{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:44:15Z","timestamp":1761561855435},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec>\n            <jats:title>Objective\u2014<\/jats:title>\n            <jats:p>To evaluate the impact of vitamin D and parathyroid hormone (PTH) on longitudinal changes in arterial stiffness.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Approach and Results\u2014<\/jats:title>\n            <jats:p>\n              Distensibility coefficient and Young\u2019s elastic modulus of the right common carotid artery were evaluated at baseline and after a mean (SD) of 9.4 (0.5) years in 2580 Multi-Ethnic Study of Atherosclerosis (MESA) participants. Cross-sectional and longitudinal associations were evaluated using multivariable linear regression and analysis of covariance. At baseline, participants were 60.1 (9.4) years old (54% female; 26% black, 20% Hispanic, 14% Chinese). Mean annualized 25(OH)D was &lt;20 ng\/dL in 816 participants, and PTH was &gt;65 pg\/dL in 285 participants. In cross-sectional analyses, low 25(OH)D (&lt;20 ng\/mL) was not associated with stiffer arteries after adjustment for cardiovascular disease risk factors (\n              <jats:italic>P<\/jats:italic>\n              &gt;0.4). PTH &gt;65 pg\/mL was associated with stiffer arteries after adjustment for cardiovascular disease risk factors, other than systolic blood pressure (distensibility coefficient: \u03b2=\u22122.4\u00d710\n              <jats:sup>\u22124<\/jats:sup>\n              mm Hg\n              <jats:sup>\u22121<\/jats:sup>\n              ,\n              <jats:italic>P<\/jats:italic>\n              =0.003; Young\u2019s elastic modulus: \u03b2=166 mm Hg,\n              <jats:italic>P<\/jats:italic>\n              =0.01); however, after adjustment for systolic blood pressure, these associations no longer were statistically significant. Longitudinal arterial stiffening was associated with older age (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001), higher systolic blood pressure (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.008), and use of antihypertensive medications (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.006), but not with 25(OH)D or PTH (both\n              <jats:italic>P<\/jats:italic>\n              &gt;0.1).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Carotid arterial stiffness is not associated with low 25(OH)D concentrations. Cross-sectional associations between arterial stiffness and high PTH were attenuated by systolic blood pressure. After nearly a decade of follow-up, neither baseline PTH nor 25(OH)D concentrations were associated with progression of carotid arterial stiffness.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/atvbaha.113.302605","type":"journal-article","created":{"date-parts":[[2014,4,4]],"date-time":"2014-04-04T04:06:49Z","timestamp":1396584409000},"page":"1102-1109","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["25-Hydroxyvitamin D and Parathyroid Hormone Levels Do Not Predict Changes in Carotid Arterial Stiffness"],"prefix":"10.1161","volume":"34","author":[{"given":"Adam D.","family":"Gepner","sequence":"first","affiliation":[{"name":"From the University of Wisconsin School of Medicine and Public Health, Madison, WI (A.D.G., C.E.K., J.H.S.); Northwestern University Feinberg School of Medicine, Chicago, IL (L.A.C., K.L.); University of Washington School of Public Health, Seattle (M.B., I.H.d.B., B.K., D.S.S., J.D.K.); and Department of Medicine, Geneva University Hospitals, Switzerland (M.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura A.","family":"Colangelo","sequence":"additional","affiliation":[{"name":"From the University of Wisconsin School of Medicine and Public Health, Madison, WI (A.D.G., C.E.K., J.H.S.); Northwestern University Feinberg School of Medicine, Chicago, IL (L.A.C., K.L.); University of Washington School of Public Health, Seattle (M.B., I.H.d.B., B.K., D.S.S., J.D.K.); and Department of Medicine, Geneva University Hospitals, Switzerland (M.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Blondon","sequence":"additional","affiliation":[{"name":"From the University of Wisconsin School of Medicine and Public Health, Madison, WI (A.D.G., C.E.K., J.H.S.); Northwestern University Feinberg School of Medicine, Chicago, IL (L.A.C., K.L.); University of Washington School of Public Health, Seattle (M.B., I.H.d.B., B.K., D.S.S., J.D.K.); and Department of Medicine, Geneva University Hospitals, Switzerland (M.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia E.","family":"Korcarz","sequence":"additional","affiliation":[{"name":"From the University of Wisconsin School of Medicine and Public Health, Madison, WI (A.D.G., C.E.K., J.H.S.); Northwestern University Feinberg School of Medicine, Chicago, IL (L.A.C., K.L.); University of Washington School of Public Health, Seattle (M.B., I.H.d.B., B.K., D.S.S., J.D.K.); and Department of Medicine, Geneva University Hospitals, Switzerland (M.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian H.","family":"de Boer","sequence":"additional","affiliation":[{"name":"From the University of Wisconsin School of Medicine and Public Health, Madison, WI (A.D.G., C.E.K., J.H.S.); Northwestern University Feinberg School of Medicine, Chicago, IL (L.A.C., K.L.); University of Washington School of Public Health, Seattle (M.B., I.H.d.B., B.K., D.S.S., J.D.K.); and Department of Medicine, Geneva University Hospitals, Switzerland (M.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan","family":"Kestenbaum","sequence":"additional","affiliation":[{"name":"From the University of Wisconsin School of Medicine and Public Health, Madison, WI (A.D.G., C.E.K., J.H.S.); Northwestern University Feinberg School of Medicine, Chicago, IL (L.A.C., K.L.); University of Washington School of Public Health, Seattle (M.B., I.H.d.B., B.K., D.S.S., J.D.K.); and Department of Medicine, Geneva University Hospitals, Switzerland (M.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S.","family":"Siscovick","sequence":"additional","affiliation":[{"name":"From the University of Wisconsin School of Medicine and Public Health, Madison, WI (A.D.G., C.E.K., J.H.S.); Northwestern University Feinberg School of Medicine, Chicago, IL (L.A.C., K.L.); University of Washington School of Public Health, Seattle (M.B., I.H.d.B., B.K., D.S.S., J.D.K.); and Department of Medicine, Geneva University Hospitals, Switzerland (M.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel D.","family":"Kaufman","sequence":"additional","affiliation":[{"name":"From the University of Wisconsin School of Medicine and Public Health, Madison, WI (A.D.G., C.E.K., J.H.S.); Northwestern University Feinberg School of Medicine, Chicago, IL (L.A.C., K.L.); University of Washington School of Public Health, Seattle (M.B., I.H.d.B., B.K., D.S.S., J.D.K.); and Department of Medicine, Geneva University Hospitals, Switzerland (M.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiang","family":"Liu","sequence":"additional","affiliation":[{"name":"From the University of Wisconsin School of Medicine and Public Health, Madison, WI (A.D.G., C.E.K., J.H.S.); Northwestern University Feinberg School of Medicine, Chicago, IL (L.A.C., K.L.); University of Washington School of Public Health, Seattle (M.B., I.H.d.B., B.K., D.S.S., J.D.K.); and Department of Medicine, Geneva University Hospitals, Switzerland (M.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James H.","family":"Stein","sequence":"additional","affiliation":[{"name":"From the University of Wisconsin School of Medicine and Public Health, Madison, WI (A.D.G., C.E.K., J.H.S.); Northwestern University Feinberg School of Medicine, Chicago, IL (L.A.C., K.L.); University of Washington School of Public Health, Seattle (M.B., I.H.d.B., B.K., D.S.S., J.D.K.); and Department of Medicine, Geneva University Hospitals, Switzerland (M.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.07.008"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.02.051"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.168.11.1174"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.04.042"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.107.706127"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.08.050"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.05.027"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.167.16.1730"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.03.069"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23738"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/79.5.820"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.5.1228"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.107.087288"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.108.808733"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01166-4"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000163130.39149.fe"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.105.555235"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1013749806227"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.111.626200"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.112.673533"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(97)00311-7"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2004.03.004"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.10.105"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.109.856070"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1584"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.11.075"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.1870230203"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH03-07-0423"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.5551\/jat.13128"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.05.010"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-156-9-201205010-00004"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036617"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.7228"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.6.1755"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008111157"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.113.301781"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-013-2281-1"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.673491"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12163"},{"key":"e_1_3_5_41_2","article-title":"Longitudinal Effects of a Decade of Aging on Carotid Artery Stiffness: The Multi-Ethnic Study of Atherosclerosis (MESA).","author":"Gepner AD","year":"2013","unstructured":"Gepner AD, Korcarz CE, Colangelo LA, Horn EK, Tattersall MC, Astor BC, Kaufman JD, Liu K, Stein JH. Longitudinal Effects of a Decade of Aging on Carotid Artery Stiffness: The Multi-Ethnic Study of Atherosclerosis (MESA). Stroke. 2013; Nov 19. 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