.M., C.Y., B.C. Blaxall, B.C. Berk) and Department of Medicine (K.S., P.N., A.Z., N.N.S., F.J., M.O., M.R.O., Z.C., P.M., Y.L., A.M., C.Y., B.C. Blaxall, B.C. Berk), University of Rochester School of Medicine and Dentistry, Rochester, NY; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan (K.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nwe Nwe","family":"Soe","sequence":"additional","affiliation":[{"name":"From the Aab Cardiovascular Research Institute (K.S., P.N., A.Z., N.N.S., F.J., M.O., M.R.O., Z.C., P.M., Y.L., A.M., C.Y., B.C. Blaxall, B.C. Berk) and Department of Medicine (K.S., P.N., A.Z., N.N.S., F.J., M.O., M.R.O., Z.C., P.M., Y.L., A.M., C.Y., B.C. Blaxall, B.C. Berk), University of Rochester School of Medicine and Dentistry, Rochester, NY; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan (K.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrice","family":"Jaffr\u00e9","sequence":"additional","affiliation":[{"name":"From the Aab Cardiovascular Research Institute (K.S., P.N., A.Z., N.N.S., F.J., M.O., M.R.O., Z.C., P.M., Y.L., A.M., C.Y., B.C. Blaxall, B.C. Berk) and Department of Medicine (K.S., P.N., A.Z., N.N.S., F.J., M.O., M.R.O., Z.C., P.M., Y.L., A.M., C.Y., B.C. Blaxall, B.C. Berk), University of Rochester School of Medicine and Dentistry, Rochester, NY; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan (K.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayoshi","family":"Oikawa","sequence":"additional","affiliation":[{"name":"From the Aab Cardiovascular Research Institute (K.S., P.N., A.Z., N.N.S., F.J., M.O., M.R.O., Z.C., P.M., Y.L., A.M., C.Y., B.C. Blaxall, B.C. Berk) and Department of Medicine (K.S., P.N., A.Z., N.N.S., F.J., M.O., M.R.O., Z.C., P.M., Y.L., A.M., C.Y., B.C. Blaxall, B.C. Berk), University of Rochester School of Medicine and Dentistry, Rochester, NY; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan (K.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R.","family":"O'Dell","sequence":"additional","affiliation":[{"name":"From the Aab Cardiovascular Research Institute (K.S., P.N., A.Z., N.N.S., F.J., M.O., M.R.O., Z.C., P.M., Y.L., A.M., C.Y., B.C. Blaxall, B.C. Berk) and Department of Medicine (K.S., P.N., A.Z., N.N.S., F.J., M.O., M.R.O., Z.C., P.M., Y.L., A.M., C.Y., B.C. Blaxall, B.C. Berk), University of Rochester School of Medicine and Dentistry, Rochester, NY; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan (K.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoqiang","family":"Cui","sequence":"additional","affiliation":[{"name":"From the Aab Cardiovascular Research Institute (K.S., P.N., A.Z., N.N.S., F.J., M.O., M.R.O., Z.C., P.M., Y.L., A.M., C.Y., B.C. Blaxall, B.C. Berk) and Department of Medicine (K.S., P.N., A.Z., N.N.S., F.J., M.O., M.R.O., Z.C., P.M., Y.L., A.M., C.Y., B.C. Blaxall, B.C. Berk), University of Rochester School of Medicine and Dentistry, Rochester, NY; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan (K.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prashanthi","family":"Menon","sequence":"additional","affiliation":[{"name":"From the Aab Cardiovascular Research Institute (K.S., P.N., A.Z., N.N.S., F.J., M.O., M.R.O., Z.C., P.M., Y.L., A.M., C.Y., B.C. Blaxall, B.C. Berk) and Department of Medicine (K.S., P.N., A.Z., N.N.S., F.J., M.O., M.R.O., Z.C., P.M., Y.L., A.M., C.Y., B.C. Blaxall, B.C. Berk), University of Rochester School of Medicine and Dentistry, Rochester, NY; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan (K.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Lu","sequence":"additional","affiliation":[{"name":"From the Aab Cardiovascular Research Institute (K.S., P.N., A.Z., N.N.S., F.J., M.O., M.R.O., Z.C., P.M., Y.L., A.M., C.Y., B.C. Blaxall, B.C. Berk) and Department of Medicine (K.S., P.N., A.Z., N.N.S., F.J., M.O., M.R.O., Z.C., P.M., Y.L., A.M., C.Y., B.C. Blaxall, B.C. Berk), University of Rochester School of Medicine and Dentistry, Rochester, NY; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan (K.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Mohan","sequence":"additional","affiliation":[{"name":"From the Aab Cardiovascular Research Institute (K.S., P.N., A.Z., N.N.S., F.J., M.O., M.R.O., Z.C., P.M., Y.L., A.M., C.Y., B.C. Blaxall, B.C. Berk) and Department of Medicine (K.S., P.N., A.Z., N.N.S., F.J., M.O., M.R.O., Z.C., P.M., Y.L., A.M., C.Y., B.C. Blaxall, B.C. Berk), University of Rochester School of Medicine and Dentistry, Rochester, NY; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan (K.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Yan","sequence":"additional","affiliation":[{"name":"From the Aab Cardiovascular Research Institute (K.S., P.N., A.Z., N.N.S., F.J., M.O., M.R.O., Z.C., P.M., Y.L., A.M., C.Y., B.C. Blaxall, B.C. Berk) and Department of Medicine (K.S., P.N., A.Z., N.N.S., F.J., M.O., M.R.O., Z.C., P.M., Y.L., A.M., C.Y., B.C. Blaxall, B.C. Berk), University of Rochester School of Medicine and Dentistry, Rochester, NY; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan (K.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burns C.","family":"Blaxall","sequence":"additional","affiliation":[{"name":"From the Aab Cardiovascular Research Institute (K.S., P.N., A.Z., N.N.S., F.J., M.O., M.R.O., Z.C., P.M., Y.L., A.M., C.Y., B.C. Blaxall, B.C. Berk) and Department of Medicine (K.S., P.N., A.Z., N.N.S., F.J., M.O., M.R.O., Z.C., P.M., Y.L., A.M., C.Y., B.C. Blaxall, B.C. Berk), University of Rochester School of Medicine and Dentistry, Rochester, NY; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan (K.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradford C.","family":"Berk","sequence":"additional","affiliation":[{"name":"From the Aab Cardiovascular Research Institute (K.S., P.N., A.Z., N.N.S., F.J., M.O., M.R.O., Z.C., P.M., Y.L., A.M., C.Y., B.C. Blaxall, B.C. Berk) and Department of Medicine (K.S., P.N., A.Z., N.N.S., F.J., M.O., M.R.O., Z.C., P.M., Y.L., A.M., C.Y., B.C. Blaxall, B.C. Berk), University of Rochester School of Medicine and Dentistry, Rochester, NY; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan (K.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0698-661"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.109.207456"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.209809"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05094.x"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.108.180976"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6238408"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M704934200"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070193"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.87.9.789"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.03.021"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1958"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcibr0905244"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00287.2006"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.73.3.413"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.8.794"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2009.04.004"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000254415.31362.a7"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2005.02.024"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.756106"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.105.583732"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000093660.86242.BB"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.0000181759.63239.21"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.74.6.1141"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1995.269.3.E426"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/hy1101.099484"},{"issue":"3","key":"e_1_3_4_27_2","first-page":"25","article-title":"Myocardial fibrosis: role of ventricular systolic pressure, arterial hypertension, and circulating hormones","volume":"86","author":"Weber KT","year":"1991","unstructured":"Weber KT, Brilla CG, Janicki JS, Reddy HK, Campbell SE. Myocardial fibrosis: role of ventricular systolic pressure, arterial hypertension, and circulating hormones. Basic Res Cardiol. 1991; 86 (suppl 3): 25\u201331.","journal-title":"Basic Res Cardiol"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.109.908319"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.07.005"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(98)00121-7"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000159937.05502.d1"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.2.12.1081"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199424050-00005"}],"container-title":["Arteriosclerosis, Thrombosis, and Vascular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/ATVBAHA.110.214601","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T23:15:42Z","timestamp":1715555742000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/ATVBAHA.110.214601"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["10.1161\/ATVBAHA.110.214601"],"URL":"https:\/\/doi.org\/10.1161\/atvbaha.110.214601","relation":{},"ISSN":["1079-5642","1524-4636"],"issn-type":[{"value":"1079-5642","type":"print"},{"value":"1524-4636","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5]]},"assertion":[{"value":"2010-08-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-01-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-02-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}