{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T17:13:39Z","timestamp":1789665219384,"version":"4.0.1"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec>\n            <jats:title>Objective\u2014<\/jats:title>\n            <jats:p>\n              Marfan syndrome (MFS) is a connective tissue disorder caused by mutations in the fibrillin-1 gene. Patients with MFS are at risk of aortic aneurysm formation and dissection. Usually, blood pressure\u2013lowering drugs are used to reduce aortic events; however, this is not sufficient for most patients. In the aorta of smooth muscle cell\u2013specific sirtuin-1\u2013deficient mice, spontaneous aneurysm formation and senescence are observed. Resveratrol is known to enhance sirtuin-1 activity and to reduce senescence, which prompted us to investigate the effectiveness of resveratrol in inhibition of aortic dilatation in the\n              <jats:italic>Fbn1<\/jats:italic>\n              <jats:sup>C1039G\/+<\/jats:sup>\n              MFS mouse model.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Approach and Results\u2014<\/jats:title>\n            <jats:p>Aortic senescence strongly correlates with aortic root dilatation rate in MFS mice. However, although resveratrol inhibits aortic dilatation, it only shows a trend toward reduced aortic senescence. Resveratrol enhances nuclear localization of sirtuin-1 in the vessel wall and, in contrast to losartan, does not affect leukocyte infiltration nor activation of SMAD2 and extracellular signal\u2013regulated kinases 1\/2 (ERK1\/2). Interestingly, specific sirtuin-1 activation (SRT1720) or inhibition (sirtinol) in MFS mice does not affect aortic root dilatation rate, although senescence is changed. Resveratrol reduces aortic elastin breaks and decreases micro-RNA-29b expression coinciding with enhanced antiapoptotic Bcl-2 expression and decreased number of terminal apoptotic cells. In cultured smooth muscle cells, the resveratrol effect on micro-RNA-29b downregulation is endothelial cell and nuclear factor \u03baB-dependent.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Resveratrol inhibits aortic root dilatation in MFS mice by promoting elastin integrity and smooth muscle cell survival, involving downregulation of the aneurysm-related micro-RNA-29b in the aorta. On the basis of these data, resveratrol holds promise as a novel intervention strategy for patients with MFS.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/atvbaha.116.307841","type":"journal-article","created":{"date-parts":[[2016,6,10]],"date-time":"2016-06-10T02:53:55Z","timestamp":1465527235000},"page":"1618-1626","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":68,"title":["Resveratrol Inhibits Aortic Root Dilatation in the Fbn1\n            <sup>C1039G\/+<\/sup>\n            Marfan Mouse Model"],"prefix":"10.1161","volume":"36","author":[{"given":"Stijntje","family":"Hibender","sequence":"first","affiliation":[{"name":"From the Department of Medical Biochemistry (S.H., C.v.R., A.t.B., E.E.S., E.L., C.J.M.d.V., V.d.W.), Department of Cardiology (R.F., M.G., B.J.M.M.), Department of Experimental Cardiology (I.v.d.M., Y.M.P.), Heart Failure Research Center (Q.G., M.J.v.d.H.), Department of Radiology (M.G.), Department of Clinical Epidemiology and Biostatistics (A.H.Z.), Academic Medical Center, Amsterdam, The Netherlands; and Institute for Cardiovascular Prevention (IPEK) and Ludwig Maximilians University, Munich,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romy","family":"Franken","sequence":"additional","affiliation":[{"name":"From the Department of Medical Biochemistry (S.H., C.v.R., A.t.B., E.E.S., E.L., C.J.M.d.V., V.d.W.), Department of Cardiology (R.F., M.G., B.J.M.M.), Department of Experimental Cardiology (I.v.d.M., Y.M.P.), Heart Failure Research Center (Q.G., M.J.v.d.H.), Department of Radiology (M.G.), Department of Clinical Epidemiology and Biostatistics (A.H.Z.), Academic Medical Center, Amsterdam, The Netherlands; and Institute for Cardiovascular Prevention (IPEK) and Ludwig Maximilians University, Munich,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy","family":"van Roomen","sequence":"additional","affiliation":[{"name":"From the Department of Medical Biochemistry (S.H., C.v.R., A.t.B., E.E.S., E.L., C.J.M.d.V., V.d.W.), Department of Cardiology (R.F., M.G., B.J.M.M.), Department of Experimental Cardiology (I.v.d.M., Y.M.P.), Heart Failure Research Center (Q.G., M.J.v.d.H.), Department of Radiology (M.G.), Department of Clinical Epidemiology and Biostatistics (A.H.Z.), Academic Medical Center, Amsterdam, The Netherlands; and Institute for Cardiovascular Prevention (IPEK) and Ludwig Maximilians University, Munich,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anique","family":"ter Braake","sequence":"additional","affiliation":[{"name":"From the Department of Medical Biochemistry (S.H., C.v.R., A.t.B., E.E.S., E.L., C.J.M.d.V., V.d.W.), Department of Cardiology (R.F., M.G., B.J.M.M.), Department of Experimental Cardiology (I.v.d.M., Y.M.P.), Heart Failure Research Center (Q.G., M.J.v.d.H.), Department of Radiology (M.G.), Department of Clinical Epidemiology and Biostatistics (A.H.Z.), 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C.v.R., A.t.B., E.E.S., E.L., C.J.M.d.V., V.d.W.), Department of Cardiology (R.F., M.G., B.J.M.M.), Department of Experimental Cardiology (I.v.d.M., Y.M.P.), Heart Failure Research Center (Q.G., M.J.v.d.H.), Department of Radiology (M.G.), Department of Clinical Epidemiology and Biostatistics (A.H.Z.), Academic Medical Center, Amsterdam, The Netherlands; and Institute for Cardiovascular Prevention (IPEK) and Ludwig Maximilians University, Munich,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quinn","family":"Gunst","sequence":"additional","affiliation":[{"name":"From the Department of Medical Biochemistry (S.H., C.v.R., A.t.B., E.E.S., E.L., C.J.M.d.V., V.d.W.), Department of Cardiology (R.F., M.G., B.J.M.M.), Department of Experimental Cardiology (I.v.d.M., Y.M.P.), Heart Failure Research Center (Q.G., M.J.v.d.H.), Department of Radiology (M.G.), Department of Clinical Epidemiology and Biostatistics (A.H.Z.), Academic Medical Center, Amsterdam, The Netherlands; and Institute for Cardiovascular Prevention (IPEK) and Ludwig Maximilians University, Munich,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice J.","family":"van den Hoff","sequence":"additional","affiliation":[{"name":"From the Department of Medical Biochemistry (S.H., C.v.R., A.t.B., E.E.S., E.L., C.J.M.d.V., V.d.W.), Department of Cardiology (R.F., M.G., B.J.M.M.), Department of Experimental Cardiology (I.v.d.M., Y.M.P.), Heart Failure Research Center (Q.G., M.J.v.d.H.), Department of Radiology (M.G.), Department of Clinical Epidemiology and Biostatistics (A.H.Z.), Academic Medical Center, Amsterdam, The Netherlands; and Institute for Cardiovascular Prevention (IPEK) and Ludwig Maximilians University, Munich,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Lutgens","sequence":"additional","affiliation":[{"name":"From the Department of Medical Biochemistry (S.H., C.v.R., A.t.B., E.E.S., E.L., C.J.M.d.V., V.d.W.), 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