{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T04:51:21Z","timestamp":1780721481743,"version":"3.54.1"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:sec>\n            <jats:title>Objective\u2014<\/jats:title>\n            <jats:p>The development of a murine model of spontaneous atherosclerotic plaque rupture with luminal thrombus.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>Combined partial ligation of the left renal artery and left common carotid artery in 8-week-old apolipoprotein E\u2013deficient mice induced endogenous renovascular hypertension and local low oscillatory shear stress in the left common carotid artery. After 8 weeks, a fresh left common carotid artery lumen thrombus associated with severe plaque burden was found in 50% (10\/20) of the mice. Histological analyses indicated that all left common carotid artery lesions had vulnerable features, and 50% (5\/10) of the mice showed plaque rupture with a lumen thrombus. Multiple layers with layering discontinuity and intraplaque hemorrhages were found in 80% (8\/10) of the mice. Further experiments showed that both increased blood pressure, and angiotensin-II contributed to plaque progression and vulnerability. Decreased intimal collagen associated with increased collagenase activity and matrix metalloproteinase expression also resulted in plaque disruption.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion\u2014<\/jats:title>\n            <jats:p>We demonstrate a murine model of spontaneous plaque rupture with a high incidence of luminal thrombus. The model not only nicely recapitulates the pathophysiological processes of human plaque rupture but it is also simple, fast, and highly efficient to generate.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/atvbaha.111.236158","type":"journal-article","created":{"date-parts":[[2012,8,17]],"date-time":"2012-08-17T05:41:03Z","timestamp":1345182063000},"page":"2372-2379","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":48,"title":["Endogenous Renovascular Hypertension Combined With Low Shear Stress Induces Plaque Rupture in Apolipoprotein E\u2013Deficient Mice"],"prefix":"10.1161","volume":"32","author":[{"given":"Shu-xuan","family":"Jin","sequence":"first","affiliation":[{"name":"From the Department of Cardiology, Renji Hospital (S.J., L.S., P.N., W.Y., L.H., D.L., B.H.), and Department of Laboratory Animal Science (X.C.), Shanghai Jiaotong University School of Medicine, Shanghai, China; and Cancer Center (X.Z.), Sandford-Burnham Medical Research Institute, La Jolla, CA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-hong","family":"Shen","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Renji Hospital (S.J., L.S., P.N., W.Y., L.H., D.L., B.H.), and Department of Laboratory Animal Science (X.C.), Shanghai Jiaotong University School of Medicine, Shanghai, China; and Cancer Center (X.Z.), Sandford-Burnham Medical Research Institute, La Jolla, CA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Nie","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Renji Hospital (S.J., L.S., P.N., W.Y., L.H., D.L., B.H.), and Department of Laboratory Animal Science (X.C.), Shanghai Jiaotong University School of Medicine, Shanghai, China; and Cancer Center (X.Z.), Sandford-Burnham Medical Research Institute, La Jolla, CA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yuan","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Renji Hospital (S.J., L.S., P.N., W.Y., L.H., D.L., B.H.), and Department of Laboratory Animal Science (X.C.), Shanghai Jiaotong University School of Medicine, Shanghai, China; and Cancer Center (X.Z.), Sandford-Burnham Medical Research Institute, La Jolla, CA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu-hua","family":"Hu","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Renji Hospital (S.J., L.S., P.N., W.Y., L.H., D.L., B.H.), and Department of Laboratory Animal Science (X.C.), Shanghai Jiaotong University School of Medicine, Shanghai, China; and Cancer Center (X.Z.), Sandford-Burnham Medical Research Institute, La Jolla, CA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan-dan","family":"Li","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Renji Hospital (S.J., L.S., P.N., W.Y., L.H., D.L., B.H.), and Department of Laboratory Animal Science (X.C.), Shanghai Jiaotong University School of Medicine, Shanghai, China; and Cancer Center (X.Z.), Sandford-Burnham Medical Research Institute, La Jolla, CA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-jin","family":"Chen","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Renji Hospital (S.J., L.S., P.N., W.Y., L.H., D.L., B.H.), and Department of Laboratory Animal Science (X.C.), Shanghai Jiaotong University School of Medicine, Shanghai, China; and Cancer Center (X.Z.), Sandford-Burnham Medical Research Institute, La Jolla, CA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-kun","family":"Zhang","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Renji Hospital (S.J., L.S., P.N., W.Y., L.H., D.L., B.H.), and Department of Laboratory Animal Science (X.C.), Shanghai Jiaotong University School of Medicine, Shanghai, China; and Cancer Center (X.Z.), Sandford-Burnham Medical Research Institute, La Jolla, CA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"He","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Renji Hospital (S.J., L.S., P.N., W.Y., L.H., D.L., B.H.), and Department of Laboratory Animal Science (X.C.), Shanghai Jiaotong University School of Medicine, Shanghai, China; and Cancer Center (X.Z.), Sandford-Burnham Medical Research Institute, La Jolla, CA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"6","key":"e_1_3_3_2_2","first-page":"III30","article-title":"Why do plaques rupture?","volume":"86","author":"Falk E","year":"1992","unstructured":"Falk E. 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