{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:02:04Z","timestamp":1791295324759,"version":"4.1.0"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:sec>\n            <jats:title>Objective\u2014<\/jats:title>\n            <jats:p>Overproduction of intestinally derived apoB-48-containing triglyceride-rich lipoproteins (TRLs) (chylomicrons) has recently been described in type 2 diabetes, as is known for hepatic TRL-apoB-100 (very-low-density lipoprotein) production. Furthermore, insulin acutely inhibits both intestinal and hepatic TRL production, whereas this acute inhibitory effect on very-low-density lipoprotein production is blunted in type 2 diabetes. It is not currently known whether this acute effect on chylomicron production is similarly blunted in humans with type 2 diabetes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>We investigated the effect of acute hyperinsulinemia on TRL metabolism in 18 type 2 diabetic men using stable isotope methodology. Each subject underwent 1 control (saline infusion [SAL]) lipoprotein turnover study followed by a second study, under 1 of the 3 following clamp conditions: (1) hyperinsulinemic-euglycemic, (2) hyperinsulinemic-hyperglycemic, or (3) hyperinsulinemic-euglycemic plus intralipid and heparin. TRL-apoB-48 and TRL-apoB-100 production and clearance rates were not different between SAL and clamp and between the different clamp conditions, except for significantly lower TRL-apoB-100 clearance and production rates in hyperinsulinemic-euglycemic plus intralipid and heparin clamp compared with SAL.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion\u2014<\/jats:title>\n            <jats:p>This is the first demonstration in individuals with type 2 diabetes that chylomicron production is resistant to the normal acute suppressive effect of insulin. This phenomenon may contribute to the highly prevalent dyslipidemia of type 2 diabetes and potentially to atherosclerosis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT00950209.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/atvbaha.111.242073","type":"journal-article","created":{"date-parts":[[2012,2,4]],"date-time":"2012-02-04T01:30:17Z","timestamp":1328319017000},"page":"1039-1044","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":49,"title":["Absence of Acute Inhibitory Effect of Insulin on Chylomicron Production in Type 2 Diabetes"],"prefix":"10.1161","volume":"32","author":[{"given":"Juan-Patricio","family":"Nogueira","sequence":"first","affiliation":[{"name":"From the Unit\u00e9 Mixte de Recherche Institut National de la Recherche Agronomique 1260 (J.P.N., M.M., N.P., A.N., R.V.) and Biostatistics Research Unit (Laboratoire d'Enseignement et de Recherche sur le Traitement de l'Information M\u00e9dicale) (J.M.), University of la M\u00e9diterran\u00e9e, Marseille, France; Department of Nutrition, Metabolic Diseases, Endocrinology, Assistance Publique-H\u00f4pitaux de Marseille, La Timone Hospital, Marseille, France (B.V., R.V.); 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Department of Nutrition, Metabolic Diseases, Endocrinology, Assistance Publique-H\u00f4pitaux de Marseille, La Timone Hospital, Marseille, France (B.V., R.V.); Unit\u00e9 Mixte de Recherche Institut National de la..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nad\u00e8ge","family":"Padilla","sequence":"additional","affiliation":[{"name":"From the Unit\u00e9 Mixte de Recherche Institut National de la Recherche Agronomique 1260 (J.P.N., M.M., N.P., A.N., R.V.) and Biostatistics Research Unit (Laboratoire d'Enseignement et de Recherche sur le Traitement de l'Information M\u00e9dicale) (J.M.), University of la M\u00e9diterran\u00e9e, Marseille, France; Department of Nutrition, Metabolic Diseases, Endocrinology, Assistance Publique-H\u00f4pitaux de Marseille, La Timone Hospital, Marseille, France (B.V., R.V.); Unit\u00e9 Mixte de Recherche Institut National de la..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Duvillard","sequence":"additional","affiliation":[{"name":"From the Unit\u00e9 Mixte de Recherche Institut National de la Recherche Agronomique 1260 (J.P.N., M.M., N.P., A.N., R.V.) and Biostatistics Research Unit (Laboratoire d'Enseignement et de Recherche sur le Traitement de l'Information M\u00e9dicale) (J.M.), University of la M\u00e9diterran\u00e9e, Marseille, France; 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