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These observations are supported by genetic analysis in humans implicating a lipid phosphate phosphatase as a novel risk factor for coronary artery disease. In this review, we summarize current understanding of LPA production, metabolism, and signaling as may be relevant for atherosclerotic and other vascular disease.<\/jats:p>","DOI":"10.1161\/atvbaha.113.302737","type":"journal-article","created":{"date-parts":[[2014,1,31]],"date-time":"2014-01-31T00:04:46Z","timestamp":1391126686000},"page":"479-486","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":62,"title":["Arguing the Case for the Autotaxin\u2013Lysophosphatidic Acid\u2013Lipid Phosphate Phosphatase 3-Signaling Nexus in the Development and Complications of Atherosclerosis"],"prefix":"10.1161","volume":"34","author":[{"given":"Susan S.","family":"Smyth","sequence":"first","affiliation":[{"name":"From the Veterans Affairs Medical Center, Cardiovascular Medicine Service, Lexington, KY (S.S.S., A.J.M.); and Division of Cardiovascular Medicine, Gill Heart Institute, University of Kentucky, Lexington, KY (S.S.S., P.M., F.Y., J.A.B., A.J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Mueller","sequence":"additional","affiliation":[{"name":"From the Veterans Affairs Medical Center, Cardiovascular Medicine Service, Lexington, KY (S.S.S., A.J.M.); and Division of Cardiovascular Medicine, Gill Heart Institute, University of Kentucky, Lexington, KY (S.S.S., P.M., F.Y., J.A.B., A.J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanmuyi","family":"Yang","sequence":"additional","affiliation":[{"name":"From the Veterans Affairs Medical Center, Cardiovascular Medicine Service, Lexington, KY (S.S.S., A.J.M.); and Division of Cardiovascular Medicine, Gill Heart Institute, University of Kentucky, Lexington, KY (S.S.S., P.M., F.Y., J.A.B., A.J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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