{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:02:05Z","timestamp":1792710125045,"version":"4.5.0"},"reference-count":55,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:p>Deep vein thrombosis and pulmonary embolism are a significant health care concern, representing a major source of mortality and morbidity. In order to understand the pathophysiology of thrombogenesis and thrombus resolution, animal models are necessary. Mouse models of venous thrombosis contribute to our understanding of the initiation, propagation, and resolution of venous thrombus, as well as allow for the evaluation of new pharmaceutical approaches to prophylaxis and treatment of deep vein thrombosis. In this work we review the ferric chloride model, the inferior vena cava ligation model, the inferior vena cava stenosis models, and the electrolytic inferior vena cava model and compare their advantages and disadvantages.<\/jats:p>","DOI":"10.1161\/atvbaha.111.244608","type":"journal-article","created":{"date-parts":[[2012,2,15]],"date-time":"2012-02-15T17:06:16Z","timestamp":1329325576000},"page":"556-562","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":242,"title":["Critical Review of Mouse Models of Venous Thrombosis"],"prefix":"10.1161","volume":"32","author":[{"given":"Jose A.","family":"Diaz","sequence":"first","affiliation":[{"name":"From the Department of Surgery (J.A.D., A.O., D.D.M., S.K.W., P.K.H., T.W.W.), Section of Vascular Surgery, Conrad Jobst Vascular Research Laboratories, and Unit for Laboratory Animal Medicine (D.D.M.), University of Michigan, Ann Arbor, MI; Department of Medicine (N.M.), Division of Hematology\/Oncology, University of North Carolina, Chapel Hill, NC."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea T.","family":"Obi","sequence":"additional","affiliation":[{"name":"From the Department of Surgery (J.A.D., A.O., D.D.M., S.K.W., P.K.H., T.W.W.), Section of Vascular Surgery, Conrad Jobst Vascular Research Laboratories, and Unit for Laboratory Animal Medicine (D.D.M.), University of Michigan, Ann Arbor, MI; Department of Medicine (N.M.), Division of Hematology\/Oncology, University of North Carolina, Chapel Hill, NC."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Daniel D.","family":"Myers","sequence":"additional","affiliation":[{"name":"From the Department of Surgery (J.A.D., A.O., D.D.M., S.K.W., P.K.H., T.W.W.), Section of Vascular Surgery, Conrad Jobst Vascular Research Laboratories, and Unit for Laboratory Animal Medicine (D.D.M.), University of Michigan, Ann Arbor, MI; Department of Medicine (N.M.), Division of Hematology\/Oncology, University of North Carolina, Chapel Hill, NC."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley K.","family":"Wrobleski","sequence":"additional","affiliation":[{"name":"From the Department of Surgery (J.A.D., A.O., D.D.M., S.K.W., P.K.H., T.W.W.), Section of Vascular Surgery, Conrad Jobst Vascular Research Laboratories, and Unit for Laboratory Animal Medicine (D.D.M.), University of Michigan, Ann Arbor, MI; Department of Medicine (N.M.), Division of Hematology\/Oncology, University of North Carolina, Chapel Hill, NC."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter K.","family":"Henke","sequence":"additional","affiliation":[{"name":"From the Department of Surgery (J.A.D., A.O., D.D.M., S.K.W., P.K.H., T.W.W.), Section of Vascular Surgery, Conrad Jobst Vascular Research Laboratories, and Unit for Laboratory Animal Medicine (D.D.M.), University of Michigan, Ann Arbor, MI; Department of Medicine (N.M.), Division of Hematology\/Oncology, University of North Carolina, Chapel Hill, NC."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel","family":"Mackman","sequence":"additional","affiliation":[{"name":"From the Department of Surgery (J.A.D., A.O., D.D.M., S.K.W., P.K.H., T.W.W.), Section of Vascular Surgery, Conrad Jobst Vascular Research Laboratories, and Unit for Laboratory Animal Medicine (D.D.M.), University of Michigan, Ann Arbor, MI; Department of Medicine (N.M.), Division of Hematology\/Oncology, University of North Carolina, Chapel Hill, NC."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas W.","family":"Wakefield","sequence":"additional","affiliation":[{"name":"From the Department of Surgery (J.A.D., A.O., D.D.M., S.K.W., P.K.H., T.W.W.), Section of Vascular Surgery, Conrad Jobst Vascular Research Laboratories, and Unit for Laboratory Animal Medicine (D.D.M.), University of Michigan, Ann Arbor, MI; Department of Medicine (N.M.), Division of Hematology\/Oncology, University of North Carolina, Chapel Hill, NC."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2010.01.010"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2009.01.058"},{"key":"e_1_3_4_4_2","volume-title":"Thrombosis and emboli","author":"Virchow R","year":"1846","unstructured":"Virchow R . Thrombosis and emboli. Canton, MA: Science History Publications, 1846."},{"key":"e_1_3_4_5_2","first-page":"221","article-title":"A survey of venous thrombosis models","volume":"93","author":"Jeske WP","year":"2004","unstructured":"Jeske WP, Iqbal O, Fareed J, Kaiser B . A survey of venous thrombosis models. Methods Mol Med. 2004; 93: 221\u2013 237 .","journal-title":"Methods Mol Med"},{"key":"e_1_3_4_6_2","first-page":"165","article-title":"Animal models useful in the study of thrombosis and antithrombotic agents","volume":"1","author":"Didisheim P","year":"1972","unstructured":"Didisheim P . Animal models useful in the study of thrombosis and antithrombotic agents. Prog Hemost Thromb. 1972; 1: 165\u2013 197 .","journal-title":"Prog Hemost Thromb"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01461.x"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt0103-31"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.2002.6552"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.110.216317"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.162289"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1538-7836.2003.00119.x"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1056-8719(00)00095-2"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/291590a0"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.18.6.908"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1645195"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.19.7585"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(03)01033-4"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2009.10.022"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.15.2.258"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2010.09.003"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.atv.0000129537.72553.73"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-287623"},{"key":"e_1_3_4_24_2","article-title":"Impaired fibrinolytic system in apoe gene-deleted mice with hyperlipidemia augments deep vein thrombosis [epub ahead of print Nov. 23]","author":"Diaz JA","year":"2011","unstructured":"Diaz JA, Ballard-Lipka NE, Farris DM, Hawley AE, Wrobleski SK, Myers DD, Henke PK, Lawrence DA, Wakefield TW . Impaired fibrinolytic system in apoe gene-deleted mice with hyperlipidemia augments deep vein thrombosis [epub ahead of print Nov. 23]. J Vasc Surg. 2011.","journal-title":"J Vasc Surg"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2009.06.047"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2005.04.045"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1177\/096120339400300408"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.10.3322"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-06-028241"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20051732"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-12-4856"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.2.577"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1613739"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.10.1002"},{"key":"e_1_3_4_35_2","first-page":"761","article-title":"Vascular wound healing and neointima formation induced by perivascular electric injury in mice","volume":"150","author":"Carmeliet P","year":"1997","unstructured":"Carmeliet P, Moons L, Stassen JM, De Mol M, Bouche A, van den Oord JJ, Kockx M, Collen D . Vascular wound healing and neointima formation induced by perivascular electric injury in mice. Am J Pathol. 1997; 150: 761\u2013 776 .","journal-title":"Am J Pathol"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00305.2005"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1080\/10739680490425949"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1080\/10739680590925664"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.16.7450"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(90)90106-M"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-01-136820"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2007.12.002"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.109.185678"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000050149.22928.39"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.9.3235"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0967-2109(97)00162-2"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH09-09-0672"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH05-03-0170"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.111.225334"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2011.01.004"},{"key":"e_1_3_4_51_2","first-page":"2737","article-title":"Electrolytic inferior vena cava model (EIM) of venous thrombosis","volume":"53","author":"Diaz JA","year":"2011","unstructured":"Diaz JA, Wrobleski SK, Hawley AE, Lucchesi BR, Wakefield TW, Myers DD . Electrolytic inferior vena cava model (EIM) of venous thrombosis. J Vis Exp. 2011;53:2737 .","journal-title":"J Vis Exp"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1615622"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH07-10-0608"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH06-11-0658"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(97)70211-8"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2006.05.021"}],"container-title":["Arteriosclerosis, Thrombosis, and Vascular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/ATVBAHA.111.244608","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T19:12:47Z","timestamp":1715541167000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/ATVBAHA.111.244608"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":55,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["10.1161\/ATVBAHA.111.244608"],"URL":"https:\/\/doi.org\/10.1161\/atvbaha.111.244608","relation":{},"ISSN":["1079-5642","1524-4636"],"issn-type":[{"value":"1079-5642","type":"print"},{"value":"1524-4636","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3]]},"assertion":[{"value":"2011-12-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-01-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-03-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}