{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T02:49:40Z","timestamp":1790045380466,"version":"4.0.1"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec>\n            <jats:title>Objective\u2014<\/jats:title>\n            <jats:p>\n              To investigate the role of bone morphogenetic proteins (BMPs) on \u03b1-B-crystallin (\n              <jats:italic>CRYAB<\/jats:italic>\n              ) expression and its physiological consequences on endothelial cells (ECs).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Approach and Results\u2014<\/jats:title>\n            <jats:p>\n              We report that the gene encoding for the small heat shock protein,\n              <jats:italic>CRYAB<\/jats:italic>\n              , is a transcriptional target of the BMP signaling pathway. We demonstrate that\n              <jats:italic>CRYAB<\/jats:italic>\n              expression is upregulated strongly by BMPs in an EC line and in human lung microvascular ECs and human umbilical vein ECs. We show that BMP signals through the BMPR2-ALK1 pathway to upregulate\n              <jats:italic>CRYAB<\/jats:italic>\n              expression through a transcriptional indirect mechanism involving Id1. We observed that the known antiapoptotic effect of the BMPs is, in part, because of the upregulation of\n              <jats:italic>CRYAB<\/jats:italic>\n              expression in EC. We also show that\n              <jats:italic>cryab<\/jats:italic>\n              is downregulated in vivo, in a mouse model of pulmonary arterial hypertension induced by chronic hypoxia where the BMP pathway is downregulated.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>We demonstrate a cross-talk between BMPs and CRYAB and a major effect of this regulatory interaction on resistance to apoptosis.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/atvbaha.113.301976","type":"journal-article","created":{"date-parts":[[2013,9,27]],"date-time":"2013-09-27T05:20:10Z","timestamp":1380259210000},"page":"2577-2584","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["Bone Morphogenetic Proteins Protect Pulmonary Microvascular Endothelial Cells From Apoptosis by Upregulating \u03b1-B-Crystallin"],"prefix":"10.1161","volume":"33","author":[{"given":"Mariana","family":"Ciumas","sequence":"first","affiliation":[{"name":"From the UMR_S 956; Univ Paris 06 (UPMC); Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), F-75013, Paris (M.C., M.E., O.P., S.M., F.D., K.M., S.N., F.S.); ICAN Institute for Cardiometabolism and Nutrition, Paris, France (M.E., O.P., S.M., F.D., S.N., F.S.); and UMR_S 999; INSERM; Univ Paris-Sud; LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France (N.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lanie","family":"Eyries","sequence":"additional","affiliation":[{"name":"From the UMR_S 956; Univ Paris 06 (UPMC); Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), F-75013, Paris (M.C., M.E., O.P., S.M., F.D., K.M., S.N., F.S.); ICAN Institute for Cardiometabolism and Nutrition, Paris, France (M.E., O.P., S.M., F.D., S.N., F.S.); and UMR_S 999; INSERM; Univ Paris-Sud; LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France (N.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odette","family":"Poirier","sequence":"additional","affiliation":[{"name":"From the UMR_S 956; Univ Paris 06 (UPMC); Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), F-75013, Paris (M.C., M.E., O.P., S.M., F.D., K.M., S.N., F.S.); ICAN Institute for Cardiometabolism and Nutrition, Paris, France (M.E., O.P., S.M., F.D., S.N., F.S.); and UMR_S 999; INSERM; Univ Paris-Sud; LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France (N.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Maugenre","sequence":"additional","affiliation":[{"name":"From the UMR_S 956; Univ Paris 06 (UPMC); Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), F-75013, Paris (M.C., M.E., O.P., S.M., F.D., K.M., S.N., F.S.); ICAN Institute for Cardiometabolism and Nutrition, Paris, France (M.E., O.P., S.M., F.D., S.N., F.S.); and UMR_S 999; INSERM; Univ Paris-Sud; LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France (N.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"France","family":"Dierick","sequence":"additional","affiliation":[{"name":"From the UMR_S 956; Univ Paris 06 (UPMC); Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), F-75013, Paris (M.C., M.E., O.P., S.M., F.D., K.M., S.N., F.S.); ICAN Institute for Cardiometabolism and Nutrition, Paris, France (M.E., O.P., S.M., F.D., S.N., F.S.); and UMR_S 999; INSERM; Univ Paris-Sud; LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France (N.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Gambaryan","sequence":"additional","affiliation":[{"name":"From the UMR_S 956; Univ Paris 06 (UPMC); Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), F-75013, Paris (M.C., M.E., O.P., S.M., F.D., K.M., S.N., F.S.); ICAN Institute for Cardiometabolism and Nutrition, Paris, France (M.E., O.P., S.M., F.D., S.N., F.S.); and UMR_S 999; INSERM; Univ Paris-Sud; LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France (N.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Montagne","sequence":"additional","affiliation":[{"name":"From the UMR_S 956; Univ Paris 06 (UPMC); Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), F-75013, Paris (M.C., M.E., O.P., S.M., F.D., K.M., S.N., F.S.); ICAN Institute for Cardiometabolism and Nutrition, Paris, France (M.E., O.P., S.M., F.D., S.N., F.S.); and UMR_S 999; INSERM; Univ Paris-Sud; LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France (N.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Nadaud","sequence":"additional","affiliation":[{"name":"From the UMR_S 956; Univ Paris 06 (UPMC); Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), F-75013, Paris (M.C., M.E., O.P., S.M., F.D., K.M., S.N., F.S.); ICAN Institute for Cardiometabolism and Nutrition, Paris, France (M.E., O.P., S.M., F.D., S.N., F.S.); and UMR_S 999; INSERM; Univ Paris-Sud; LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France (N.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florent","family":"Soubrier","sequence":"additional","affiliation":[{"name":"From the UMR_S 956; 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