{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:11:21Z","timestamp":1791216681800,"version":"4.1.0"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:sec>\n            <jats:title>Objective\u2014<\/jats:title>\n            <jats:p>Smooth muscle progenitor cells (SMPCs) were intriguingly shown to act as a double-edged sword in the pathogenesis of atherosclerosis. To fully clarify the roles of SMPCs in atherosclerosis, a distinct panel of SMPC surface markers is mandatory to be developed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              Microarray gene expression analyses were used to discover potential surface markers of SMPCs. In vitro and in vivo experiments documented that platelet-derived growth factor receptor-\u03b2, carboxypeptidase M, carbonic anhydrase 12, receptor activity-modifying protein 1, and low-density lipoprotein receptor\u2013related protein were the 5 specific surface markers regulating various SMPC functions, including migration, extracellular matrix formation, resistance to hypoxia, and anti-inflammation. In s\n              <jats:italic>evere combined immunodeficiency<\/jats:italic>\n              \/nonobese diabetic mice after femoral arterial wire injury, injected human peripheral blood mononuclear cells contributed to substantial amount of neointimal \u03b1-smooth muscle actin-positive cells, coexpressing platelet-derived growth factor receptor-\u03b2, carboxypeptidase M, carbonic anhydrase 12, receptor activity-modifying protein 1, and low-density lipoprotein receptor\u2013related protein. Based on these markers, a novel quantification assay was developed to enumerate circulating early SMPC. Early SMPC numbers were higher in patients with unstable angina compared with those with normal coronary angiograms. In patients with acute ST-elevation myocardial infarction, different patterns of serial early SMPC changes were noted, related to different clinical presentations.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion\u2014<\/jats:title>\n            <jats:p>Surface markers of heterogeneous SMPCs exhibit various functions associated with atherosclerotic pathophysiology. Quantification of surface marker\u2013defined SMPCs provides a platform for studying SMPCs in cardiovascular diseases.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/atvbaha.112.245852","type":"journal-article","created":{"date-parts":[[2012,6,8]],"date-time":"2012-06-08T04:21:00Z","timestamp":1339129260000},"page":"1875-1883","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":21,"title":["Surface Markers of Heterogeneous Peripheral Blood\u2013Derived Smooth Muscle Progenitor Cells"],"prefix":"10.1161","volume":"32","author":[{"given":"Chao-Hung","family":"Wang","sequence":"first","affiliation":[{"name":"From the Heart Failure Center, Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Keelung, Taiwan (C.-H.W., H.-F. M., S.-Y.L., M.-H.L., W.-J.C.); Department of Pathology, Chang Gung University College of Medicine, Taoyuan, Taiwan (J.-R.C.); Department of Biotechnology, Ming Chuan University, Taoyuan, Taiwan (Y.-S.L.); and Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan (S.-J.L., C.-H.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Shien","family":"Lee","sequence":"additional","affiliation":[{"name":"From the Heart Failure Center, Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Keelung, Taiwan (C.-H.W., H.-F. M., S.-Y.L., M.-H.L., W.-J.C.); Department of Pathology, Chang Gung University College of Medicine, Taoyuan, Taiwan (J.-R.C.); Department of Biotechnology, Ming Chuan University, Taoyuan, Taiwan (Y.-S.L.); and Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan (S.-J.L., C.-H.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shing-Jong","family":"Lin","sequence":"additional","affiliation":[{"name":"From the Heart Failure Center, Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Keelung, Taiwan (C.-H.W., H.-F. M., S.-Y.L., M.-H.L., W.-J.C.); Department of Pathology, Chang Gung University College of Medicine, Taoyuan, Taiwan (J.-R.C.); Department of Biotechnology, Ming Chuan University, Taoyuan, Taiwan (Y.-S.L.); and Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan (S.-J.L., C.-H.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiu-Fu","family":"Mei","sequence":"additional","affiliation":[{"name":"From the Heart Failure Center, Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Keelung, Taiwan (C.-H.W., H.-F. M., S.-Y.L., M.-H.L., W.-J.C.); Department of Pathology, Chang Gung University College of Medicine, Taoyuan, Taiwan (J.-R.C.); Department of Biotechnology, Ming Chuan University, Taoyuan, Taiwan (Y.-S.L.); and Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan (S.-J.L., C.-H.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Yuan","family":"Lin","sequence":"additional","affiliation":[{"name":"From the Heart Failure Center, Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Keelung, Taiwan (C.-H.W., H.-F. M., S.-Y.L., M.-H.L., W.-J.C.); Department of Pathology, Chang Gung University College of Medicine, Taoyuan, Taiwan (J.-R.C.); Department of Biotechnology, Ming Chuan University, Taoyuan, Taiwan (Y.-S.L.); and Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan (S.-J.L., C.-H.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Hui","family":"Liu","sequence":"additional","affiliation":[{"name":"From the Heart Failure Center, Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Keelung, Taiwan (C.-H.W., H.-F. M., S.-Y.L., M.-H.L., W.-J.C.); Department of Pathology, Chang Gung University College of Medicine, Taoyuan, Taiwan (J.-R.C.); Department of Biotechnology, Ming Chuan University, Taoyuan, Taiwan (Y.-S.L.); and Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan (S.-J.L., C.-H.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim-Ray","family":"Chen","sequence":"additional","affiliation":[{"name":"From the Heart Failure Center, Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Keelung, Taiwan (C.-H.W., H.-F. 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