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The latter dual pathway blockade strategy is one of the greatest advances in the field of cardiovascular medicine. In addition to P2Y\n                    <jats:sub>12<\/jats:sub>\n                    , the platelet thrombin receptor, protease activated receptor-1, has also been recently targeted for inhibition. Blockade of protease activated receptor-1 has been associated with reduced thrombotic event occurrence when added to a strategy using P2Y\n                    <jats:sub>12<\/jats:sub>\n                    and cyclooxygenase-1 inhibition. At this time, the relative contributions of these G-protein\u2013coupled receptor signaling pathways to in vivo thrombosis remain incompletely defined. The observation of treatment failure in \u224810% of high-risk patients treated with aspirin and potent P2Y\n                    <jats:sub>12<\/jats:sub>\n                    inhibitors provides the rationale for targeting novel pathways mediating platelet function. Targeting intracellular signaling downstream from G-protein\u2013coupled receptor receptors with phosphotidylionisitol 3-kinase and Gq inhibitors are among the novel strategies under investigation to prevent arterial ischemic event occurrence. Greater understanding of the mechanisms of G-protein\u2013coupled receptor\u2013mediated signaling may allow the tailoring of antiplatelet therapy.\n                  <\/jats:p>","DOI":"10.1161\/atvbaha.114.303412","type":"journal-article","created":{"date-parts":[[2015,1,29]],"date-time":"2015-01-29T22:29:05Z","timestamp":1422570545000},"page":"500-512","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":83,"title":["G-Protein\u2013Coupled Receptors Signaling Pathways in New Antiplatelet Drug Development"],"prefix":"10.1161","volume":"35","author":[{"given":"Paul A.","family":"Gurbel","sequence":"first","affiliation":[{"name":"From the Sinai Center for Thrombosis Research, Sinai Hospital of Baltimore, MD (P.A.G., U.S.T.); and Center for Hemostasis and Thrombosis Research, Tufts Medical Center, Boston, MA (A.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athan","family":"Kuliopulos","sequence":"additional","affiliation":[{"name":"From the Sinai Center for Thrombosis Research, Sinai Hospital of Baltimore, MD (P.A.G., U.S.T.); 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