{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:33:18Z","timestamp":1792168398733,"version":"4.4.0"},"reference-count":48,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:sec>\n            <jats:title>Objective\u2014<\/jats:title>\n            <jats:p>To compare the effects of rosiglitazone (8 mg\/d, n=19) and metformin (2 g\/d, n=18) on postprandial lipemia in patients with HIV-lipodystrophy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              Lipodystrophy in HIV is associated with insulin resistance and disturbed postprandial triglyceride and free fatty acid (FFA) metabolism. We conducted an open randomized 6-month study with standardized 10-h oral fat-loading tests at baseline and after treatment. Rosiglitazone (\u221234%) and metformin (\u221237%) reduced homeostasis model assessment similarly (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05). Rosiglitazone did not change the area under the curve for FFA and triglyceride; however, it did reduce the area under the curve for hydroxybutyric acid (a marker of hepatic FFA oxidation) by 25% (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05). Rosiglitazone increased the area under the curve for remnantlike particle cholesterol by 40% (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01) compared with baseline. Metformin did not change any of the postprandial measurements.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion\u2014<\/jats:title>\n            <jats:p>Rosiglitazone improved insulin sensitivity and decreased postprandial hydroxybutyric acid levels in patients with HIV-lipodystrophy, suggesting improved FFA handling. Despite metabolic improvements, rosiglitazone caused a marked increase in postprandial remnantlike particle cholesterol, which may adversely affect cardiovascular risk. Metformin did not affect postprandial lipemia and could be used to treat insulin resistance in this population.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/atvbaha.110.216192","type":"journal-article","created":{"date-parts":[[2010,10,15]],"date-time":"2010-10-15T01:06:25Z","timestamp":1287104785000},"page":"228-233","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Differential Effects of Rosiglitazone and Metformin on Postprandial Lipemia in Patients With HIV-Lipodystrophy"],"prefix":"10.1161","volume":"31","author":[{"given":"Jeroen P.H.","family":"van Wijk","sequence":"first","affiliation":[{"name":"From the Department of Internal Medicine and Infectious Diseases (J.P.H.v.W. and I.M.H.), University Medical Center, Utrecht, the Netherlands; the Department of Nephrology (E.J.P.d.K. and T.J.R.), University Medical Center, Leiden, the Netherlands; the Department of Vascular Medicine (G.M.D.-T.), Academic Medical Center, Amsterdam, the Netherlands; and the Department of Internal Medicine (M.C.C.), Center for Diabetes and Vascular Medicine, St Franciscus Gasthuis, Rotterdam, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andy I.M.","family":"Hoepelman","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine and Infectious Diseases (J.P.H.v.W. and I.M.H.), University Medical Center, Utrecht, the Netherlands; the Department of Nephrology (E.J.P.d.K. and T.J.R.), University Medical Center, Leiden, the Netherlands; the Department of Vascular Medicine (G.M.D.-T.), Academic Medical Center, Amsterdam, the Netherlands; and the Department of Internal Medicine (M.C.C.), Center for Diabetes and Vascular Medicine, St Franciscus Gasthuis, Rotterdam, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eelco J.P.","family":"de Koning","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine and Infectious Diseases (J.P.H.v.W. and I.M.H.), University Medical Center, Utrecht, the Netherlands; the Department of Nephrology (E.J.P.d.K. and T.J.R.), University Medical Center, Leiden, the Netherlands; the Department of Vascular Medicine (G.M.D.-T.), Academic Medical Center, Amsterdam, the Netherlands; and the Department of Internal Medicine (M.C.C.), Center for Diabetes and Vascular Medicine, St Franciscus Gasthuis, Rotterdam, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geesje","family":"Dallinga-Thie","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine and Infectious Diseases (J.P.H.v.W. and I.M.H.), University Medical Center, Utrecht, the Netherlands; the Department of Nephrology (E.J.P.d.K. and T.J.R.), University Medical Center, Leiden, the Netherlands; the Department of Vascular Medicine (G.M.D.-T.), Academic Medical Center, Amsterdam, the Netherlands; and the Department of Internal Medicine (M.C.C.), Center for Diabetes and Vascular Medicine, St Franciscus Gasthuis, Rotterdam, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ton J.","family":"Rabelink","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine and Infectious Diseases (J.P.H.v.W. and I.M.H.), University Medical Center, Utrecht, the Netherlands; the Department of Nephrology (E.J.P.d.K. and T.J.R.), University Medical Center, Leiden, the Netherlands; the Department of Vascular Medicine (G.M.D.-T.), Academic Medical Center, Amsterdam, the Netherlands; and the Department of Internal Medicine (M.C.C.), Center for Diabetes and Vascular Medicine, St Franciscus Gasthuis, Rotterdam, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel Castro","family":"Cabezas","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine and Infectious Diseases (J.P.H.v.W. and I.M.H.), University Medical Center, Utrecht, the Netherlands; the Department of Nephrology (E.J.P.d.K. and T.J.R.), University Medical Center, Leiden, the Netherlands; the Department of Vascular Medicine (G.M.D.-T.), Academic Medical Center, Amsterdam, the Netherlands; and the Department of Internal Medicine (M.C.C.), Center for Diabetes and Vascular Medicine, St Franciscus Gasthuis, Rotterdam, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra041811"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200304001-00017"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/pcad.2003.3"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030218"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062744"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-2343"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000152233.80082.9c"},{"key":"e_1_3_4_9_2","first-page":"L46","article-title":"Marked impairment of dietary triglyceride disposal contributes to hypertriglyceridemia in HIV lipodystrophy syndrome","volume":"8","author":"Sekhar RV","year":"2003","unstructured":"Sekhar RV, Iyer D, Gaubatz J, Rehman K, Maldonado M, Pownall HJ, Visnegerwala F, Jahoor F, Balasubramanyam A . 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