{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:15:38Z","timestamp":1790507738623,"version":"4.1.0"},"reference-count":60,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec>\n            <jats:title>Objective\u2014<\/jats:title>\n            <jats:p>Syndecan-1 (Sdc-1) is a member of a family of cell surface proteoglycans, which has been reported to participate in the regulation of events relevant to tissue repair and chronic injury responses, including cell\u2013substrate interactions, matrix remodeling, and cell migration. In this study, we report the functional significance of Sdc-1 in polarized macrophage populations and its role in adhesion and motility events relevant to resolution of the inflammatory program.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Approach and Results\u2014<\/jats:title>\n            <jats:p>\n              Macrophage Sdc-1 expression is associated with differentiated M2 macrophages with high intrinsic motility, and Sdc-1 deficiency is characterized by impaired migration and enhanced adhesion. Leukocyte infiltration and emigration were examined in a thioglycollate-induced model of peritonitis in Sdc-1\n              <jats:sup>+\/+<\/jats:sup>\n              and Sdc-1\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              mice. Although the infiltration of inflammatory cells was similar in both cohorts, a significant delay in the lymphatic clearance of Sdc-1\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              macrophages was observed. Moreover, we observed enhanced inflammation and greater burden of atherosclerotic plaques in ApoE\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              Sdc-1\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              mice maintained on a Western diet.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>\n              These results demonstrate that defective motility in Sdc-1\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              macrophages promotes a persistent inflammatory state with relevance to the pathogenesis of atherosclerosis.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/atvbaha.114.304720","type":"journal-article","created":{"date-parts":[[2014,12,31]],"date-time":"2014-12-31T05:39:52Z","timestamp":1420004392000},"page":"332-340","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":54,"title":["Syndecan-1 Modulates the Motility and Resolution Responses of Macrophages"],"prefix":"10.1161","volume":"35","author":[{"given":"Julianty","family":"Angsana","sequence":"first","affiliation":[{"name":"From the Department of Bioengineering, Georgia Institute of Technology, Atlanta (J.A.); Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (J.C., L.L., C.A.H., E.L.C.); Department of Surgery, Emory University, Atlanta, GA (S.S., J.X., J.W.); and Wyss Institute of Biologically Inspired Engineering, Harvard University, Boston, MA 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(E.L.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiantao","family":"Xiao","sequence":"additional","affiliation":[{"name":"From the Department of Bioengineering, Georgia Institute of Technology, Atlanta (J.A.); Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (J.C., L.L., C.A.H., E.L.C.); Department of Surgery, Emory University, Atlanta, GA (S.S., J.X., J.W.); and Wyss Institute of Biologically Inspired Engineering, Harvard University, Boston, MA (E.L.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wen","sequence":"additional","affiliation":[{"name":"From the Department of Bioengineering, Georgia Institute of Technology, Atlanta (J.A.); Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (J.C., L.L., C.A.H., E.L.C.); Department of Surgery, Emory University, Atlanta, GA (S.S., J.X., J.W.); and Wyss Institute of Biologically Inspired Engineering, Harvard University, Boston, MA 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