{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:28:47Z","timestamp":1791498527547,"version":"4.3.4"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:sec>\n            <jats:title>Objective\u2014<\/jats:title>\n            <jats:p>Vitamin D deficiency is common and associated with dyslipidemia. However, it is unclear whether oral vitamin D supplementation improves the lipid profile. Therefore, we conducted a randomized, placebo-controlled trial to determine the short-term effects of vitamin D repletion on the lipid profile.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              One hundred fifty-one vitamin D\u2212deficient (25-hydroxyvitamin D &lt;20 ng\/mL) adults with elevated risk for cardiovascular disease were randomized to receive either 50 000 IU of vitamin D3 weekly for 8 weeks or placebo. The primary outcome was the change in small low-density lipoprotein (LDL) particle number. Secondary outcomes included changes in other n\n              <jats:italic>uclear magnetic resonance<\/jats:italic>\n              \u2212based and chemical lipid fractions. Vitamin D failed to improve the lipid profile. Compared with the placebo, vitamin D repletion did not change small LDL particle number (mean change, +18 nmol\/L; 95% CI [\u221280 to +116 nmol\/L];\n              <jats:italic>P<\/jats:italic>\n              =0.63). There were also no changes in the chemical lipid profile: total cholesterol (+5.8 mg\/dL, 95% CI [\u22121.4 to +13.0 mg\/dL],\n              <jats:italic>P<\/jats:italic>\n              =0.14); LDL cholesterol (+3.8 mg\/dL, 95% CI [\u22122.5 to +10.2 mg\/dL],\n              <jats:italic>P<\/jats:italic>\n              =0.13); high\u2013density lipoprotein cholesterol (+0.4 mg\/dL 95% CI [\u22121.6 to +2.6 mg\/dL],\n              <jats:italic>P<\/jats:italic>\n              =0.71); and triglycerides (+7.9 mg\/dL 95% CI [\u22126.5 to +22.3 mg\/dL]). In the vitamin D repletion group, exploratory multivariate regression analysis demonstrates that changes in LDL cholesterol were positively correlated with the changes in serum calcium (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and inversely with the changes in serum parathyroid hormone (\n              <jats:italic>P<\/jats:italic>\n              =0.02).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion\u2014<\/jats:title>\n            <jats:p>In contrast to the association between low 25-hydroxyvitamin D levels and dyslipidemia, correcting vitamin D deficiency in the short-term does not improve the lipid profile. Repletion of 25-hydroxyvitamin D levels raised serum calcium levels and decreased serum parathyroid hormone levels. These expected physiological responses to vitamin D therapy were correlated with a significant increase in LDL cholesterol.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT01008384.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/atvbaha.112.254110","type":"journal-article","created":{"date-parts":[[2012,9,5]],"date-time":"2012-09-05T06:54:22Z","timestamp":1346828062000},"page":"2510-2515","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":77,"title":["The Short-Term Effects of Vitamin D Repletion on Cholesterol"],"prefix":"10.1161","volume":"32","author":[{"given":"Manish P.","family":"Ponda","sequence":"first","affiliation":[{"name":"From the Laboratory of Biochemical Genetics and Metabolism (M.P.P., P.R.H., J.L.B.) and the Center for Clinical and Translational Science (K.D.), The Rockefeller University, New York, NY; and Beth Israel Medical Center, New York, NY (D.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Dowd","sequence":"additional","affiliation":[{"name":"From the Laboratory of Biochemical Genetics and Metabolism (M.P.P., P.R.H., J.L.B.) and the Center for Clinical and Translational Science (K.D.), The Rockefeller University, New York, NY; and Beth Israel Medical Center, New York, NY (D.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Finkielstein","sequence":"additional","affiliation":[{"name":"From the Laboratory of Biochemical Genetics and Metabolism (M.P.P., P.R.H., J.L.B.) and the Center for Clinical and Translational Science (K.D.), The Rockefeller University, New York, NY; and Beth Israel Medical Center, New York, NY (D.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter R.","family":"Holt","sequence":"additional","affiliation":[{"name":"From the Laboratory of Biochemical Genetics and Metabolism (M.P.P., P.R.H., J.L.B.) and the Center for Clinical and Translational Science (K.D.), The Rockefeller University, New York, NY; and Beth Israel Medical Center, New York, NY (D.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan L.","family":"Breslow","sequence":"additional","affiliation":[{"name":"From the Laboratory of Biochemical Genetics and Metabolism (M.P.P., P.R.H., J.L.B.) and the Center for Clinical and Translational Science (K.D.), The Rockefeller University, New York, NY; and Beth Israel Medical Center, New York, NY (D.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0385"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra070553"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2704"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2003.10719287"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/80.6.1689S"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0215219"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114097"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2008.06.067"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.107.706127"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.107.087288"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1988.00380010040006"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.108.809582"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.167.11.1159"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.111.077875"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-6-199903160-00002"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/18.6.499"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2010.09.018"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.881"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2009.18"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03347358"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1370495"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.3109\/09637486.2010.536146"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2008.02636.x"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.28579"},{"key":"e_1_3_3_26_2","first-page":"640","article-title":"Effect of winter oral vitamin D3 supplementation on cardiovascular risk factors in elderly adults.","volume":"49","author":"Scragg R","year":"1995","unstructured":"Scragg R, Khaw KT, Murphy S. 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