{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:18:31Z","timestamp":1790713111851,"version":"4.1.0"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:sec>\n            <jats:title>Objective\u2014<\/jats:title>\n            <jats:p>Thoracic aortic aneurysm is a common complication in patients with bicuspid aortic valve (BAV). Alternatively spliced extra domain A (EDA) of fibronectin (FN) has an essential role in tissue repair. Here we analyze the expression of FN spliceforms in dilated and nondilated ascending aorta of tricuspid aortic valve (TAV) and BAV patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              The mRNA expression was analyzed in the ascending aorta by Affymetrix Exon arrays in patients with TAV (n=40) and BAV (n=69). EDA and extra domain B (EDB) expression was increased in dilated aorta from TAV patients compared with nondilated aorta (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001 and\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05, respectively). In contrast, EDA expression was not increased in dilated aorta from BAV patients (\n              <jats:italic>P<\/jats:italic>\n              =0.25), whereas EDB expression was upregulated (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01). The expression of EDA correlated with maximum aortic diameter in TAV (\u03c1=0.58) but not in BAV (\u03c1=0.15) patients. Protein analyses of EDA-FN showed concordant results. Transforming growth factor-\u03b2 treatment influenced the splicing of FN and enhanced the formation of EDA-containing FN in cultured medial cells from TAV patients but not in cells derived from BAV patients. Gene set enrichment analysis together with multivariate and univariate data analyses of mRNA expression suggested that differences in the transforming growth factor-\u03b2 signaling pathway may explain the impaired EDA inclusion in BAV patients.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion\u2014<\/jats:title>\n            <jats:p>Decreased EDA expression may contribute to increased aneurysm susceptibility of BAV patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/atvbaha.110.218461","type":"journal-article","created":{"date-parts":[[2010,12,10]],"date-time":"2010-12-10T04:49:19Z","timestamp":1291956559000},"page":"691-697","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":51,"title":["Impaired Splicing of Fibronectin Is Associated With Thoracic Aortic Aneurysm Formation in Patients With Bicuspid Aortic Valve"],"prefix":"10.1161","volume":"31","author":[{"given":"Valentina","family":"Paloschi","sequence":"first","affiliation":[{"name":"From the Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden (V.P., S.K., L.F., D.W., A.H., P.E.); INSERM, U698, Paris F-75018, France (D.G., J.-B.M.); Vascular Surgery Section, Department of Molecular Medicine and Surgery (J.R.), Clinical Physiology (J.P., M.J.E., K.C.), Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery (J.L., A.F.-C.), Karolinska Institutet, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanela","family":"Kurtovic","sequence":"additional","affiliation":[{"name":"From the Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden (V.P., S.K., L.F., D.W., A.H., P.E.); INSERM, U698, Paris F-75018, France (D.G., J.-B.M.); Vascular Surgery Section, Department of Molecular Medicine and Surgery (J.R.), Clinical Physiology (J.P., M.J.E., K.C.), Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery (J.L., A.F.-C.), Karolinska Institutet, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lasse","family":"Folkersen","sequence":"additional","affiliation":[{"name":"From the Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden (V.P., S.K., L.F., D.W., A.H., P.E.); INSERM, U698, Paris F-75018, France (D.G., J.-B.M.); Vascular Surgery Section, Department of Molecular Medicine and Surgery (J.R.), Clinical Physiology (J.P., M.J.E., K.C.), Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery (J.L., A.F.-C.), Karolinska Institutet, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Gomez","sequence":"additional","affiliation":[{"name":"From the Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden (V.P., S.K., L.F., D.W., A.H., P.E.); INSERM, U698, Paris F-75018, France (D.G., J.-B.M.); Vascular Surgery Section, Department of Molecular Medicine and Surgery (J.R.), Clinical Physiology (J.P., M.J.E., K.C.), Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery (J.L., A.F.-C.), Karolinska Institutet, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dick","family":"W\u00e5gs\u00e4ter","sequence":"additional","affiliation":[{"name":"From the Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden (V.P., S.K., L.F., D.W., A.H., P.E.); INSERM, U698, Paris F-75018, France (D.G., J.-B.M.); Vascular Surgery Section, Department of Molecular Medicine and Surgery (J.R.), Clinical Physiology (J.P., M.J.E., K.C.), Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery (J.L., A.F.-C.), Karolinska Institutet, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joy","family":"Roy","sequence":"additional","affiliation":[{"name":"From the Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden (V.P., S.K., L.F., D.W., A.H., P.E.); INSERM, U698, Paris F-75018, France (D.G., J.-B.M.); Vascular Surgery Section, Department of Molecular Medicine and Surgery (J.R.), Clinical Physiology (J.P., M.J.E., K.C.), Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery (J.L., A.F.-C.), Karolinska Institutet, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Petrini","sequence":"additional","affiliation":[{"name":"From the Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden (V.P., S.K., L.F., D.W., A.H., P.E.); INSERM, U698, Paris F-75018, France (D.G., J.-B.M.); Vascular Surgery Section, Department of Molecular Medicine and Surgery (J.R.), Clinical Physiology (J.P., M.J.E., K.C.), Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery (J.L., A.F.-C.), Karolinska Institutet, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria J.","family":"Eriksson","sequence":"additional","affiliation":[{"name":"From the Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden (V.P., S.K., L.F., D.W., A.H., P.E.); INSERM, U698, Paris F-75018, France (D.G., J.-B.M.); Vascular Surgery Section, Department of Molecular Medicine and Surgery (J.R.), Clinical Physiology (J.P., M.J.E., K.C.), Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery (J.L., A.F.-C.), Karolinska Institutet, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Caidahl","sequence":"additional","affiliation":[{"name":"From the Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden (V.P., S.K., L.F., D.W., A.H., P.E.); INSERM, U698, Paris F-75018, France (D.G., J.-B.M.); Vascular Surgery Section, Department of Molecular Medicine and Surgery (J.R.), Clinical Physiology (J.P., M.J.E., K.C.), Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery (J.L., A.F.-C.), Karolinska Institutet, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Hamsten","sequence":"additional","affiliation":[{"name":"From the Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden (V.P., S.K., L.F., D.W., A.H., P.E.); INSERM, U698, Paris F-75018, France (D.G., J.-B.M.); Vascular Surgery Section, Department of Molecular Medicine and Surgery (J.R.), Clinical Physiology (J.P., M.J.E., K.C.), Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery (J.L., A.F.-C.), Karolinska Institutet, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Liska","sequence":"additional","affiliation":[{"name":"From the Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden (V.P., S.K., L.F., D.W., A.H., P.E.); INSERM, U698, Paris F-75018, France (D.G., J.-B.M.); Vascular Surgery Section, Department of Molecular Medicine and Surgery (J.R.), Clinical Physiology (J.P., M.J.E., K.C.), Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery (J.L., A.F.-C.), Karolinska Institutet, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Baptiste","family":"Michel","sequence":"additional","affiliation":[{"name":"From the Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden (V.P., S.K., L.F., D.W., A.H., P.E.); INSERM, U698, Paris F-75018, France (D.G., J.-B.M.); Vascular Surgery Section, Department of Molecular Medicine and Surgery (J.R.), Clinical Physiology (J.P., M.J.E., K.C.), Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery (J.L., A.F.-C.), Karolinska Institutet, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Franco-Cereceda","sequence":"additional","affiliation":[{"name":"From the Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden (V.P., S.K., L.F., D.W., A.H., P.E.); INSERM, U698, Paris F-75018, France (D.G., J.-B.M.); Vascular Surgery Section, Department of Molecular Medicine and Surgery (J.R.), Clinical Physiology (J.P., M.J.E., K.C.), Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery (J.L., A.F.-C.), Karolinska Institutet, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Eriksson","sequence":"additional","affiliation":[{"name":"From the Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden (V.P., S.K., L.F., D.W., A.H., P.E.); INSERM, U698, Paris F-75018, France (D.G., J.-B.M.); Vascular Surgery Section, Department of Molecular Medicine and Surgery (J.R.), Clinical Physiology (J.P., M.J.E., K.C.), Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery (J.L., A.F.-C.), Karolinska Institutet, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2008.08.002"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.2516"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.2459\/01.JCM.0000199777.85343.ec"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.atv.0000055441.28842.0a"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000087449.03964.fb"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.09091437"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2007.09.009"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(83)90175-7"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2007.03.014"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200708-1291OC"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200212079"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-009-9136-6"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.05.007"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(90)80664-5"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000151766"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq224"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2007.07.005"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.121.6.1845"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.2388"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.106.2.375"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1996.0070"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(87)90206-5"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.119.4.1079"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.109.1.357"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.142.3.873"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1006\/excr.2000.4869"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.0000038996.97287.9a"}],"container-title":["Arteriosclerosis, Thrombosis, and Vascular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/ATVBAHA.110.218461","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T23:04:14Z","timestamp":1715555054000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/ATVBAHA.110.218461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["10.1161\/ATVBAHA.110.218461"],"URL":"https:\/\/doi.org\/10.1161\/atvbaha.110.218461","relation":{},"ISSN":["1079-5642","1524-4636"],"issn-type":[{"value":"1079-5642","type":"print"},{"value":"1524-4636","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3]]},"assertion":[{"value":"2010-06-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-11-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-12-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}