{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T19:42:34Z","timestamp":1790106154500,"version":"4.0.1"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec>\n            <jats:title>Objective\u2014<\/jats:title>\n            <jats:p>The function of high-density lipoproteins (HDLs) may better reflect their atheroprotective role, compared with HDL-cholesterol levels. The association between DNA methylation and HDL function has not yet been established.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Approach and Results\u2014<\/jats:title>\n            <jats:p>\n              We designed an epigenome-wide association study including 645 individuals from the REGICOR study (Registre Gironi del Cor). We determined DNA methylation from peripheral blood cells using the HumanMethylation450 array. We analyzed HDL functionality by determining HDL cholesterol efflux capacity and HDL inflammatory index. We discovered 3 methylation sites located in\n              <jats:italic>HOXA3<\/jats:italic>\n              ,\n              <jats:italic>PEX5<\/jats:italic>\n              , and\n              <jats:italic>PER3<\/jats:italic>\n              related to cholesterol efflux capacity and 1 located in\n              <jats:italic>GABRR1<\/jats:italic>\n              related to HDL inflammatory index. Using a candidate gene approach, we also found 2 methylation sites located in\n              <jats:italic>CMIP<\/jats:italic>\n              related to cholesterol efflux capacity.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>\n              We identified 6 potential loci associated with HDL functionality in\n              <jats:italic>HOXA3<\/jats:italic>\n              ,\n              <jats:italic>PEX5<\/jats:italic>\n              ,\n              <jats:italic>PER3, CMIP<\/jats:italic>\n              , and\n              <jats:italic>GABRR1<\/jats:italic>\n              . Additional studies are warranted to validate these findings in other populations.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/atvbaha.116.308831","type":"journal-article","created":{"date-parts":[[2017,1,6]],"date-time":"2017-01-06T03:10:42Z","timestamp":1483672242000},"page":"567-569","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":16,"title":["DNA Methylation and High-Density Lipoprotein Functionality\u2014Brief Report"],"prefix":"10.1161","volume":"37","author":[{"given":"Sergi","family":"Sayols-Baixeras","sequence":"first","affiliation":[{"name":"From the IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain (S.S.-B., A.H., I.S., C.L.-G., D.M., M.F., J.M., R.E.); Universitat Pompeu Fabra (UPF), Barcelona, Spain (S.S.-B.); and CIBER (Centro de Investigaci\u00f3n Biom\u00e9dica en Red) de Enfermedades Cardiovasculares (CIBERCV) (S.S.-B., J.M., R.E.), CIBER de Fisiopatolog\u00eda de la Nutrici\u00f3n y la Obesidad (CIBEROBN) (A.H., D.M., M.F.) and CIBER de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP) (I.S.), Instituto de Salud Carlos III, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Hern\u00e1ez","sequence":"additional","affiliation":[{"name":"From the IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain (S.S.-B., A.H., I.S., C.L.-G., D.M., M.F., J.M., R.E.); Universitat Pompeu Fabra (UPF), Barcelona, Spain (S.S.-B.); and CIBER (Centro de Investigaci\u00f3n Biom\u00e9dica en Red) de Enfermedades Cardiovasculares (CIBERCV) (S.S.-B., J.M., R.E.), CIBER de Fisiopatolog\u00eda de la Nutrici\u00f3n y la Obesidad (CIBEROBN) (A.H., D.M., M.F.) and CIBER de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP) (I.S.), Instituto de Salud Carlos III, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Issac","family":"Subirana","sequence":"additional","affiliation":[{"name":"From the IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain (S.S.-B., A.H., I.S., C.L.-G., D.M., M.F., J.M., R.E.); Universitat Pompeu Fabra (UPF), Barcelona, Spain (S.S.-B.); and CIBER (Centro de Investigaci\u00f3n Biom\u00e9dica en Red) de Enfermedades Cardiovasculares (CIBERCV) (S.S.-B., J.M., R.E.), CIBER de Fisiopatolog\u00eda de la Nutrici\u00f3n y la Obesidad (CIBEROBN) (A.H., D.M., M.F.) and CIBER de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP) (I.S.), Instituto de Salud Carlos III, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Lluis-Ganella","sequence":"additional","affiliation":[{"name":"From the IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain (S.S.-B., A.H., I.S., C.L.-G., D.M., M.F., J.M., R.E.); Universitat Pompeu Fabra (UPF), Barcelona, Spain (S.S.-B.); and CIBER (Centro de Investigaci\u00f3n Biom\u00e9dica en Red) de Enfermedades Cardiovasculares (CIBERCV) (S.S.-B., J.M., R.E.), CIBER de Fisiopatolog\u00eda de la Nutrici\u00f3n y la Obesidad (CIBEROBN) (A.H., D.M., M.F.) and CIBER de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP) (I.S.), Instituto de Salud Carlos III, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"From the IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain (S.S.-B., A.H., I.S., C.L.-G., D.M., M.F., J.M., R.E.); Universitat Pompeu Fabra (UPF), Barcelona, Spain (S.S.-B.); and CIBER (Centro de Investigaci\u00f3n Biom\u00e9dica en Red) de Enfermedades Cardiovasculares (CIBERCV) (S.S.-B., J.M., R.E.), CIBER de Fisiopatolog\u00eda de la Nutrici\u00f3n y la Obesidad (CIBEROBN) (A.H., D.M., M.F.) and CIBER de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP) (I.S.), Instituto de Salud Carlos III, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Fit\u00f3","sequence":"additional","affiliation":[{"name":"From the IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain (S.S.-B., A.H., I.S., C.L.-G., D.M., M.F., J.M., R.E.); Universitat Pompeu Fabra (UPF), Barcelona, Spain (S.S.-B.); and CIBER (Centro de Investigaci\u00f3n Biom\u00e9dica en Red) de Enfermedades Cardiovasculares (CIBERCV) (S.S.-B., J.M., R.E.), CIBER de Fisiopatolog\u00eda de la Nutrici\u00f3n y la Obesidad (CIBEROBN) (A.H., D.M., M.F.) and CIBER de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP) (I.S.), Instituto de Salud Carlos III, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaume","family":"Marrugat","sequence":"additional","affiliation":[{"name":"From the IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain (S.S.-B., A.H., I.S., C.L.-G., D.M., M.F., J.M., R.E.); Universitat Pompeu Fabra (UPF), Barcelona, Spain (S.S.-B.); and CIBER (Centro de Investigaci\u00f3n Biom\u00e9dica en Red) de Enfermedades Cardiovasculares (CIBERCV) (S.S.-B., J.M., R.E.), CIBER de Fisiopatolog\u00eda de la Nutrici\u00f3n y la Obesidad (CIBEROBN) (A.H., D.M., M.F.) and CIBER de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP) (I.S.), Instituto de Salud Carlos III, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Elosua","sequence":"additional","affiliation":[{"name":"From the IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain (S.S.-B., A.H., I.S., C.L.-G., D.M., M.F., J.M., R.E.); Universitat Pompeu Fabra (UPF), Barcelona, Spain (S.S.-B.); and CIBER (Centro de Investigaci\u00f3n Biom\u00e9dica en Red) de Enfermedades Cardiovasculares (CIBERCV) (S.S.-B., J.M., R.E.), CIBER de Fisiopatolog\u00eda de la Nutrici\u00f3n y la Obesidad (CIBEROBN) (A.H., D.M., M.F.) and CIBER de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP) (I.S.), Instituto de Salud Carlos III, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-014-0429-x"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad3517"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1409065"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.08.030"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddw285"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09270"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2797"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.300738"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2014.185"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2009.07.002"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R005959"}],"container-title":["Arteriosclerosis, Thrombosis, and Vascular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/ATVBAHA.116.308831","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T23:19:28Z","timestamp":1715555968000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/ATVBAHA.116.308831"}},"subtitle":["The REGICOR Study (Registre Gironi del Cor)"],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1161\/ATVBAHA.116.308831"],"URL":"https:\/\/doi.org\/10.1161\/atvbaha.116.308831","relation":{},"ISSN":["1079-5642","1524-4636"],"issn-type":[{"value":"1079-5642","type":"print"},{"value":"1524-4636","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"2016-08-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-12-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-01-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}