{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:41:21Z","timestamp":1790422881381,"version":"4.1.0"},"reference-count":46,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec>\n            <jats:title>Objective\u2014<\/jats:title>\n            <jats:p>\n              Pseudoxanthoma elasticum is an inherited metabolic disorder resulting from\n              <jats:italic>ABCC6<\/jats:italic>\n              gene mutations. It is characterized by progressive calcification and fragmentation of elastic fibers in the skin, retina, and the arterial wall. Despite calcium accumulation in the arteries of patients with pseudoxanthoma elasticum, functional consequences remain unknown. In the present study, we investigated arterial structure and function in\n              <jats:italic>Abcc6<\/jats:italic>\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              mice, a model of the human disease.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Approach and Results\u2014<\/jats:title>\n            <jats:p>\n              Arterial calcium accumulation was evaluated using alizarin red stain and atomic absorption spectrometry. Expression of genes involved in osteochondrogenic differentiation was measured by polymerase chain reaction. Elastic arterial properties were evaluated by carotid echotracking. Vascular reactivity was evaluated using wire and pressure myography and remodeling using histomorphometry. Arterial calcium accumulation was 1.5- to 2-fold higher in\n              <jats:italic>Abcc6<\/jats:italic>\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              than in wild-type mice. Calcium accumulated locally leading to punctuate pattern. Old\n              <jats:italic>Abcc6<\/jats:italic>\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              arteries expressed markers of both osteogenic (Runx2, osteopontin) and chondrogenic lineage (Sox9, type II collagen).\n              <jats:italic>Abcc6<\/jats:italic>\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              arteries displayed slight increase in arterial stiffness and vasoconstrictor tone in vitro tended to be higher in response to phenylephrine and thromboxane A2. Pressure-induced (myogenic) tone was significantly higher in\n              <jats:italic>Abcc6<\/jats:italic>\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              arteries than in wild type. Arterial blood pressure was not significantly changed in\n              <jats:italic>Abcc6<\/jats:italic>\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              , despite higher variability.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>\n              Scattered arterial calcium depositions are probably a result of osteochondrogenic transdifferentiation of vascular cells. Lower elasticity and increased myogenic tone without major changes in agonist-dependent contraction evidenced in aged\n              <jats:italic>Abcc6<\/jats:italic>\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              mice suggest a reduced control of local blood flow, which in turn may alter vascular homeostasis in the long term.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/atvbaha.113.302943","type":"journal-article","created":{"date-parts":[[2014,3,28]],"date-time":"2014-03-28T02:33:55Z","timestamp":1395974035000},"page":"1045-1056","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":32,"title":["Disseminated Arterial Calcification and Enhanced Myogenic Response Are Associated With Abcc6 Deficiency in a Mouse Model of Pseudoxanthoma Elasticum"],"prefix":"10.1161","volume":"34","author":[{"given":"Gilles","family":"Kauffenstein","sequence":"first","affiliation":[{"name":"From the CNRS UMR 6214, INSERM U1083, l\u2019UNAM (G.K., Y.L.C., E.V., L.G., B.T., G.L., D.H., L.M.) and Laboratoire de Pharmacologie-Toxicologie, l\u2019UNAM, Universit\u00e9 d\u2019Angers (Y.M.), University Hospital Angers, Angers, France; INSERM, U1116 (A.P., C.L., P.L.), Universit\u00e9 de Lorraine, Vandoeuvre-l\u00e8s-Nancy, France; Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI (O.L.S.); Molecular Ophthalmogenetics, Netherlands Institute for Neuroscience,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Pizard","sequence":"additional","affiliation":[{"name":"From the CNRS UMR 6214, INSERM U1083, l\u2019UNAM (G.K., Y.L.C., E.V., L.G., B.T., G.L., D.H., L.M.) and Laboratoire de Pharmacologie-Toxicologie, l\u2019UNAM, Universit\u00e9 d\u2019Angers (Y.M.), University Hospital Angers, Angers, France; INSERM, U1116 (A.P., C.L., P.L.), Universit\u00e9 de Lorraine, Vandoeuvre-l\u00e8s-Nancy, France; Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI (O.L.S.); Molecular Ophthalmogenetics, Netherlands Institute for Neuroscience,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Le Corre","sequence":"additional","affiliation":[{"name":"From the CNRS UMR 6214, INSERM U1083, l\u2019UNAM (G.K., Y.L.C., E.V., L.G., B.T., G.L., D.H., L.M.) and Laboratoire de Pharmacologie-Toxicologie, l\u2019UNAM, Universit\u00e9 d\u2019Angers (Y.M.), University Hospital Angers, Angers, France; INSERM, U1116 (A.P., C.L., P.L.), Universit\u00e9 de Lorraine, Vandoeuvre-l\u00e8s-Nancy, France; Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI (O.L.S.); Molecular Ophthalmogenetics, Netherlands Institute for Neuroscience,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Vessi\u00e8res","sequence":"additional","affiliation":[{"name":"From the CNRS UMR 6214, INSERM U1083, l\u2019UNAM (G.K., Y.L.C., E.V., L.G., B.T., G.L., D.H., L.M.) and Laboratoire de Pharmacologie-Toxicologie, l\u2019UNAM, Universit\u00e9 d\u2019Angers (Y.M.), University Hospital Angers, Angers, France; INSERM, U1116 (A.P., C.L., P.L.), Universit\u00e9 de Lorraine, Vandoeuvre-l\u00e8s-Nancy, France; Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI (O.L.S.); Molecular Ophthalmogenetics, Netherlands Institute for Neuroscience,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Grimaud","sequence":"additional","affiliation":[{"name":"From the CNRS UMR 6214, INSERM U1083, l\u2019UNAM (G.K., Y.L.C., E.V., L.G., B.T., G.L., D.H., L.M.) and Laboratoire de Pharmacologie-Toxicologie, l\u2019UNAM, Universit\u00e9 d\u2019Angers (Y.M.), University Hospital Angers, Angers, France; INSERM, U1116 (A.P., C.L., P.L.), Universit\u00e9 de Lorraine, Vandoeuvre-l\u00e8s-Nancy, France; Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI (O.L.S.); Molecular Ophthalmogenetics, Netherlands Institute for Neuroscience,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Toutain","sequence":"additional","affiliation":[{"name":"From the CNRS UMR 6214, INSERM U1083, l\u2019UNAM (G.K., Y.L.C., E.V., L.G., B.T., G.L., D.H., L.M.) and Laboratoire de Pharmacologie-Toxicologie, l\u2019UNAM, Universit\u00e9 d\u2019Angers (Y.M.), University Hospital Angers, Angers, France; INSERM, U1116 (A.P., C.L., P.L.), Universit\u00e9 de Lorraine, Vandoeuvre-l\u00e8s-Nancy, France; Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI (O.L.S.); Molecular Ophthalmogenetics, Netherlands Institute for Neuroscience,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Labat","sequence":"additional","affiliation":[{"name":"From the CNRS UMR 6214, INSERM U1083, l\u2019UNAM (G.K., Y.L.C., E.V., L.G., B.T., G.L., D.H., L.M.) and Laboratoire de Pharmacologie-Toxicologie, l\u2019UNAM, Universit\u00e9 d\u2019Angers (Y.M.), University Hospital Angers, Angers, France; INSERM, U1116 (A.P., C.L., P.L.), Universit\u00e9 de Lorraine, Vandoeuvre-l\u00e8s-Nancy, France; Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI (O.L.S.); Molecular Ophthalmogenetics, Netherlands Institute for Neuroscience,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Mauras","sequence":"additional","affiliation":[{"name":"From the CNRS UMR 6214, INSERM U1083, l\u2019UNAM (G.K., Y.L.C., E.V., L.G., B.T., G.L., D.H., L.M.) and Laboratoire de Pharmacologie-Toxicologie, l\u2019UNAM, Universit\u00e9 d\u2019Angers (Y.M.), University Hospital Angers, Angers, France; INSERM, U1116 (A.P., C.L., P.L.), Universit\u00e9 de Lorraine, Vandoeuvre-l\u00e8s-Nancy, France; Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI (O.L.S.); Molecular Ophthalmogenetics, Netherlands Institute for Neuroscience,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.G.","family":"Gorgels","sequence":"additional","affiliation":[{"name":"From the CNRS UMR 6214, INSERM U1083, l\u2019UNAM (G.K., Y.L.C., E.V., L.G., B.T., G.L., D.H., L.M.) and Laboratoire de Pharmacologie-Toxicologie, l\u2019UNAM, Universit\u00e9 d\u2019Angers (Y.M.), University Hospital Angers, Angers, France; INSERM, U1116 (A.P., C.L., P.L.), Universit\u00e9 de Lorraine, Vandoeuvre-l\u00e8s-Nancy, France; Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI (O.L.S.); Molecular Ophthalmogenetics, Netherlands Institute for Neuroscience,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.A.","family":"Bergen","sequence":"additional","affiliation":[{"name":"From the CNRS UMR 6214, INSERM U1083, l\u2019UNAM (G.K., Y.L.C., E.V., L.G., B.T., G.L., D.H., L.M.) and Laboratoire de Pharmacologie-Toxicologie, l\u2019UNAM, Universit\u00e9 d\u2019Angers (Y.M.), University Hospital Angers, Angers, France; INSERM, U1116 (A.P., C.L., P.L.), Universit\u00e9 de Lorraine, Vandoeuvre-l\u00e8s-Nancy, France; Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI (O.L.S.); Molecular Ophthalmogenetics, Netherlands Institute for Neuroscience,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Le Saux","sequence":"additional","affiliation":[{"name":"From the CNRS UMR 6214, INSERM U1083, l\u2019UNAM (G.K., Y.L.C., E.V., L.G., B.T., G.L., D.H., L.M.) and Laboratoire de Pharmacologie-Toxicologie, l\u2019UNAM, Universit\u00e9 d\u2019Angers (Y.M.), University Hospital Angers, Angers, France; INSERM, U1116 (A.P., C.L., P.L.), Universit\u00e9 de Lorraine, Vandoeuvre-l\u00e8s-Nancy, France; Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI (O.L.S.); Molecular Ophthalmogenetics, Netherlands Institute for Neuroscience,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Lacolley","sequence":"additional","affiliation":[{"name":"From the CNRS UMR 6214, INSERM U1083, l\u2019UNAM (G.K., Y.L.C., E.V., L.G., B.T., G.L., D.H., L.M.) and Laboratoire de Pharmacologie-Toxicologie, l\u2019UNAM, Universit\u00e9 d\u2019Angers (Y.M.), University Hospital Angers, Angers, France; INSERM, U1116 (A.P., C.L., P.L.), Universit\u00e9 de Lorraine, Vandoeuvre-l\u00e8s-Nancy, France; Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI (O.L.S.); Molecular Ophthalmogenetics, Netherlands Institute for Neuroscience,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Lefth\u00e9riotis","sequence":"additional","affiliation":[{"name":"From the CNRS UMR 6214, INSERM U1083, l\u2019UNAM (G.K., Y.L.C., E.V., L.G., B.T., G.L., D.H., L.M.) and Laboratoire de Pharmacologie-Toxicologie, l\u2019UNAM, Universit\u00e9 d\u2019Angers (Y.M.), University Hospital Angers, Angers, France; INSERM, U1116 (A.P., C.L., P.L.), Universit\u00e9 de Lorraine, Vandoeuvre-l\u00e8s-Nancy, France; Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI (O.L.S.); Molecular Ophthalmogenetics, Netherlands Institute for Neuroscience,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Henrion","sequence":"additional","affiliation":[{"name":"From the CNRS UMR 6214, INSERM U1083, l\u2019UNAM (G.K., Y.L.C., E.V., L.G., B.T., G.L., D.H., L.M.) and Laboratoire de Pharmacologie-Toxicologie, l\u2019UNAM, Universit\u00e9 d\u2019Angers (Y.M.), University Hospital Angers, Angers, France; INSERM, U1116 (A.P., C.L., P.L.), Universit\u00e9 de Lorraine, Vandoeuvre-l\u00e8s-Nancy, France; Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI (O.L.S.); Molecular Ophthalmogenetics, Netherlands Institute for Neuroscience,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Martin","sequence":"additional","affiliation":[{"name":"From the CNRS UMR 6214, INSERM U1083, l\u2019UNAM (G.K., Y.L.C., E.V., L.G., B.T., G.L., D.H., L.M.) and Laboratoire de Pharmacologie-Toxicologie, l\u2019UNAM, Universit\u00e9 d\u2019Angers (Y.M.), University Hospital Angers, Angers, France; INSERM, U1116 (A.P., C.L., P.L.), Universit\u00e9 de Lorraine, Vandoeuvre-l\u00e8s-Nancy, France; Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI (O.L.S.); Molecular Ophthalmogenetics, Netherlands Institute for Neuroscience,..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","first-page":"1","article-title":"Pseudoxanthoma elasticum.","volume":"6","author":"Neldner KH","year":"1988","unstructured":"Neldner KH. Pseudoxanthoma elasticum. Clin Dermatol. 1988;6:1\u2013159.","journal-title":"Clin Dermatol"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2008.00795.x"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.111.300194"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/000331979704800810"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000028420.27813.c0"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2004.030171"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/hy1101.096108"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.atv.0000067428.19031.28"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2004.06.004"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.653"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2011.04.041"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0755-4982(04)98652-6"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi183"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.18.8299-8310.2005"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.02.007"},{"key":"e_1_3_5_17_2","first-page":"S21","article-title":"Functional aspects of myogenic vascular control.","volume":"7","author":"Mellander S","year":"1989","unstructured":"Mellander S. Functional aspects of myogenic vascular control. J Hypertens Suppl. 1989;7:S21\u2013S30; discussion S31.","journal-title":"J Hypertens Suppl"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI17202"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/386078a0"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.84.2.166"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.111.247965"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2010.115"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63224-5"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.03.007"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0174-173X(87)80036-5"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M504166200"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0697-174"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.108.183053"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.04.149"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2010.68"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0912923"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2011.01.018"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2011.07.013"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2012.02.004"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.107.743161"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/76102"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1319582110"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00040.2010"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000131515.03336.f8"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvs152"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000149949.92854.45"},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn583"},{"key":"e_1_3_5_43_2","doi-asserted-by":"publisher","DOI":"10.1253\/jcj.63.806"},{"key":"e_1_3_5_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705367"},{"key":"e_1_3_5_45_2","doi-asserted-by":"publisher","DOI":"10.1124\/pr.113.008029"},{"key":"e_1_3_5_46_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068700"},{"key":"e_1_3_5_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2011.11.020"}],"updated-by":[{"DOI":"10.1161\/atv.0000000000000017","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000}}],"container-title":["Arteriosclerosis, Thrombosis, and Vascular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/ATVBAHA.113.302943","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:47:58Z","timestamp":1715554078000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/ATVBAHA.113.302943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1161\/ATVBAHA.113.302943"],"URL":"https:\/\/doi.org\/10.1161\/atvbaha.113.302943","relation":{"correction":[{"id-type":"doi","id":"10.1161\/ATV.0000000000000017","asserted-by":"object"}]},"ISSN":["1079-5642","1524-4636"],"issn-type":[{"value":"1079-5642","type":"print"},{"value":"1524-4636","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"2013-07-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-03-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-03-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}