{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T12:18:21Z","timestamp":1779193101619,"version":"3.51.4"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec>\n            <jats:title>Objective\u2014<\/jats:title>\n            <jats:p>Neointima formation is associated with stenosis and subsequent thrombosis in arteriovenous grafts (AVGs). A role of integrin \u03b23 in the neointima formation of AVGs remains poorly understood.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Approach and Results\u2014<\/jats:title>\n            <jats:p>\n              In integrin \u03b23\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              mice, we found significantly accelerated occlusion of AVGs compared with the wild-type mice. This is caused by the development of neointima and lack of endothelial regeneration. The latter is a direct consequence of impaired functions of circulating angiogenic cells (CACs) and platelets in integrin \u03b23\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              mice. Evidence suggests the involvement of platelet regulating CAC homing to and differentiation at graft sites via transforming growth factor-\u03b21 and Notch signaling pathway. First, CACs deficient of integrin \u03b23 impaired adhesion activity toward exposed subendothelium. Second, platelets from integrin \u03b23\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              mice failed to sufficiently stimulate CACs to differentiate into mature endothelial cells. Finally, we found that transforming growth factor-\u03b21 level was increased in platelets from integrin \u03b23\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              mice and resulted in enhanced Notch1 activation in CACs in AVGs. These results demonstrate that integrin \u03b23 is critical for endothelial cell homing and differentiation. The increased transforming growth factor-\u03b21 and Notch1 signaling mediates integrin \u03b23\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              -induced AVG occlusion. This accelerated occlusion of AVGs was reversed in integrin \u03b23\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              mice transplanted with the bone marrow from wild-type mice.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Our results suggest that boosting integrin \u03b23 function in the endothelial cells and platelets could prevent neointima and thrombosis in AVGs.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/atvbaha.114.305089","type":"journal-article","created":{"date-parts":[[2015,1,23]],"date-time":"2015-01-23T06:33:29Z","timestamp":1421994809000},"page":"607-615","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Impaired Integrin \u03b23 Delays Endothelial Cell Regeneration and Contributes to Arteriovenous Graft Failure in Mice"],"prefix":"10.1161","volume":"35","author":[{"given":"Ming","family":"Liang","sequence":"first","affiliation":[{"name":"From the Department of Nephrology, Guangzhou First People\u2019s Hospital, Guangzhou Medical University, Guangzhou, China (M.L.); Department of Cell Biology, Third Military Medical University, Chongqing, China (Y.W.); Puget Sound Blood Research Institute, Hematology Division, Department of Medicine, University of Washington, Seattle (J.-F.D.); Beijing Anzhen Hospital Affiliated to the Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, China (J.D.); and..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Wang","sequence":"additional","affiliation":[{"name":"From the Department of Nephrology, Guangzhou First People\u2019s Hospital, Guangzhou Medical University, Guangzhou, China (M.L.); Department of Cell Biology, Third Military Medical University, Chongqing, China (Y.W.); Puget Sound Blood Research Institute, Hematology Division, Department of Medicine, University of Washington, Seattle (J.-F.D.); Beijing Anzhen Hospital Affiliated to the Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, China (J.D.); and..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anlin","family":"Liang","sequence":"additional","affiliation":[{"name":"From the Department of Nephrology, Guangzhou First People\u2019s Hospital, Guangzhou Medical University, Guangzhou, China (M.L.); Department of Cell Biology, Third Military Medical University, Chongqing, China (Y.W.); Puget Sound Blood Research Institute, Hematology Division, Department of Medicine, University of Washington, Seattle (J.-F.D.); Beijing Anzhen Hospital Affiliated to the Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, China (J.D.); and..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Fei","family":"Dong","sequence":"additional","affiliation":[{"name":"From the Department of Nephrology, Guangzhou First People\u2019s Hospital, Guangzhou Medical University, Guangzhou, China (M.L.); Department of Cell Biology, Third Military Medical University, Chongqing, China (Y.W.); Puget Sound Blood Research Institute, Hematology Division, Department of Medicine, University of Washington, Seattle (J.-F.D.); Beijing Anzhen Hospital Affiliated to the Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, China (J.D.); and..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Du","sequence":"additional","affiliation":[{"name":"From the Department of Nephrology, Guangzhou First People\u2019s Hospital, Guangzhou Medical University, Guangzhou, China (M.L.); Department of Cell Biology, Third Military Medical University, Chongqing, China (Y.W.); Puget Sound Blood Research Institute, Hematology Division, Department of Medicine, University of Washington, Seattle (J.-F.D.); Beijing Anzhen Hospital Affiliated to the Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, China (J.D.); and..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jizhong","family":"Cheng","sequence":"additional","affiliation":[{"name":"From the Department of Nephrology, Guangzhou First People\u2019s Hospital, Guangzhou Medical University, Guangzhou, China (M.L.); Department of Cell Biology, Third Military Medical University, Chongqing, China (Y.W.); Puget Sound Blood Research Institute, Hematology Division, Department of Medicine, University of Washington, Seattle (J.-F.D.); Beijing Anzhen Hospital Affiliated to the Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, China (J.D.); and..."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3182009701"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2006.04.029"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0800887"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH07-02-0147"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.539221"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.2660"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1165"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000097864.24725.60"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000201285.87524.9e"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH06-05-0250"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20051772"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600069"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.3.221"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3006927"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000105722.96112.67"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5302.964"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2007.11.004"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000018166.84319.55"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000083812.30141.74"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200802179"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-6265fje"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI14047"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.246025"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI5487"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-02-205930"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000222982.55731.f1"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI27196"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.132.3.7679986"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.09.032"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.292649"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.459750"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2007.02.012"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.553917"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.754978"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013050490"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02733"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000121733.68724.FF"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/35051599"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezu098"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00384.2009"},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.01.240"}],"container-title":["Arteriosclerosis, Thrombosis, and Vascular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/ATVBAHA.114.305089","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T23:02:32Z","timestamp":1715554952000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/ATVBAHA.114.305089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1161\/ATVBAHA.114.305089"],"URL":"https:\/\/doi.org\/10.1161\/atvbaha.114.305089","relation":{},"ISSN":["1079-5642","1524-4636"],"issn-type":[{"value":"1079-5642","type":"print"},{"value":"1524-4636","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"2014-05-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-12-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-01-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}