{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T17:42:53Z","timestamp":1773423773595,"version":"3.50.1"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:sec>\n            <jats:title>Objective\u2014<\/jats:title>\n            <jats:p>Elevated levels of advanced oxidation protein products have been described in several chronic inflammatory diseases, like chronic renal insufficiency, rheumatoid arthritis, and atherosclerosis. Recent findings revealed that advanced oxidation protein products are inhibitors of the major high\u2013density lipoprotein receptor, scavenger receptor class B, type 1 (SR-BI). Here, we investigated which oxidation-induced structural alterations convert plasma albumin into a high-density lipoprotein\u2013receptor inhibitor.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Approach and Results\u2014<\/jats:title>\n            <jats:p>\n              Exposure of albumin to the physiological oxidant, hypochlorous acid, generated high-affinity SR-BI ligands. Protection of albumin\u2013lysine residues before exposure to hypochlorous acid as well as regeneration of\n              <jats:italic>N<\/jats:italic>\n              -chloramines after oxidation of albumin completely prevented binding of oxidized albumin to SR-BI, indicating that modification of albumin\u2013lysine residues is required to generate SR-BI ligands. Of particular interest,\n              <jats:italic>N<\/jats:italic>\n              -chloramines within oxidized albumin promoted irreversible binding to SR-BI, resulting in permanent receptor blockade. We observed that the SR-BI inhibitory activity of albumin isolated from chronic kidney disease patients correlated with the content of the myeloperoxidase-specific oxidation product 3-chlorotyrosine and was associated with alterations in the composition of high-density lipoprotein.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Given that several potential atheroprotective activities of high-density lipoprotein are mediated by SR-BI, the present results raise the possibility that oxidized plasma albumin, through permanent SR-BI blockade, contributes to the pathophysiology of cardiovascular disease.<\/jats:p>\n          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Institute of Experimental and Clinical Pharmacology (V.B., M.H., D.E.-G., R.S., A.H., G.M.), Division of Cardiology (S.L., B.P.), and Institute of Pathology (J.H.), Medical University of Graz, Graz, Austria."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolf","family":"Schicho","sequence":"additional","affiliation":[{"name":"From the Institute of Experimental and Clinical Pharmacology (V.B., M.H., D.E.-G., R.S., A.H., G.M.), Division of Cardiology (S.L., B.P.), and Institute of Pathology (J.H.), Medical University of Graz, Graz, Austria."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burkert","family":"Pieske","sequence":"additional","affiliation":[{"name":"From the Institute of Experimental and Clinical Pharmacology (V.B., M.H., D.E.-G., R.S., A.H., G.M.), Division of Cardiology (S.L., B.P.), and Institute of Pathology (J.H.), Medical University of Graz, Graz, 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