{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T01:57:45Z","timestamp":1777341465584,"version":"3.51.4"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:sec>\n            <jats:title>Objective\u2014<\/jats:title>\n            <jats:p>To determine whether serum levels of N-terminal (NT) pro\u2013B-type natriuretic peptide (pro-BNP) are higher in patients with poorly compressible arteries (PCA) than in patients with peripheral artery disease (PAD) and control subjects without PCA or PAD.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              Medial arterial calcification in the lower extremities results in PCA and may be associated with increased arterial stiffness and hemodynamic\/myocardial stress. PCA was defined as having an ankle-brachial index &gt;1.4 or an ankle blood pressure &gt;255 mm Hg, whereas PAD was defined as having an ankle-brachial index \u22640.9. Study participants with PCA (n=100; aged 71\u00b110 years; 70% men) and age- and sex-matched patients with PAD (n=300) were recruited from the noninvasive vascular laboratory. Age- and sex-matched controls (n=300) were identified from a community-based cohort and had no history of PAD. NT pro-BNP levels were approximately 2.5-fold higher in patients with PCA than in patients with PAD and approximately 4-fold higher than in age- and sex-matched controls. In multivariable regression analyses that adjusted for age, sex, smoking, hypertension, history of coronary heart disease\/stroke, systolic blood pressure, and serum creatinine, NT pro-BNP levels remained significantly higher in patients with PCA than in patients with PAD and controls (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion\u2014<\/jats:title>\n            <jats:p>Patients with medial arterial calcification and PCA have higher serum levels of NT pro-BNP than patients with PAD and controls, which is suggestive of an adverse hemodynamic milieu and increased risk for adverse cardiovascular outcomes.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/atvbaha.110.216770","type":"journal-article","created":{"date-parts":[[2010,10,15]],"date-time":"2010-10-15T01:06:25Z","timestamp":1287104785000},"page":"197-202","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["Increased Serum N-Terminal Pro\u2013B-Type Natriuretic Peptide Levels in Patients With Medial Arterial Calcification and Poorly Compressible Leg Arteries"],"prefix":"10.1161","volume":"31","author":[{"given":"Hayan","family":"Jouni","sequence":"first","affiliation":[{"name":"From the Department of Internal Medicine (H.J.), Mayo Clinic, Rochester, Minn; the Gonda Vascular Center (I.J.K.), Mayo Clinic, Rochester, Minn; and the Division of Cardiovascular Diseases (I.J.K. and R.J.R.), Mayo Clinic, Rochester, Minn."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J.","family":"Rodeheffer","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine (H.J.), Mayo Clinic, Rochester, Minn; the Gonda Vascular Center (I.J.K.), Mayo Clinic, Rochester, Minn; and the Division of Cardiovascular Diseases (I.J.K. and R.J.R.), Mayo Clinic, Rochester, Minn."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iftikhar J.","family":"Kullo","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine (H.J.), Mayo Clinic, Rochester, Minn; the Gonda Vascular Center (I.J.K.), Mayo Clinic, Rochester, Minn; and the Division of Cardiovascular Diseases (I.J.K. and R.J.R.), Mayo Clinic, Rochester, Minn."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01926946"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.17.11.1252"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00279127"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2004.11.025"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000112642.63927.54"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.3.6.650"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.19.3.538"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.90476.2008"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2007.00823.x"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.28.6.988"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.4065\/80.8.1029"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/08037050510008931"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2008.108753"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.02.047"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2006.075929"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/000331976701800406"},{"key":"e_1_3_4_18_2","first-page":"686","article-title":"Critical evaluation of stress testing in the diagnosis of peripheral vascular disease","volume":"91","author":"Ouriel K","year":"1982","unstructured":"Ouriel K, McDonnell AE, Metz CE, Zarins CK . Critical evaluation of stress testing in the diagnosis of peripheral vascular disease. Surgery. 1982;91:686\u2013693.","journal-title":"Surgery"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.2.194"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.09.025"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.21.2282"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.88.1.107"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031994"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.13.1609"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/jamia.2010.004366"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.12.032"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi631"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1138\/20080298"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.16.8.978"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2008.01.013"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2006.038"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000131515.03336.f8"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2005.01.012"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2008.01.010"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwi167"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.09.061"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2008.174"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.11.029"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.29.4.999"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.11.010"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI37430"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.109.187526"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.743161"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-1094"}],"container-title":["Arteriosclerosis, Thrombosis, and Vascular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/ATVBAHA.110.216770","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:53:08Z","timestamp":1715554388000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/ATVBAHA.110.216770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["10.1161\/ATVBAHA.110.216770"],"URL":"https:\/\/doi.org\/10.1161\/atvbaha.110.216770","relation":{},"ISSN":["1079-5642","1524-4636"],"issn-type":[{"value":"1079-5642","type":"print"},{"value":"1524-4636","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1]]},"assertion":[{"value":"2010-05-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-09-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-10-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}