{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T02:34:41Z","timestamp":1792722881252,"version":"4.5.0"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:sec>\n            <jats:title>Objective\u2014<\/jats:title>\n            <jats:p>Dimethylglycine is linked to lipid metabolism, and increased plasma levels may be associated with adverse prognosis in patients with coronary artery disease. We evaluated the relationship between plasma dimethylglycine and risk of incident acute myocardial infarction in a large prospective cohort of patients with stable angina pectoris, of whom approximately two thirds were participants in a B-vitamin intervention trial. Model discrimination and reclassification when adding plasma dimethylglycine to established risk factors were obtained. We also explored temporal changes and the test\u2013retest reliability of plasma dimethylglycine.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Approach and Results\u2014<\/jats:title>\n            <jats:p>\n              Four thousand one hundred fifty patients (72% men; median age 62 years) were included. Plasma dimethylglycine was associated with several traditional coronary artery disease risk factors. During a median follow-up of 4.6 years, 343 (8.3%) patients experienced an acute myocardial infarction. The hazard ratio (95% confidence interval) for acute myocardial infarction was 1.95 (1.42\u20132.68;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) when comparing plasma dimethylglycine quartile 4 to 1 in a Cox regression model adjusted for age, sex, and fasting status. Adjusting for traditional coronary artery disease risk factors only slightly modified the estimates, which were particularly strong among nonsmokers and among patients with serum triglyceride or apolipoprotein B100 levels \u2264median (\n              <jats:italic>P<\/jats:italic>\n              for interaction=0.004, 0.004, and 0.03, respectively). Plasma dimethylglycine improved discrimination and reclassification and had high test\u2013retest reliability.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Plasma dimethylglycine is independently related to incident acute myocardial infarction and enhances risk prediction in patients with stable angina pectoris. Our results motivate further studies on the relationship between 1-carbon metabolism and atherothrombosis. A potential interplay with lipid and energy metabolism merits particular attention.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/atvbaha.113.301714","type":"journal-article","created":{"date-parts":[[2013,5,31]],"date-time":"2013-05-31T06:02:46Z","timestamp":1369980166000},"page":"2041-2048","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":92,"title":["Plasma Dimethylglycine and Risk of Incident Acute Myocardial Infarction in Patients With Stable Angina Pectoris"],"prefix":"10.1161","volume":"33","author":[{"given":"Gard Frodahl","family":"Tveitev\u00e5g Svingen","sequence":"first","affiliation":[{"name":"From the Department of Clinical Science (G.F.T.S., E.K.R.P., P.M.U., K.H.L., O.N.), Department of Global Public Health and Primary Care (G.S.T.), University of Bergen, Bergen, Norway; Department of Heart Disease, Haukeland University Hospital, Bergen, Norway (H.S.H., R.S., O.N.); and Norwegian Cardiovascular Disease Registry, Norwegian Institute of Public Health, Oslo, Norway (M.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per Magne","family":"Ueland","sequence":"additional","affiliation":[{"name":"From the Department of Clinical Science (G.F.T.S., E.K.R.P., P.M.U., K.H.L., O.N.), Department of Global Public Health and Primary Care (G.S.T.), University of Bergen, Bergen, Norway; Department of Heart Disease, Haukeland University Hospital, Bergen, Norway (H.S.H., R.S., O.N.); and Norwegian Cardiovascular Disease Registry, Norwegian Institute of Public Health, Oslo, Norway (M.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva Kristine Ringdal","family":"Pedersen","sequence":"additional","affiliation":[{"name":"From the Department of Clinical Science (G.F.T.S., E.K.R.P., P.M.U., K.H.L., O.N.), Department of Global Public Health and Primary Care (G.S.T.), University of Bergen, Bergen, Norway; Department of Heart Disease, Haukeland University Hospital, Bergen, Norway (H.S.H., R.S., O.N.); and Norwegian Cardiovascular Disease Registry, Norwegian Institute of Public Health, Oslo, Norway (M.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hall","family":"Schartum-Hansen","sequence":"additional","affiliation":[{"name":"From the Department of Clinical Science (G.F.T.S., E.K.R.P., P.M.U., K.H.L., O.N.), Department of Global Public Health and Primary Care (G.S.T.), University of Bergen, Bergen, Norway; Department of Heart Disease, Haukeland University Hospital, Bergen, Norway (H.S.H., R.S., O.N.); and Norwegian Cardiovascular Disease Registry, Norwegian Institute of Public Health, Oslo, Norway (M.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"Seifert","sequence":"additional","affiliation":[{"name":"From the Department of Clinical Science (G.F.T.S., E.K.R.P., P.M.U., K.H.L., O.N.), Department of Global Public Health and Primary Care (G.S.T.), University of Bergen, Bergen, Norway; Department of Heart Disease, Haukeland University Hospital, Bergen, Norway (H.S.H., R.S., O.N.); and Norwegian Cardiovascular Disease Registry, Norwegian Institute of Public Health, Oslo, Norway (M.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Ebbing","sequence":"additional","affiliation":[{"name":"From the Department of Clinical Science (G.F.T.S., E.K.R.P., P.M.U., K.H.L., O.N.), Department of Global Public Health and Primary Care (G.S.T.), University of Bergen, Bergen, Norway; Department of Heart Disease, Haukeland University Hospital, Bergen, Norway (H.S.H., R.S., O.N.); and Norwegian Cardiovascular Disease Registry, Norwegian Institute of Public Health, Oslo, Norway (M.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kjetil Halvorsen","family":"L\u00f8land","sequence":"additional","affiliation":[{"name":"From the Department of Clinical Science (G.F.T.S., E.K.R.P., P.M.U., K.H.L., O.N.), Department of Global 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