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One promising target is the platelet collagen receptor glycoprotein VI. Blockade or antibody-mediated depletion of this receptor in circulating platelets is beneficial in experimental models of thrombosis and thrombo-inflammatory diseases, such as stroke, without impairing hemostasis. In this review, we summarize the importance of glycoprotein VI and (hem)immunoreceptor tyrosine-based activation motif signaling in hemostasis, thrombosis, and thrombo-inflammatory processes and discuss the targeting strategies currently under development for inhibiting glycoprotein VI and its signaling.<\/jats:p>","DOI":"10.1161\/atvbaha.114.303408","type":"journal-article","created":{"date-parts":[[2014,6,13]],"date-time":"2014-06-13T07:01:52Z","timestamp":1402642912000},"page":"1615-1620","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":56,"title":["Targeting Glycoprotein VI and the Immunoreceptor Tyrosine-Based Activation Motif Signaling Pathway"],"prefix":"10.1161","volume":"34","author":[{"given":"David","family":"Stegner","sequence":"first","affiliation":[{"name":"From the Department of Experimental Biomedicine, University Hospital W\u00fcrzburg and Rudolf Virchow Center for Experimental Biomedicine, University of 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