{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:12:40Z","timestamp":1790233960118,"version":"4.1.0"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:sec>\n            <jats:title>Objectives\u2014<\/jats:title>\n            <jats:p>Obesity promotes hypertension, but it is unclear if sex differences exist in obesity-related hypertension. Angiotensin converting enzyme 2 (ACE2) converts angiotensin II (AngII) to angiotensin-(1\u20137) (Ang-[1\u20137]), controlling peptide balance. We hypothesized that tissue-specific regulation of ACE2 by high-fat (HF) feeding and sex hormones contributes to sex differences in obesity-hypertension.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>HF-fed females gained more body weight and fat mass than males. HF-fed males exhibiting reduced kidney ACE2 activity had increased plasma angiotensin II levels and decreased plasma Ang-(1\u20137) levels. In contrast, HF-fed females exhibiting elevated adipose ACE2 activity had increased plasma Ang-(1\u20137) levels. HF-fed males had elevated systolic and diastolic blood pressure that were abolished by losartan. In contrast, HF-fed females did not exhibit increased systolic blood pressure until females were administered the Ang-(1\u20137) receptor antagonist, D-Ala-Ang-(1\u20137). Deficiency of ACE2 increased systolic blood pressure in HF-fed males and females, which was abolished by losartan. Ovariectomy of HF-fed female mice reduced adipose ACE2 activity and plasma Ang-(1\u20137) levels, and promoted obesity-hypertension. Finally, estrogen, but not other sex hormones, increased adipocyte ACE2 mRNA abundance.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>These results demonstrate that tissue-specific regulation of ACE2 by diet and sex hormones contributes to sex differences in obesity-hypertension.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/atvbaha.112.248559","type":"journal-article","created":{"date-parts":[[2012,3,30]],"date-time":"2012-03-30T04:42:38Z","timestamp":1333082558000},"page":"1392-1399","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":185,"title":["Angiotensin Converting Enzyme 2 Contributes to Sex Differences in the Development of Obesity Hypertension in C57BL\/6 Mice"],"prefix":"10.1161","volume":"32","author":[{"given":"Manisha","family":"Gupte","sequence":"first","affiliation":[{"name":"From the Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY (M.G., S.E.T., C.M.B.K., R.S., F.Y., X.Z., M.K., L.A.C)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean E.","family":"Thatcher","sequence":"additional","affiliation":[{"name":"From the Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY (M.G., S.E.T., C.M.B.K., R.S., F.Y., X.Z., M.K., L.A.C)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine M.","family":"Boustany-Kari","sequence":"additional","affiliation":[{"name":"From the Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY (M.G., S.E.T., C.M.B.K., R.S., F.Y., X.Z., M.K., L.A.C)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Shoemaker","sequence":"additional","affiliation":[{"name":"From the Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY (M.G., S.E.T., C.M.B.K., R.S., F.Y., X.Z., M.K., L.A.C)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederique","family":"Yiannikouris","sequence":"additional","affiliation":[{"name":"From the Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY (M.G., S.E.T., C.M.B.K., R.S., F.Y., X.Z., M.K., L.A.C)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"From the Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY (M.G., S.E.T., C.M.B.K., R.S., F.Y., X.Z., M.K., L.A.C)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Karounos","sequence":"additional","affiliation":[{"name":"From the Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY (M.G., S.E.T., C.M.B.K., R.S., F.Y., X.Z., M.K., L.A.C)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa A.","family":"Cassis","sequence":"additional","affiliation":[{"name":"From the Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY (M.G., S.E.T., C.M.B.K., R.S., F.Y., X.Z., M.K., L.A.C)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","first-page":"27","article-title":"The Framingham Study: historical insight on the impact of cardiovascular risk factors in men versus women.","volume":"5","author":"Kannel WB","year":"2002","unstructured":"Kannel WB. 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