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Once VLDLs are synthesized in the lumen of the endoplasmic reticulum, they are transported to the Golgi. The transport of nascent VLDLs from the endoplasmic reticulum to Golgi is a complex multistep process, which is mediated by a specialized transport vesicle, the VLDL transport vesicle. The VLDL transport vesicle delivers VLDLs to the\n            <jats:italic>cis<\/jats:italic>\n            -Golgi lumen where nascent VLDLs undergo a number of essential modifications. The mature VLDL particles are then transported to the plasma membrane and secreted in the circulatory system. Understanding of molecular mechanisms and identification of factors regulating the complex intracellular VLDL trafficking will provide insight into the pathophysiology of various metabolic disorders associated with abnormal VLDL secretion and identify potential new therapeutic targets.\n          <\/jats:p>","DOI":"10.1161\/atvbaha.111.241471","type":"journal-article","created":{"date-parts":[[2012,4,18]],"date-time":"2012-04-18T20:46:16Z","timestamp":1334781976000},"page":"1079-1086","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":255,"title":["Intracellular Trafficking and Secretion of VLDL"],"prefix":"10.1161","volume":"32","author":[{"given":"Samata","family":"Tiwari","sequence":"first","affiliation":[{"name":"From the Burnett School of Biomedical Sciences (S.T., S.A.S.), College of Medicine, University of Central Florida, 6900 Lake Nona Boulevard, Orlando, FL."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shadab A.","family":"Siddiqi","sequence":"additional","affiliation":[{"name":"From the Burnett School of Biomedical Sciences (S.T., S.A.S.), College of Medicine, University of Central Florida, 6900 Lake Nona Boulevard, Orlando, FL."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000035280.64322.31"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00041433-199410000-00006"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M800248-JLR200"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R100068200"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(94)90249-6"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1050-1738(01)00071-8"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008885200"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M107460200"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.69.2.241"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2005.01556.x"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R800090-JLR200"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/1743-7075-7-35"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2011.04.007"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2006.01.009"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.14.4597"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)39221-X"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3659919"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.5.2465"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00123.2007"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021909-135801"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.2.500"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)30267-4"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi011757l"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/346382a0"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90202-N"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)39874-6"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/129.2.463S"},{"key":"e_1_3_3_29_2","first-page":"456S","article-title":"Apolipoprotein B in the rough endoplasmic reticulum: translation, translocation and the initiation of lipoprotein assembly.","volume":"129","author":"Shelness GS","year":"1999","unstructured":"Shelness GS, Ingram MF, Huang XF, DeLozier JA. 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