{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T11:37:14Z","timestamp":1789213034028,"version":"build-2803163510"},"reference-count":46,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:sec>\n            <jats:title>Objective\u2014<\/jats:title>\n            <jats:p>\n              The purpose of this study was to evaluate whether exenatide administration can prevent impairment in endothelium-dependent vasodilatation induced by ischemia-reperfusion (IR) injury and whether this effect is mediated by K\n              <jats:sub>ATP<\/jats:sub>\n              channel opening.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              In a double-blind, placebo-controlled, crossover design, 20 volunteers were randomly assigned to 2 groups: subcutaneous exenatide (10 \u03bcg) or placebo administration. At 30 minutes after the study drug administration, endothelium-dependent flow-mediated dilatation (FMD) of the radial artery was measured before and after IR (15 minutes of ischemia at the level of the brachial artery followed by 15 minutes of reperfusion) injury. Seven days later, both groups were crossed over and received the other treatment (ie, placebo or exenatide) and underwent the same protocol. Pre-IR radial artery diameter, FMD, and baseline radial artery diameter after IR injury were similar between 2 groups (\n              <jats:italic>P<\/jats:italic>\n              =no significant difference). After placebo administration, IR significantly blunted FMD (before IR: 12.0\u00b16.23%; after IR: 4.6\u00b13.57%,\n              <jats:italic>P<\/jats:italic>\n              =0.02). Exenatide prevented this impairment (FMD before IR: 15.0\u00b17.14%; FMD after IR: 15.0\u00b15.96%,\n              <jats:italic>P<\/jats:italic>\n              =no significant difference;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001 compared with placebo). In a separate protocol, this protective effect was completely abolished by pretreatment with glibenclamide (glyburide, 5 mg), a blocker of K\n              <jats:sub>ATP<\/jats:sub>\n              channels (n=7; FMD before IR: 12.0\u00b12.2%; after IR: 3.2\u00b12.1%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion\u2014<\/jats:title>\n            <jats:p>\n              The present study demonstrates that subcutaneous exenatide protects IR-induced endothelial dysfunction through opening of K\n              <jats:sub>ATP<\/jats:sub>\n              channels in human IR injury model.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/atvbaha.110.222653","type":"journal-article","created":{"date-parts":[[2011,12,9]],"date-time":"2011-12-09T07:28:16Z","timestamp":1323415696000},"page":"474-480","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":54,"title":["Preventive Effects of Exenatide on Endothelial Dysfunction Induced by Ischemia-Reperfusion Injury via K\n            <sub>ATP<\/sub>\n            Channels"],"prefix":"10.1161","volume":"32","author":[{"given":"Sang Jin","family":"Ha","sequence":"first","affiliation":[{"name":"From the Division of Cardiology, Department of Internal Medicine, Kyung Hee University Hospital, Seoul, Republic of Korea (S.J.H., W.K., J.S.W., J.B.K., S.J.K., W.-S.K., M.K.K., K.S.K.); Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan (X.W.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weon","family":"Kim","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Internal Medicine, Kyung Hee University Hospital, Seoul, Republic of Korea (S.J.H., W.K., J.S.W., J.B.K., S.J.K., W.-S.K., M.K.K., K.S.K.); Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan (X.W.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Shin","family":"Woo","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Internal Medicine, Kyung Hee University Hospital, Seoul, Republic of Korea (S.J.H., W.K., J.S.W., J.B.K., S.J.K., W.-S.K., M.K.K., K.S.K.); Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan (X.W.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Bae","family":"Kim","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Internal Medicine, Kyung Hee University Hospital, Seoul, Republic of Korea (S.J.H., W.K., J.S.W., J.B.K., S.J.K., W.-S.K., M.K.K., K.S.K.); Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan (X.W.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Joong","family":"Kim","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Internal Medicine, Kyung Hee University Hospital, Seoul, Republic of Korea (S.J.H., W.K., J.S.W., J.B.K., S.J.K., W.-S.K., M.K.K., K.S.K.); Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan (X.W.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo-Shik","family":"Kim","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Internal Medicine, Kyung Hee University Hospital, Seoul, Republic of Korea (S.J.H., W.K., J.S.W., J.B.K., S.J.K., W.-S.K., M.K.K., K.S.K.); Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan (X.W.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myeong Kon","family":"Kim","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Internal Medicine, Kyung Hee University Hospital, Seoul, Republic of Korea (S.J.H., W.K., J.S.W., J.B.K., S.J.K., W.-S.K., M.K.K., K.S.K.); 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