{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:05:05Z","timestamp":1791295505295,"version":"4.1.0"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec>\n            <jats:title>Objective\u2014<\/jats:title>\n            <jats:p>Low-density lipoprotein receptor\u2013related protein 1 (LRP1), a multifunctional protein involved in endocytosis and cell signaling pathways, leads to several vascular pathologies when deleted in vascular smooth muscle cells (SMCs). The purpose of this study was to determine whether LRP1 deletion in SMCs influenced angiotensin II\u2013induced arterial pathologies.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Approach and Results\u2014<\/jats:title>\n            <jats:p>\n              LRP1 protein abundance was equivalent in selected arterial regions, but SMC-specific LRP1 depletion had no effect on abdominal and ascending aortic diameters in young mice. To determine the effects of LRP1 deficiency on angiotensin II vascular responses, SMC-specific LRP1 (smLRP1\n              <jats:sup>+\/+<\/jats:sup>\n              ) and smLRP1-deficient (smLRP1\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              ) mice were infused with saline, angiotensin II, or norepinephrine. Several smLRP\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              mice died of superior mesenteric arterial (SMA) rupture during angiotensin II infusion. In surviving mice, angiotensin II profoundly augmented SMA dilation in smLRP1\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              mice. SMA dilation was blood pressure dependent as demonstrated by a similar response during norepinephrine infusion. SMA dilation was also associated with profound macrophage accumulation, but minimal elastin fragmentation. Angiotensin II infusion led to no significant differences in abdominal aorta diameters between smLRP1\n              <jats:sup>+\/+<\/jats:sup>\n              and smLRP1\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              mice. In contrast, ascending aortic dilation was exacerbated markedly in angiotensin II\u2013infused smLRP1\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              mice, but norepinephrine had no significant effect on either aortic region. Ascending aortas of smLRP1\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              mice infused with angiotensin II had minimal macrophage accumulation but significantly increased elastin fragmentation and mRNA abundance of several LRP1 ligands including MMP-2 (matrix metalloproteinase-2) and uPA (urokinase plasminogen activator).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>\n              smLRP1 deficiency had no effect on angiotensin II\u2013induced abdominal aortic aneurysm formation. Conversely, angiotensin II infusion in smLRP1\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              mice exacerbated SMA and ascending aorta dilation. Dilation in these 2 regions had differential association with blood pressure and divergent pathological characteristics.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/atvbaha.114.304683","type":"journal-article","created":{"date-parts":[[2014,11,14]],"date-time":"2014-11-14T07:09:27Z","timestamp":1415948967000},"page":"155-162","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":63,"title":["Smooth Muscle Cell Deletion of Low-Density Lipoprotein Receptor\u2013Related Protein 1 Augments Angiotensin II\u2013Induced Superior Mesenteric Arterial and Ascending Aortic Aneurysms"],"prefix":"10.1161","volume":"35","author":[{"given":"Frank M.","family":"Davis","sequence":"first","affiliation":[{"name":"From the Saha Cardiovascular Research Center (F.M.D., D.L.R., A.B., D.A.H., C.M.H., B.K.F., A.D.), Department of Pediatrics (B.K.F.), Department of Pharmacology and Nutritional Sciences (L.A.C.), University of Kentucky, Lexington; and Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore (D.K.S., S.C.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra L.","family":"Rateri","sequence":"additional","affiliation":[{"name":"From the Saha Cardiovascular Research Center (F.M.D., D.L.R., A.B., D.A.H., C.M.H., B.K.F., A.D.), Department of Pediatrics (B.K.F.), Department of Pharmacology and Nutritional Sciences (L.A.C.), University of Kentucky, Lexington; and Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore (D.K.S., S.C.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anju","family":"Balakrishnan","sequence":"additional","affiliation":[{"name":"From the Saha Cardiovascular Research Center (F.M.D., D.L.R., A.B., D.A.H., C.M.H., B.K.F., A.D.), Department of Pediatrics (B.K.F.), Department of Pharmacology and Nutritional Sciences (L.A.C.), University of Kentucky, Lexington; and Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore (D.K.S., S.C.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah A.","family":"Howatt","sequence":"additional","affiliation":[{"name":"From the Saha Cardiovascular Research Center (F.M.D., D.L.R., A.B., D.A.H., C.M.H., B.K.F., A.D.), Department of Pediatrics (B.K.F.), Department of Pharmacology and Nutritional Sciences (L.A.C.), University of Kentucky, Lexington; and Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore (D.K.S., S.C.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dudley K.","family":"Strickland","sequence":"additional","affiliation":[{"name":"From the Saha Cardiovascular Research Center (F.M.D., D.L.R., A.B., D.A.H., C.M.H., B.K.F., A.D.), Department of Pediatrics (B.K.F.), Department of Pharmacology and Nutritional Sciences (L.A.C.), University of Kentucky, Lexington; and Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore (D.K.S., S.C.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selen C.","family":"Muratoglu","sequence":"additional","affiliation":[{"name":"From the Saha Cardiovascular Research Center (F.M.D., D.L.R., A.B., D.A.H., C.M.H., B.K.F., A.D.), Department of Pediatrics (B.K.F.), Department of Pharmacology and Nutritional Sciences (L.A.C.), University of Kentucky, Lexington; and Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore (D.K.S., S.C.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"Haggerty","sequence":"additional","affiliation":[{"name":"From the Saha Cardiovascular Research Center (F.M.D., D.L.R., A.B., D.A.H., C.M.H., B.K.F., A.D.), Department of Pediatrics (B.K.F.), Department of Pharmacology and Nutritional Sciences (L.A.C.), University of Kentucky, Lexington; and Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore (D.K.S., S.C.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon K.","family":"Fornwalt","sequence":"additional","affiliation":[{"name":"From the Saha Cardiovascular Research Center (F.M.D., D.L.R., A.B., D.A.H., C.M.H., B.K.F., A.D.), Department of Pediatrics (B.K.F.), Department of Pharmacology and Nutritional Sciences (L.A.C.), University of Kentucky, Lexington; and Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore (D.K.S., S.C.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa A.","family":"Cassis","sequence":"additional","affiliation":[{"name":"From the Saha Cardiovascular Research Center (F.M.D., D.L.R., A.B., D.A.H., C.M.H., B.K.F., A.D.), Department of Pediatrics (B.K.F.), Department of Pharmacology and Nutritional Sciences (L.A.C.), University of Kentucky, Lexington; and Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore (D.K.S., S.C.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Daugherty","sequence":"additional","affiliation":[{"name":"From the Saha Cardiovascular Research Center (F.M.D., D.L.R., A.B., D.A.H., C.M.H., B.K.F., A.D.), Department of Pediatrics (B.K.F.), Department of Pharmacology and Nutritional Sciences (L.A.C.), University of Kentucky, Lexington; and Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore (D.K.S., S.C.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200113992"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.113.301924"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90511-A"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1082095"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.atv.0000249641.96896.e6"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.0000260204.40510.aa"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.109.194357"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028846"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.113.301893"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0082026"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2011.10.002"},{"key":"e_1_3_4_13_2","article-title":"Association of rs1466535 LRP1 but not rs3019885 SLC30A8 and rs6674171 TDRD10 gene polymorphisms with abdominal aortic aneurysm in Italian patients.","author":"Galora S","year":"2014","unstructured":"Galora S, Saracini C, Pratesi G, Sticchi E, Pulli R, Pratesi C, Abbate R, Giusti B. Association of rs1466535 LRP1 but not rs3019885 SLC30A8 and rs6674171 TDRD10 gene polymorphisms with abdominal aortic aneurysm in Italian patients. J Vasc Surg. 2014;Jan 11. pii:S0741\u20135214(13)01998\u20138.","journal-title":"J Vasc Surg"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2013.08.006"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-9-25"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI7818"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.3.448"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20090372"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn043"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117809"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.111.239897"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.12.152"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.atv.0000092913.60428.e6"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00028.2009"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.109.212837"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2014.05.014"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.atv.0000254680.71485.92"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048462"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061849"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051483"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.110.222844"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.atv.0000085631.76095.64"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI38308"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006922"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109926"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.0000061571.49375.e1"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.atv.0000216119.79008.ac"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.111.234997"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2011.04.002"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1124287"}],"container-title":["Arteriosclerosis, Thrombosis, and Vascular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/ATVBAHA.114.304683","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T23:15:00Z","timestamp":1715555700000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/ATVBAHA.114.304683"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1161\/ATVBAHA.114.304683"],"URL":"https:\/\/doi.org\/10.1161\/atvbaha.114.304683","relation":{},"ISSN":["1079-5642","1524-4636"],"issn-type":[{"value":"1079-5642","type":"print"},{"value":"1524-4636","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"2014-09-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-11-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-11-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}