{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:16:15Z","timestamp":1790514975571,"version":"4.1.0"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec>\n            <jats:title>Objective\u2014<\/jats:title>\n            <jats:p>To determine the role of regulatory B cell\u2013derived interleukin (IL)-10 in atherosclerosis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Approach and Results\u2014<\/jats:title>\n            <jats:p>\n              We created chimeric\n              <jats:italic>Ldlr<\/jats:italic>\n              <jats:sup>\n                <jats:italic>\u2212\/\u2212<\/jats:italic>\n              <\/jats:sup>\n              mice with a B cell\u2013specific deficiency in IL-10, and confirmed that purified B cells stimulated with lipopolysaccharide failed to produce IL-10 compared with control\n              <jats:italic>Ldlr<\/jats:italic>\n              <jats:sup>\n                <jats:italic>\u2212\/\u2212<\/jats:italic>\n              <\/jats:sup>\n              chimeras. Mice lacking B-cell IL-10 demonstrated enhanced splenic B-cell numbers but no major differences in B-cell subsets, T cell or monocyte distribution, and unchanged body weights or serum cholesterol levels compared with control mice. After 8 weeks on high-fat diet, there were no differences in aortic root or aortic arch atherosclerosis. In addition to plaque size, plaque composition (macrophages, T cells, smooth muscle cells, and collagen) was similar between groups.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>In contrast to its prominent regulatory role in many immune-mediated diseases and its proposed modulatory role in atherosclerosis, B cell\u2013derived IL-10 does not alter atherosclerosis in mice.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/atvbaha.115.305568","type":"journal-article","created":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T03:55:56Z","timestamp":1434686156000},"page":"1770-1773","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":58,"title":["Regulatory B Cell\u2013Specific Interleukin-10 Is Dispensable for Atherosclerosis Development in Mice"],"prefix":"10.1161","volume":"35","author":[{"given":"Andrew P.","family":"Sage","sequence":"first","affiliation":[{"name":"From the Division of Cardiovascular Medicine, Department of Medicine, University of Cambridge, Cambridge, United Kingdom (A.P.S, M.S, L.L.B., A.J.F., L.M.M., Z.M.); and Institut National de la Sante et de la Recherche Medicale, Paris, France (Z.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meritxell","family":"Nus","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Medicine, Department of Medicine, University of Cambridge, Cambridge, United Kingdom (A.P.S, M.S, L.L.B., A.J.F., L.M.M., Z.M.); and Institut National de la Sante et de la Recherche Medicale, Paris, France (Z.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren L.","family":"Baker","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Medicine, Department of Medicine, University of Cambridge, Cambridge, United Kingdom (A.P.S, M.S, L.L.B., A.J.F., L.M.M., Z.M.); and Institut National de la Sante et de la Recherche Medicale, Paris, France (Z.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison J.","family":"Finigan","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Medicine, Department of Medicine, University of Cambridge, Cambridge, United Kingdom (A.P.S, M.S, L.L.B., A.J.F., L.M.M., Z.M.); and Institut National de la Sante et de la Recherche Medicale, Paris, France (Z.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leanne M.","family":"Masters","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Medicine, Department of Medicine, University of Cambridge, Cambridge, United Kingdom (A.P.S, M.S, L.L.B., A.J.F., L.M.M., Z.M.); and Institut National de la Sante et de la Recherche Medicale, Paris, France (Z.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziad","family":"Mallat","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Medicine, Department of Medicine, University of Cambridge, Cambridge, United Kingdom (A.P.S, M.S, L.L.B., A.J.F., L.M.M., Z.M.); and Institut National de la Sante et de la Recherche Medicale, Paris, France (Z.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht301"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.179739"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-013-1289-1"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.302761"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401329"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni833"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021293"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3680"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1324052111"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI7272"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000039169.47943.EE"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20100155"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.111.244731"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1000033"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.303569"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH13-10-0865"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.0000018941.10726.fa"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.85.8.e17"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000089083.61317.A1"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000134378.86443.cd"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.256438"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.006381"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp300"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.248542"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.868158"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12979"}],"container-title":["Arteriosclerosis, Thrombosis, and Vascular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/ATVBAHA.115.305568","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:45:28Z","timestamp":1715553928000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/ATVBAHA.115.305568"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":26,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1161\/ATVBAHA.115.305568"],"URL":"https:\/\/doi.org\/10.1161\/atvbaha.115.305568","relation":{},"ISSN":["1079-5642","1524-4636"],"issn-type":[{"value":"1079-5642","type":"print"},{"value":"1524-4636","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"2015-03-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-06-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-06-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}