{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:03:32Z","timestamp":1791216212901,"version":"4.1.0"},"reference-count":46,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:sec>\n            <jats:title>Objective\u2014<\/jats:title>\n            <jats:p>Obese adipose tissue shows hallmarks of chronic inflammation, which promotes the development of metabolic disorders. The mechanisms by which immune cells interact with each other or with metabolism-associated cell types, and the players involved, are still unclear. The CD40-CD40L costimulatory dyad plays a pivotal role in immune responses and in diseases such as atherosclerosis and may therefore be a mediator of obesity. Here we investigated whether CD40L is involved in adipose tissue inflammation and its associated metabolic changes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              To assess a putative role of CD40L in obesity in vivo, we evaluated metabolic and inflammatory consequences of 18 weeks of high-fat feeding in\n              <jats:italic>CD40L<\/jats:italic>\n              <jats:sup>+\/+<\/jats:sup>\n              and\n              <jats:italic>CD40L<\/jats:italic>\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              mice. In addition, C57Bl6 mice were injected with neutralizing anti-CD40L (\u03b1CD40L) antibody for 12 weeks while being fed a high-fat diet. Genetic deficiency of CD40L attenuated the development of diet-induced obesity, hepatic steatosis, and increased systemic insulin sensitivity. In adipose tissue, it impaired obesity-induced immune cell infiltration and the associated deterioration of glucose and lipid metabolism. Accordingly, \u03b1CD40L treatment improved systemic insulin sensitivity, glucose tolerance, and CD4\n              <jats:sup>+<\/jats:sup>\n              T-cell infiltration in adipose tissue with limited effects on adipose tissue weight.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion\u2014<\/jats:title>\n            <jats:p>CD40L plays a crucial role in the development of obesity-induced inflammation and metabolic complications.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/atvbaha.111.231357","type":"journal-article","created":{"date-parts":[[2011,8,5]],"date-time":"2011-08-05T04:23:23Z","timestamp":1312518203000},"page":"2251-2260","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":86,"title":["CD40L Deficiency Ameliorates Adipose Tissue Inflammation and Metabolic Manifestations of Obesity in Mice"],"prefix":"10.1161","volume":"31","author":[{"given":"Marjorie","family":"Poggi","sequence":"first","affiliation":[{"name":"From the Department of Pathology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands (M.P., D.E., A.C., L.B., E.W., A.D., J.C., N.G., E.L.); Bioceros BV, Utrecht, the Netherlands (L.B.); Institute for Cardiovascular Prevention, Ludwig-Maximilians University Munich, Munich, Germany (C.W., N.G., E.L.) and Munich Heart Alliance, Munich, Germany (C.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Engel","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands (M.P., D.E., A.C., L.B., E.W., A.D., J.C., N.G., E.L.); Bioceros BV, Utrecht, the Netherlands (L.B.); Institute for Cardiovascular Prevention, Ludwig-Maximilians University Munich, Munich, Germany (C.W., N.G., E.L.) and Munich Heart Alliance, Munich, Germany (C.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anette","family":"Christ","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands (M.P., D.E., A.C., L.B., E.W., A.D., J.C., N.G., E.L.); Bioceros BV, Utrecht, the Netherlands (L.B.); Institute for Cardiovascular Prevention, Ludwig-Maximilians University Munich, Munich, Germany (C.W., N.G., E.L.) and Munich Heart Alliance, Munich, Germany (C.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Beckers","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands (M.P., D.E., A.C., L.B., E.W., A.D., J.C., N.G., E.L.); Bioceros BV, Utrecht, the Netherlands (L.B.); Institute for Cardiovascular Prevention, Ludwig-Maximilians University Munich, Munich, Germany (C.W., N.G., E.L.) and Munich Heart Alliance, Munich, Germany (C.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwin","family":"Wijnands","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands (M.P., D.E., A.C., L.B., E.W., A.D., J.C., N.G., E.L.); Bioceros BV, Utrecht, the Netherlands (L.B.); Institute for Cardiovascular Prevention, Ludwig-Maximilians University Munich, Munich, Germany (C.W., N.G., E.L.) and Munich Heart Alliance, Munich, Germany (C.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Boon","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands (M.P., D.E., A.C., L.B., E.W., A.D., J.C., N.G., E.L.); Bioceros BV, Utrecht, the Netherlands (L.B.); Institute for Cardiovascular Prevention, Ludwig-Maximilians University Munich, Munich, Germany (C.W., N.G., E.L.) and Munich Heart Alliance, Munich, Germany (C.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Driessen","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands (M.P., D.E., A.C., L.B., E.W., A.D., J.C., N.G., E.L.); Bioceros BV, Utrecht, the Netherlands (L.B.); Institute for Cardiovascular Prevention, Ludwig-Maximilians University Munich, Munich, Germany (C.W., N.G., E.L.) and Munich Heart Alliance, Munich, Germany (C.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Cleutjens","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands (M.P., D.E., A.C., L.B., E.W., A.D., J.C., N.G., E.L.); Bioceros BV, Utrecht, the Netherlands (L.B.); Institute for Cardiovascular Prevention, Ludwig-Maximilians University Munich, Munich, Germany (C.W., N.G., E.L.) and Munich Heart Alliance, Munich, Germany (C.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Weber","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands (M.P., D.E., A.C., L.B., E.W., A.D., J.C., N.G., E.L.); Bioceros BV, Utrecht, the Netherlands (L.B.); Institute for Cardiovascular Prevention, Ludwig-Maximilians University Munich, Munich, Germany (C.W., N.G., E.L.) and Munich Heart Alliance, Munich, Germany (C.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Gerdes","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands (M.P., D.E., A.C., L.B., E.W., A.D., J.C., N.G., E.L.); Bioceros BV, Utrecht, the Netherlands (L.B.); Institute for Cardiovascular Prevention, Ludwig-Maximilians University Munich, Munich, Germany (C.W., N.G., E.L.) and Munich Heart Alliance, Munich, Germany (C.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Lutgens","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands (M.P., D.E., A.C., L.B., E.W., A.D., J.C., N.G., E.L.); Bioceros BV, Utrecht, the Netherlands (L.B.); Institute for Cardiovascular Prevention, Ludwig-Maximilians University Munich, Munich, Germany (C.W., N.G., E.L.) and Munich Heart Alliance, Munich, Germany (C.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05485"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29069"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2010.1"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.110.218867"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200838893"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1964"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2001"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2002"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.8.2277"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24335"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1994"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00008.2006"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1937"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0809-846"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2009.05.012"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/28204"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/15271"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.13.7464"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2009.06.004"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-009-1267-1"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH09-07-0463"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.14.1781"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000129773.70647.94"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000025419.95769.f0"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-006-0222-7"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000069272.06194.91"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.46.5.860"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20091293"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20701"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i18.2223"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.3109\/10409231003667500"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0b013e3283393867"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1004-971"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2921"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1262-3636(08)74599-3"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.2337\/db06-0133"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23935"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2010.02468.x"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.90669.2008"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05026"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2008.10.007"},{"key":"e_1_3_3_43_2","first-page":"568343","article-title":"Role of leptin in the activation of immune cells","author":"Fernandez-Riejos P","year":"2010","unstructured":"Fernandez-Riejos P, Najib S, Santos-Alvarez J, Martin-Romero C, Perez-Perez A, Gonzalez-Yanes C, Sanchez-Margalet V. 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