{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T21:27:54Z","timestamp":1791149274619,"version":"4.1.0"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:sec>\n            <jats:title>Objective\u2014<\/jats:title>\n            <jats:p>\n              <jats:italic>Gpihbp1<\/jats:italic>\n              -deficient (\n              <jats:italic>Gpihbp1<\/jats:italic>\n              \u2212\/\u2212) mice lack the ability to transport lipoprotein lipase to the capillary lumen, resulting in mislocalization of lipoprotein lipase within tissues, defective lipolysis of triglyceride-rich lipoproteins, and chylomicronemia. We asked whether GPIHBP1 deficiency and mislocalization of catalytically active lipoprotein lipase would alter the composition of triglycerides in adipose tissue or perturb the expression of lipid biosynthetic genes. We also asked whether perturbations in adipose tissue composition and gene expression, if they occur, would be accompanied by reciprocal metabolic changes in the liver.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              The chylomicronemia in\n              <jats:italic>Gpihbp1<\/jats:italic>\n              \u2212\/\u2212 mice was associated with reduced levels of essential fatty acids in adipose tissue triglycerides and increased expression of lipid biosynthetic genes. The liver exhibited the opposite changes: increased levels of essential fatty acids in triglycerides and reduced expression of lipid biosynthetic genes.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion\u2014<\/jats:title>\n            <jats:p>\n              Defective lipolysis in\n              <jats:italic>Gpihbp1<\/jats:italic>\n              \u2212\/\u2212 mice causes reciprocal metabolic perturbations in adipose tissue and liver. In adipose tissue, the essential fatty acid content of triglycerides is reduced and lipid biosynthetic gene expression is increased, whereas the opposite changes occur in the liver.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/atvbaha.111.241406","type":"journal-article","created":{"date-parts":[[2011,12,16]],"date-time":"2011-12-16T06:54:49Z","timestamp":1324018489000},"page":"230-235","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":32,"title":["Reciprocal Metabolic Perturbations in the Adipose Tissue and Liver of GPIHBP1-Deficient Mice"],"prefix":"10.1161","volume":"32","author":[{"given":"Michael M.","family":"Weinstein","sequence":"first","affiliation":[{"name":"From the Departments of Medicine (M.M.W., C.N.G., B.S.J.D., Y.T., R.H.B., A.P.B., L.G.F., S.G.Y.), Human Genetics (M.M.W., K.R., S.G.Y.), and Pathology (P.T.), University of California, Los Angeles, CA; Tethys Bioscience, Emeryville, CA (S.M.W., R.D.); Howard Hughes Medical Institute (P.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher N.","family":"Goulbourne","sequence":"additional","affiliation":[{"name":"From the Departments of Medicine (M.M.W., C.N.G., B.S.J.D., Y.T., R.H.B., A.P.B., L.G.F., S.G.Y.), Human Genetics (M.M.W., K.R., S.G.Y.), and Pathology (P.T.), University of California, Los Angeles, CA; Tethys Bioscience, Emeryville, CA (S.M.W., R.D.); Howard Hughes Medical Institute (P.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon S.J.","family":"Davies","sequence":"additional","affiliation":[{"name":"From the Departments of Medicine (M.M.W., C.N.G., B.S.J.D., Y.T., R.H.B., A.P.B., L.G.F., S.G.Y.), Human Genetics (M.M.W., K.R., S.G.Y.), and Pathology (P.T.), University of California, Los Angeles, CA; Tethys Bioscience, Emeryville, CA (S.M.W., R.D.); Howard Hughes Medical Institute (P.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Tu","sequence":"additional","affiliation":[{"name":"From the Departments of Medicine (M.M.W., C.N.G., B.S.J.D., Y.T., R.H.B., A.P.B., L.G.F., S.G.Y.), Human Genetics (M.M.W., K.R., S.G.Y.), and Pathology (P.T.), University of California, Los Angeles, CA; Tethys Bioscience, Emeryville, CA (S.M.W., R.D.); Howard Hughes Medical Institute (P.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"II","given":"Richard H.","family":"Barnes","sequence":"additional","affiliation":[{"name":"From the Departments of Medicine (M.M.W., C.N.G., B.S.J.D., Y.T., R.H.B., A.P.B., L.G.F., S.G.Y.), Human Genetics (M.M.W., K.R., S.G.Y.), and Pathology (P.T.), University of California, Los Angeles, CA; Tethys Bioscience, Emeryville, CA (S.M.W., R.D.); Howard Hughes Medical Institute (P.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M.","family":"Watkins","sequence":"additional","affiliation":[{"name":"From the Departments of Medicine (M.M.W., C.N.G., B.S.J.D., Y.T., R.H.B., A.P.B., L.G.F., S.G.Y.), Human Genetics (M.M.W., K.R., S.G.Y.), and Pathology (P.T.), University of California, Los Angeles, CA; Tethys Bioscience, Emeryville, CA (S.M.W., R.D.); Howard Hughes Medical Institute (P.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Davis","sequence":"additional","affiliation":[{"name":"From the Departments of Medicine (M.M.W., C.N.G., B.S.J.D., Y.T., R.H.B., A.P.B., L.G.F., S.G.Y.), Human Genetics (M.M.W., K.R., S.G.Y.), and Pathology (P.T.), University of California, Los Angeles, CA; Tethys Bioscience, Emeryville, CA (S.M.W., R.D.); Howard Hughes Medical Institute (P.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Reue","sequence":"additional","affiliation":[{"name":"From the Departments of Medicine (M.M.W., C.N.G., B.S.J.D., Y.T., R.H.B., A.P.B., L.G.F., S.G.Y.), Human Genetics (M.M.W., K.R., S.G.Y.), and Pathology (P.T.), University of California, Los Angeles, CA; Tethys Bioscience, Emeryville, CA (S.M.W., R.D.); Howard Hughes Medical Institute (P.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Tontonoz","sequence":"additional","affiliation":[{"name":"From the Departments of Medicine (M.M.W., C.N.G., B.S.J.D., Y.T., R.H.B., A.P.B., L.G.F., S.G.Y.), Human Genetics (M.M.W., K.R., S.G.Y.), and Pathology (P.T.), University of California, Los Angeles, CA; Tethys Bioscience, Emeryville, CA (S.M.W., R.D.); Howard Hughes Medical Institute (P.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne P.","family":"Beigneux","sequence":"additional","affiliation":[{"name":"From the Departments of Medicine (M.M.W., C.N.G., B.S.J.D., Y.T., R.H.B., A.P.B., L.G.F., S.G.Y.), Human Genetics (M.M.W., K.R., S.G.Y.), and Pathology (P.T.), University of California, Los Angeles, CA; Tethys Bioscience, Emeryville, CA (S.M.W., R.D.); Howard Hughes Medical Institute (P.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loren G.","family":"Fong","sequence":"additional","affiliation":[{"name":"From the Departments of Medicine (M.M.W., C.N.G., B.S.J.D., Y.T., R.H.B., A.P.B., L.G.F., S.G.Y.), Human Genetics (M.M.W., K.R., S.G.Y.), and Pathology (P.T.), University of California, Los Angeles, CA; Tethys Bioscience, Emeryville, CA (S.M.W., R.D.); Howard Hughes Medical Institute (P.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen G.","family":"Young","sequence":"additional","affiliation":[{"name":"From the Departments of Medicine (M.M.W., C.N.G., B.S.J.D., Y.T., R.H.B., A.P.B., L.G.F., S.G.Y.), Human Genetics (M.M.W., K.R., S.G.Y.), and Pathology (P.T.), University of California, Los Angeles, CA; Tethys Bioscience, Emeryville, CA (S.M.W., R.D.); Howard Hughes Medical Institute (P.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2010.04.016"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M806067200"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.02.002"},{"key":"e_1_3_3_5_2","first-page":"2789","volume-title":"The Metabolic and Molecular Bases of Inherited Disease","author":"Brunzell JD","year":"2001","unstructured":"Brunzell JD, Deeb SS. Familial lipoprotein lipase deficiency, apo C-II deficiency, and hepatic lipase deficiency. In: , Scriver CR, Beaudet AL, Sly WS, Valle D, Childs B, Kinzler KW, Vogelstein B, eds. The Metabolic and Molecular Bases of Inherited Disease. New York: McGraw-Hill; 2001: p. 2789."},{"key":"e_1_3_3_6_2","first-page":"273","article-title":"Adipose tissue fatty acid composition in humans with lipoprotein lipase deficiency","volume":"49","author":"Ullrich NF","year":"2001","unstructured":"Ullrich NF, Purnell JQ, Brunzell JD. Adipose tissue fatty acid composition in humans with lipoprotein lipase deficiency. J Investig Med. 2001;49:273\u2013275.","journal-title":"J Investig Med"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.12.2980"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.19.10261"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.27.17182"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M300293-JLR200"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI16751"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)64849-5"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.110.214403"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.171041"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200515972"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.108.178756"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511X-6-23"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115206"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00093.2003"}],"container-title":["Arteriosclerosis, Thrombosis, and Vascular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/ATVBAHA.111.241406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:57:03Z","timestamp":1715554623000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/ATVBAHA.111.241406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["10.1161\/ATVBAHA.111.241406"],"URL":"https:\/\/doi.org\/10.1161\/atvbaha.111.241406","relation":{},"ISSN":["1079-5642","1524-4636"],"issn-type":[{"value":"1079-5642","type":"print"},{"value":"1524-4636","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2]]},"assertion":[{"value":"2011-11-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-11-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-12-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}