{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:08:43Z","timestamp":1791220123700,"version":"4.1.0"},"reference-count":56,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec>\n            <jats:title>Objective\u2014<\/jats:title>\n            <jats:p>Abdominal aortic aneurysm (AAA) is widespread among elderly people and results in progressive expansion and rupture of the aorta with high mortality. Macrophages, which are the main population observed within the site of aneurysm, are thought to derive from circulating monocytes although no direct evidence has been provided to date. In this study, we were particularly interested in understanding the trafficking behavior of monocyte subsets in AAA and their role in disease pathogenesis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Approach and Results\u2014<\/jats:title>\n            <jats:p>\n              Using bone marrow transplantation in\n              <jats:italic>Apoe<\/jats:italic>\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              mice, we showed that circulating monocytes give rise to abdominal aortic macrophages in hypercholesterolemic mice submitted to angiotensin II (AngII). Detailed monitoring of monocyte compartmentalization revealed that lymphocyte antigen 6C\n              <jats:sup>high<\/jats:sup>\n              and lymphocyte antigen 6C\n              <jats:sup>low<\/jats:sup>\n              monocytes transiently increase in blood early after AngII infusion and differentially infiltrate the abdominal aorta. The splenic reservoir accounted for the mobilization of the 2 monocyte subsets after 3 days of AngII infusion. Spleen removal or lymphocyte deficiency in\n              <jats:italic>Apoe<\/jats:italic>\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              <jats:italic>Rag2<\/jats:italic>\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              mice similarly impaired early monocyte increase in blood in response to AngII and protected against AAA development, independently of blood pressure. Reconstitution of\n              <jats:italic>Apoe<\/jats:italic>\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              <jats:italic>Rag2<\/jats:italic>\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              mice with total splenocytes but not with B-cell\u2013depleted splenocytes restored monocyte mobilization in response to AngII and enhanced susceptibility to AAA.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>\n              Taken together, the data show that lymphocyte antigen 6C\n              <jats:sup>high<\/jats:sup>\n              and lymphocyte antigen 6C\n              <jats:sup>low<\/jats:sup>\n              monocytes are mobilized from the spleen in response to AngII. Intriguingly, the process is dependent on the presence of B cells and significantly contributes to the development of AAA and the occurrence of aortic rupture.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/atvbaha.114.304389","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T11:20:17Z","timestamp":1418988017000},"page":"378-388","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":108,"title":["Angiotensin II Mobilizes Spleen Monocytes to Promote the Development of Abdominal Aortic Aneurysm in\n            <i>Apoe<\/i>\n            <sup>\u2212\/\u2212<\/sup>\n            Mice"],"prefix":"10.1161","volume":"35","author":[{"given":"Safa","family":"Mellak","sequence":"first","affiliation":[{"name":"From the INSERM Unit UMR-S 970, Paris Cardiovascular Research Center (PARCC), Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Paris, France (S.M., H.A.-O., B.E., X.L., M.P., A.T., Z.M., S.P.); R\u00e9animation M\u00e9dicale, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Saint-Antoine, Universit\u00e9 Pierre-et-Marie Curie, Universit\u00e9 Pierre-et-Marie Curie, Paris, France (H.A.-O.); Department of Immunology, Duke University Medical Center, Durham, NC (T.F.T.); and Department of Medicine, University of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hafid","family":"Ait-Oufella","sequence":"additional","affiliation":[{"name":"From the INSERM Unit UMR-S 970, Paris Cardiovascular Research Center (PARCC), Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Paris, France (S.M., H.A.-O., B.E., X.L., M.P., A.T., Z.M., S.P.); R\u00e9animation M\u00e9dicale, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Saint-Antoine, Universit\u00e9 Pierre-et-Marie Curie, Universit\u00e9 Pierre-et-Marie Curie, Paris, France (H.A.-O.); Department of Immunology, Duke University Medical Center, Durham, NC (T.F.T.); and Department of Medicine, University of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Esposito","sequence":"additional","affiliation":[{"name":"From the INSERM Unit UMR-S 970, Paris Cardiovascular Research Center (PARCC), Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Paris, France (S.M., H.A.-O., B.E., X.L., M.P., A.T., Z.M., S.P.); R\u00e9animation M\u00e9dicale, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Saint-Antoine, Universit\u00e9 Pierre-et-Marie Curie, Universit\u00e9 Pierre-et-Marie Curie, Paris, France (H.A.-O.); Department of Immunology, Duke University Medical Center, Durham, NC (T.F.T.); and Department of Medicine, University of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Loyer","sequence":"additional","affiliation":[{"name":"From the INSERM Unit UMR-S 970, Paris Cardiovascular Research Center (PARCC), Universit\u00e9 Paris Descartes, Sorbonne Paris 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