{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T09:20:43Z","timestamp":1791537643271,"version":"4.3.4"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec>\n            <jats:title>Objective\u2014<\/jats:title>\n            <jats:p>\n              T cells, particularly CD8\n              <jats:sup>+<\/jats:sup>\n              T cells, are major participants in obesity-linked adipose tissue (AT) inflammation. We examined the mechanisms of CD8\n              <jats:sup>+<\/jats:sup>\n              T-cell accumulation and activation in AT and the role of CD11a, a \u03b22 integrin.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Approach and Results\u2014<\/jats:title>\n            <jats:p>\n              CD8\n              <jats:sup>+<\/jats:sup>\n              T cells in AT of obese mice showed activated phenotypes with increased proliferation and interferon-\u03b3 expression. In vitro, CD8\n              <jats:sup>+<\/jats:sup>\n              T cells from mouse AT displayed increased interferon-\u03b3 expression and proliferation to stimulation with interleukin-12 and interleukin-18, which were increased in obese AT. CD11a was upregulated in CD8\n              <jats:sup>+<\/jats:sup>\n              T cells in obese mice. Ablation of CD11a in obese mice dramatically reduced T-cell accumulation, activation, and proliferation in AT. Adoptive transfer showed that CD8\n              <jats:sup>+<\/jats:sup>\n              T cells from wild-type mice, but not from CD11a-deficient mice, infiltrated into AT of recipient obese wild-type mice. CD11a deficiency also reduced tumor necrosis factor-\u03b1\u2013producing and interleukin-12\u2013producing macrophages in AT and improved insulin resistance.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>\n              Combined action of cytokines in obese AT induces proliferative response of CD8\n              <jats:sup>+<\/jats:sup>\n              T cells locally, which, along with increased infiltration, contributes to CD8\n              <jats:sup>+<\/jats:sup>\n              T-cell accumulation and activation in AT. CD11a plays a crucial role in AT inflammation by participating in T-cell infiltration and activation.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/atvbaha.113.302077","type":"journal-article","created":{"date-parts":[[2013,10,25]],"date-time":"2013-10-25T08:30:36Z","timestamp":1382689836000},"page":"34-43","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":68,"title":["Essential Role of CD11a in CD8\n            <sup>+<\/sup>\n            T-Cell Accumulation and Activation in Adipose Tissue"],"prefix":"10.1161","volume":"34","author":[{"given":"Erlie","family":"Jiang","sequence":"first","affiliation":[{"name":"From the Departments of Medicine (E.J., X.D.P., D.Y., I.M.K., J.L.P., C.M.B., H.W.) and Pediatrics (C.W.S., C.M.B., H.W.), Baylor College of Medicine, Houston, TX; and Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart and Vascular Center, The Methodist Hospital, Houston, TX (C.M.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyuan Dai","family":"Perrard","sequence":"additional","affiliation":[{"name":"From the Departments of Medicine (E.J., X.D.P., D.Y., I.M.K., J.L.P., C.M.B., H.W.) and Pediatrics (C.W.S., C.M.B., H.W.), Baylor College of Medicine, Houston, TX; and Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart and Vascular Center, The Methodist Hospital, Houston, TX (C.M.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donglin","family":"Yang","sequence":"additional","affiliation":[{"name":"From the Departments of Medicine (E.J., X.D.P., D.Y., I.M.K., J.L.P., C.M.B., H.W.) and Pediatrics (C.W.S., C.M.B., H.W.), Baylor College of Medicine, Houston, TX; and Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart and Vascular Center, The Methodist Hospital, Houston, TX (C.M.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilvira M.","family":"Khan","sequence":"additional","affiliation":[{"name":"From the Departments of Medicine (E.J., X.D.P., D.Y., I.M.K., J.L.P., C.M.B., H.W.) and Pediatrics (C.W.S., C.M.B., H.W.), Baylor College of Medicine, Houston, TX; and Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart and Vascular Center, The Methodist Hospital, Houston, TX (C.M.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry L.","family":"Perrard","sequence":"additional","affiliation":[{"name":"From the Departments of Medicine (E.J., X.D.P., D.Y., I.M.K., J.L.P., C.M.B., H.W.) and Pediatrics (C.W.S., C.M.B., H.W.), Baylor College of Medicine, Houston, TX; and Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart and Vascular Center, The Methodist Hospital, Houston, TX (C.M.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Wayne","family":"Smith","sequence":"additional","affiliation":[{"name":"From the Departments of Medicine (E.J., X.D.P., D.Y., I.M.K., J.L.P., C.M.B., H.W.) and Pediatrics (C.W.S., C.M.B., H.W.), Baylor College of Medicine, Houston, TX; and Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart and Vascular Center, The Methodist Hospital, Houston, TX (C.M.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christie M.","family":"Ballantyne","sequence":"additional","affiliation":[{"name":"From the Departments of Medicine (E.J., X.D.P., D.Y., I.M.K., J.L.P., C.M.B., H.W.) and Pediatrics (C.W.S., C.M.B., H.W.), Baylor College of Medicine, Houston, TX; and Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart and Vascular Center, The Methodist Hospital, Houston, TX (C.M.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaizhu","family":"Wu","sequence":"additional","affiliation":[{"name":"From the Departments of Medicine (E.J., X.D.P., D.Y., I.M.K., J.L.P., C.M.B., H.W.) and Pediatrics (C.W.S., C.M.B., H.W.), Baylor College of Medicine, Houston, TX; and Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart and Vascular Center, The Methodist Hospital, Houston, TX (C.M.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05485"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2627"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.107.157685"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-1577"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200319246"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200319451"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.109.198044"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29881"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1964"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1000021"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.638379"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.108.177105"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2002"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2001"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.02.009"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.2337\/db12-1404"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.272.5258.60"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2156"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(2002010)32:10<2807::AID-IMMU2807>3.0.CO;2-0"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2006.11.008"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.05.029"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119293"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.1.297"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030002"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI43895"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.2337\/db09-1402"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2885"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.163.9.5029"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11132"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.2337\/db11-1065"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI61758"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.140.3.693"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00008.2006"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3071"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.2337\/db11-0860"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.108.823740"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2004.09.015"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.061655"}],"container-title":["Arteriosclerosis, Thrombosis, and Vascular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/ATVBAHA.113.302077","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T23:12:01Z","timestamp":1715555521000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/ATVBAHA.113.302077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1161\/ATVBAHA.113.302077"],"URL":"https:\/\/doi.org\/10.1161\/atvbaha.113.302077","relation":{},"ISSN":["1079-5642","1524-4636"],"issn-type":[{"value":"1079-5642","type":"print"},{"value":"1524-4636","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"2013-03-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-10-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-10-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}