{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T08:08:53Z","timestamp":1775808533382,"version":"3.50.1"},"reference-count":61,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:sec><jats:title>Objective\u2014<\/jats:title><jats:p>MicroRNAs play a role in atherosclerosis-related diseases, such as cerebrovascular or cardiovascular disease. However, the effect of<jats:italic>miR-146a<\/jats:italic>,<jats:italic>miR-149<\/jats:italic>,<jats:italic>miR-196a2<\/jats:italic>, and<jats:italic>miR-499<\/jats:italic>polymorphisms on stroke and silent brain infarction (SBI) susceptibility has not been reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results\u2014<\/jats:title><jats:p>Using polymerase chain reaction-amplified DNA, microRNA polymorphisms were analyzed in 678 patients with ischemic stroke, 373 patients with SBI, and 553 control subjects. The<jats:italic>miR-146a<\/jats:italic>C&gt;G polymorphism and<jats:italic>miR-146a<\/jats:italic>G\/<jats:italic>-149<\/jats:italic>T\/<jats:italic>-196a2<\/jats:italic>C\/<jats:italic>-499<\/jats:italic>G allele combination was significantly associated with ischemic stroke prevalence. For SBI prevalence, there were no statistically significant genetic markers. However, some allele combinations were associated with increased SBI incidence (C-T-C-G and G-T-T-A of<jats:italic>miR-146a<\/jats:italic>\/<jats:italic>-149<\/jats:italic>\/<jats:italic>-196a2<\/jats:italic>\/<jats:italic>-499<\/jats:italic>). In subgroup analyses,<jats:italic>miR-146a<\/jats:italic>C&gt;G increased stroke risk in female, normotensive, and nondiabetic groups. There were significant combined effects between microRNA polymorphisms and homocysteine\/folate levels on ischemic stroke and SBI prevalence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion\u2014<\/jats:title><jats:p>The<jats:italic>miR-146a<\/jats:italic>G allele and<jats:italic>miR-146a<\/jats:italic>G\/<jats:italic>-149<\/jats:italic>T\/<jats:italic>-196a2<\/jats:italic>C\/<jats:italic>-499<\/jats:italic>G allele combination were associated with ischemic stroke pathogenesis. The combined effects between microRNA polymorphisms and homocysteine\/folate levels may contribute to stroke and SBI prevalence.<\/jats:p><\/jats:sec>","DOI":"10.1161\/atvbaha.112.300251","type":"journal-article","created":{"date-parts":[[2012,11,30]],"date-time":"2012-11-30T07:24:39Z","timestamp":1354260279000},"page":"420-430","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":111,"title":["Association of the<i>miR-146a<\/i>,<i>miR-149<\/i>,<i>miR-196a2<\/i>, and<i>miR-499<\/i>Polymorphisms With Ischemic Stroke and Silent Brain Infarction Risk"],"prefix":"10.1161","volume":"33","author":[{"given":"Young Joo","family":"Jeon","sequence":"first","affiliation":[{"name":"From the Institute for Clinical Research (Y.J.J., S.Y.K., D.O., N.K.K.), Department of Neurology (O.J.K., S.H.O.), Department of Emergency Medicine (O.J.K.), CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea and Department of 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