{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:38:31Z","timestamp":1790804311801,"version":"4.1.0"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:sec>\n            <jats:title>Objective\u2014<\/jats:title>\n            <jats:p>Haplogroup I of male-specific region of the human Y chromosome is associated with 50% increased risk of coronary artery disease. It is not clear to what extent conventional cardiovascular risk factors and genes of the male-specific region may explain this association.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Approach and Results\u2014<\/jats:title>\n            <jats:p>\n              A total of 1988 biologically unrelated men from 4 white European populations were genotyped using 11 Y chromosome single nucleotide polymorphisms and classified into 13 most common European haplogroups. Approximately 75% to 93% of the haplotypic variation of the Y chromosome in all cohorts was attributable to I, R1a, and R1b1b2 lineages. None of traditional cardiovascular risk factors, including body mass index, blood pressures, lipids, glucose, C-reactive protein, creatinine, and insulin resistance, was associated with haplogroup I of the Y chromosome in the joint inverse variance meta-analysis. Fourteen of 15 ubiquitous single-copy genes of the male-specific region were expressed in human macrophages. When compared with men with other haplogroups, carriers of haplogroup I had \u22480.61- and 0.64-fold lower expression of ubiquitously transcribed tetratricopeptide repeat, Y-linked gene (\n              <jats:italic>UTY<\/jats:italic>\n              ) and protein kinase, Y-linked, pseudogene (\n              <jats:italic>PRKY<\/jats:italic>\n              ) in macrophages (\n              <jats:italic>P<\/jats:italic>\n              =0.0001 and\n              <jats:italic>P<\/jats:italic>\n              =0.002, respectively).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>\n              Coronary artery disease predisposing haplogroup I of the Y chromosome is associated with downregulation of\n              <jats:italic>UTY<\/jats:italic>\n              and\n              <jats:italic>PRKY<\/jats:italic>\n              genes in macrophages but not with conventional cardiovascular risk factors.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/atvbaha.113.301608","type":"journal-article","created":{"date-parts":[[2013,5,3]],"date-time":"2013-05-03T07:52:21Z","timestamp":1367567541000},"page":"1722-1727","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":67,"title":["Male-Specific Region of the Y Chromosome and Cardiovascular Risk"],"prefix":"10.1161","volume":"33","author":[{"given":"Lisa D.S.","family":"Bloomer","sequence":"first","affiliation":[{"name":"From the Department of Cardiovascular Sciences (L.D.S.B., C.P.N., J.E., M.D., P.C., R.D., J.M., A.H.G., N.J.S., F.J.C., M.T.) and Department of Health Sciences (J.T.), University of Leicester, Leicester, United Kingdom; Leicester National Institute for Health Research Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, United Kingdom (C.P.N., A.H.G., J.T., N.J.S., M.T.); Department of Internal Medicine, Diabetology, and Nephrology, Medical University of Silesia, Zabrze..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher P.","family":"Nelson","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Sciences (L.D.S.B., C.P.N., J.E., M.D., P.C., R.D., J.M., A.H.G., N.J.S., F.J.C., M.T.) and Department of Health Sciences (J.T.), University of Leicester, Leicester, United Kingdom; Leicester National Institute for Health Research Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, United Kingdom (C.P.N., A.H.G., J.T., N.J.S., M.T.); Department of Internal Medicine, Diabetology, and Nephrology, Medical University of Silesia, Zabrze..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Eales","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Sciences (L.D.S.B., C.P.N., J.E., M.D., P.C., R.D., J.M., A.H.G., N.J.S., F.J.C., M.T.) and Department of Health Sciences (J.T.), University of Leicester, Leicester, United Kingdom; Leicester National Institute for Health Research Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, United Kingdom (C.P.N., A.H.G., J.T., N.J.S., M.T.); Department of Internal Medicine, Diabetology, and Nephrology, Medical University of Silesia, Zabrze..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Denniff","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Sciences (L.D.S.B., C.P.N., J.E., M.D., P.C., R.D., J.M., A.H.G., N.J.S., F.J.C., M.T.) and Department of Health Sciences (J.T.), University of Leicester, Leicester, United Kingdom; Leicester National Institute for Health Research Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, United Kingdom (C.P.N., A.H.G., J.T., N.J.S., M.T.); Department of Internal Medicine, Diabetology, and Nephrology, Medical University of Silesia, Zabrze..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paraskevi","family":"Christofidou","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Sciences (L.D.S.B., C.P.N., J.E., M.D., P.C., R.D., J.M., A.H.G., N.J.S., F.J.C., M.T.) and Department of Health Sciences (J.T.), University of Leicester, Leicester, United Kingdom; Leicester National Institute for Health Research Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, United Kingdom (C.P.N., A.H.G., J.T., N.J.S., M.T.); Department of Internal Medicine, Diabetology, and Nephrology, Medical University of Silesia, Zabrze..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radoslaw","family":"Debiec","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Sciences (L.D.S.B., C.P.N., J.E., M.D., P.C., R.D., J.M., A.H.G., N.J.S., F.J.C., M.T.) and Department of Health Sciences (J.T.), University of Leicester, Leicester, United Kingdom; Leicester National Institute for Health Research Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, United Kingdom (C.P.N., A.H.G., J.T., N.J.S., M.T.); Department of Internal Medicine, Diabetology, and Nephrology, Medical University of Silesia, Zabrze..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasbir","family":"Moore","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Sciences (L.D.S.B., C.P.N., J.E., M.D., P.C., R.D., J.M., A.H.G., N.J.S., F.J.C., M.T.) and Department of Health Sciences (J.T.), University of Leicester, Leicester, United Kingdom; Leicester National Institute for Health Research Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, United Kingdom (C.P.N., A.H.G., J.T., N.J.S., M.T.); Department of Internal Medicine, Diabetology, and Nephrology, Medical University of Silesia, Zabrze..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cardiogenics","family":"Consortium","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Sciences (L.D.S.B., C.P.N., J.E., M.D., P.C., R.D., J.M., A.H.G., N.J.S., F.J.C., M.T.) and Department of Health Sciences (J.T.), University of Leicester, Leicester, United Kingdom; Leicester National Institute for Health Research Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, United Kingdom (C.P.N., A.H.G., J.T., N.J.S., M.T.); Department of Internal Medicine, Diabetology, and Nephrology, Medical University of Silesia, Zabrze..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Zukowska-Szczechowska","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Sciences (L.D.S.B., C.P.N., J.E., M.D., P.C., R.D., J.M., A.H.G., N.J.S., F.J.C., M.T.) and Department of Health Sciences (J.T.), University of Leicester, Leicester, United Kingdom; Leicester National Institute for Health Research Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, United Kingdom (C.P.N., A.H.G., J.T., N.J.S., M.T.); Department of Internal Medicine, Diabetology, and Nephrology, Medical University of Silesia, Zabrze..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison H.","family":"Goodall","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Sciences (L.D.S.B., C.P.N., J.E., M.D., P.C., R.D., J.M., A.H.G., N.J.S., F.J.C., M.T.) and Department of Health Sciences (J.T.), University of Leicester, Leicester, United Kingdom; Leicester National Institute for Health Research Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, United Kingdom (C.P.N., A.H.G., J.T., N.J.S., M.T.); Department of Internal Medicine, Diabetology, and Nephrology, Medical University of Silesia, Zabrze..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Thompson","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Sciences (L.D.S.B., C.P.N., J.E., M.D., P.C., R.D., J.M., A.H.G., N.J.S., F.J.C., M.T.) and Department of Health Sciences (J.T.), University of Leicester, Leicester, United Kingdom; Leicester National Institute for Health Research Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, United Kingdom (C.P.N., A.H.G., J.T., N.J.S., M.T.); Department of Internal Medicine, Diabetology, and Nephrology, Medical University of Silesia, Zabrze..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilesh J.","family":"Samani","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Sciences (L.D.S.B., C.P.N., J.E., M.D., P.C., R.D., J.M., A.H.G., N.J.S., F.J.C., M.T.) and Department of Health Sciences (J.T.), University of Leicester, Leicester, United Kingdom; Leicester National Institute for Health Research Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, United Kingdom (C.P.N., A.H.G., J.T., N.J.S., M.T.); Department of Internal Medicine, Diabetology, and Nephrology, Medical University of Silesia, Zabrze..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadi J.","family":"Charchar","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Sciences (L.D.S.B., C.P.N., J.E., M.D., P.C., R.D., J.M., A.H.G., N.J.S., F.J.C., M.T.) and Department of Health Sciences (J.T.), University of Leicester, Leicester, United Kingdom; Leicester National Institute for Health Research Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, United Kingdom (C.P.N., A.H.G., J.T., N.J.S., M.T.); Department of Internal Medicine, Diabetology, and Nephrology, Medical University of Silesia, Zabrze..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Tomaszewski","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Sciences (L.D.S.B., C.P.N., J.E., M.D., P.C., R.D., J.M., A.H.G., N.J.S., F.J.C., M.T.) and Department of Health Sciences (J.T.), University of Leicester, Leicester, United Kingdom; Leicester National Institute for Health Research Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, United Kingdom (C.P.N., A.H.G., J.T., N.J.S., M.T.); Department of Internal Medicine, Diabetology, and Nephrology, Medical University of Silesia, Zabrze..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01722"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-2760(03)00032-8"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/hy0202.103413"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.36.5.731"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.atv.0000113291.39267.0a"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61453-0"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002160"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.110.155721"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2009.06.003"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.217602"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.7172008"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/155.2.945"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/164.4.1567"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-8286.2007.01758.x"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-0998.2009.02591.x"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.04.028"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.12.1327-b"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-008-0620-7"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.111.241885"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000191904.26853.b8"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c4986"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.167.22.2490"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/362801a0"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209436"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.132051799"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.5.2807"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.9.3126"}],"container-title":["Arteriosclerosis, Thrombosis, and Vascular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/ATVBAHA.113.301608","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T23:00:01Z","timestamp":1715554801000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/ATVBAHA.113.301608"}},"subtitle":["Phylogenetic Analysis and Gene Expression Studies"],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":27,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1161\/ATVBAHA.113.301608"],"URL":"https:\/\/doi.org\/10.1161\/atvbaha.113.301608","relation":{},"ISSN":["1079-5642","1524-4636"],"issn-type":[{"value":"1079-5642","type":"print"},{"value":"1524-4636","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7]]},"assertion":[{"value":"2012-10-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-04-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-05-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}