{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:28:13Z","timestamp":1791300493703,"version":"4.1.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:sec>\n            <jats:title>Objective\u2014<\/jats:title>\n            <jats:p>Interleukin 17A (IL17A) is involved in many inflammatory processes, but its role in atherosclerosis remains controversial. We examined the role of IL17A in mouse and human atherosclerosis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              Atherosclerosis was induced in apolipoprotein E (ApoE)\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              and IL17A\/ApoE\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              mice using high-fat feeding, angiotensin II infusion, or partial carotid ligation. In ApoE\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              mice, 3 months of high-fat diet induced interferon-\u03b3 production by splenic lymphocytes, and this was abrogated in IL17A\/ApoE\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              mice. IL17A\/ApoE\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              mice had reduced aortic superoxide production, increased aortic nitric oxide levels, decreased aortic leukocyte and dendritic cell infiltration, and reduced weight gain after a high-fat diet compared with ApoE\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              mice. Despite these favorable effects, IL17A deficiency did not affect aortic plaque burden after a high-fat diet or angiotensin II infusion. In a partial carotid ligation model, IL17A deficiency did not affect percentage of stenosis but reduced outward remodeling. In this model, neutralization of the related isoform, IL17F, in IL17A\/ApoE\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              mice did not alter atherosclerosis. Finally, there was no correlation between IL17A levels and carotid intima-media thickness in humans.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion\u2014<\/jats:title>\n            <jats:p>IL17 contributes to vascular and systemic inflammation in experimental atherosclerosis but does not alter plaque burden. The changes in plaque composition caused by IL17 might modulate plaque stability.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/atvbaha.111.227629","type":"journal-article","created":{"date-parts":[[2011,4,8]],"date-time":"2011-04-08T04:26:35Z","timestamp":1302236795000},"page":"1565-1572","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":199,"title":["Role of Interleukin 17 in Inflammation, Atherosclerosis, and Vascular Function in Apolipoprotein E\u2013Deficient Mice"],"prefix":"10.1161","volume":"31","author":[{"given":"Meena S.","family":"Madhur","sequence":"first","affiliation":[{"name":"From the Division of Cardiology, Emory University, Atlanta, GA (M.S.M., S.A.F., L.L., A.V., H.E.L., Y.B., A.R., A.A.Q.); Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan (Y.I.); Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Vanderbilt University, Nashville, TN (W.C., D.G.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel A.","family":"Funt","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Emory University, Atlanta, GA (M.S.M., S.A.F., L.L., A.V., H.E.L., Y.B., A.R., A.A.Q.); Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan (Y.I.); Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Vanderbilt University, Nashville, TN (W.C., D.G.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Emory University, Atlanta, GA (M.S.M., S.A.F., L.L., A.V., H.E.L., Y.B., A.R., A.A.Q.); Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan (Y.I.); Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Vanderbilt University, Nashville, TN (W.C., D.G.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antony","family":"Vinh","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Emory University, Atlanta, GA (M.S.M., S.A.F., L.L., A.V., H.E.L., Y.B., A.R., A.A.Q.); Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan (Y.I.); Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Vanderbilt University, Nashville, TN (W.C., D.G.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Emory University, Atlanta, GA (M.S.M., S.A.F., L.L., A.V., H.E.L., Y.B., A.R., A.A.Q.); Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan (Y.I.); Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Vanderbilt University, Nashville, TN (W.C., D.G.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinrich E.","family":"Lob","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Emory University, Atlanta, GA (M.S.M., S.A.F., L.L., A.V., H.E.L., Y.B., A.R., A.A.Q.); Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan (Y.I.); Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Vanderbilt University, Nashville, TN (W.C., D.G.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichiro","family":"Iwakura","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Emory University, Atlanta, GA (M.S.M., S.A.F., L.L., A.V., H.E.L., Y.B., A.R., A.A.Q.); Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan (Y.I.); Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Vanderbilt University, Nashville, TN (W.C., D.G.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yelena","family":"Blinder","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Emory University, Atlanta, GA (M.S.M., S.A.F., L.L., A.V., H.E.L., Y.B., A.R., A.A.Q.); Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan (Y.I.); Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Vanderbilt University, Nashville, TN (W.C., D.G.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayaz","family":"Rahman","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Emory University, Atlanta, GA (M.S.M., S.A.F., L.L., A.V., H.E.L., Y.B., A.R., A.A.Q.); Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan (Y.I.); Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Vanderbilt University, Nashville, TN (W.C., D.G.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arshed A.","family":"Quyyumi","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Emory University, Atlanta, GA (M.S.M., S.A.F., L.L., A.V., H.E.L., Y.B., A.R., A.A.Q.); Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan (Y.I.); Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Vanderbilt University, Nashville, TN (W.C., D.G.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Harrison","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Emory University, Atlanta, GA (M.S.M., S.A.F., L.L., A.V., H.E.L., Y.B., A.R., A.A.Q.); Center for Experimental Medicine and Systems 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