{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T06:25:20Z","timestamp":1790490320263,"version":"4.1.0"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec>\n            <jats:title>Objective\u2014<\/jats:title>\n            <jats:p>Experimental studies suggest that maternal hypercholesterolemia may be relevant for the early onset of cardiovascular disease in offspring. We investigated the effect of perinatal hypercholesterolemia on the atherosclerosis development in the offspring of apolipoprotein E\u2013deficient mice and the underlying mechanism.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Approach and Results\u2014<\/jats:title>\n            <jats:p>\n              Atherosclerosis and related parameters were studied in adult male or female apolipoprotein E\u2013deficient mice offspring from either normocholesterolemic or hypercholesterolemic mothers and normocholesterolemic fathers. Female born to hypercholesterolemic mothers had more aortic root lesions than female born to normocholesterolemic mothers. Lesions in whole aorta did not differ between groups. Higher trimethylamine-N-oxide levels and\n              <jats:italic>Fmo3<\/jats:italic>\n              hepatic gene expression were higher in female born to hypercholesterolemic mothers offspring compared with female born to normocholesterolemic mothers and male. Trimethylamine-N-oxide levels were correlated with the size of atherosclerotic root lesions. Levels of hepatic cholesterol and gallbladder bile acid were greater in male born to hypercholesterolemic mothers compared with male born to normocholesterolemic mothers. At 18 weeks of age, female born to hypercholesterolemic mothers showed lower hepatic\n              <jats:italic>Scarb1<\/jats:italic>\n              and\n              <jats:italic>Cyp7a1<\/jats:italic>\n              but higher\n              <jats:italic>Nr1h4<\/jats:italic>\n              gene expression compared with female born to normocholesterolemic mothers. Male born to hypercholesterolemic mothers showed an increase in\n              <jats:italic>Scarb1<\/jats:italic>\n              and\n              <jats:italic>Ldlr<\/jats:italic>\n              gene expression compared with male born to normocholesterolemic mothers. At 25 weeks of age, female born to hypercholesterolemic mothers had lower\n              <jats:italic>Cyp7a1<\/jats:italic>\n              gene expression compared with female born to normocholesterolemic mothers. DNA methylation of\n              <jats:italic>Fmo3, Scarb1<\/jats:italic>\n              , and\n              <jats:italic>Ldlr<\/jats:italic>\n              promoter regions was slightly modified and may explain the mRNA expression modulation.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Our findings suggest that maternal hypercholesterolemia may exacerbate the development of atherosclerosis in female offspring by affecting metabolism of trimethylamine-N-oxide and bile acids. These data could be explained by epigenetic alterations.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/atvbaha.117.309923","type":"journal-article","created":{"date-parts":[[2017,9,22]],"date-time":"2017-09-22T01:10:37Z","timestamp":1506042637000},"page":"2053-2063","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":44,"title":["Perinatal Hypercholesterolemia Exacerbates Atherosclerosis Lesions in Offspring by Altering Metabolism of Trimethylamine-N-Oxide and Bile Acids"],"prefix":"10.1161","volume":"37","author":[{"given":"Charlotte","family":"Trenteseaux","sequence":"first","affiliation":[{"name":"From the UMR 1280 Physiopathologie des Adaptations Nutritionnelles, INRA, Universit\u00e9 de Nantes, France (C.T., G.P., P.d.C., V.A., M.K., E.N.-D., K.O.); Centre de Recherche en Nutrition Humaine Ouest, Nantes, France (C.T., A.A., M.K., K.O.); UMR1063 Stress Oxydant et Pathologies M\u00e9taboliques, INSERM, Universit\u00e9 d\u2019Angers, France (C.T., R.A.); and UMR 1148 Laboratoire de recherche Vasculaire Translationnelle, INSERM, Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, Universit\u00e9 Paris, France (A.-t.G., J.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anh-thu","family":"Gaston","sequence":"additional","affiliation":[{"name":"From the UMR 1280 Physiopathologie des Adaptations Nutritionnelles, INRA, Universit\u00e9 de Nantes, France (C.T., G.P., P.d.C., V.A., M.K., E.N.-D., K.O.); Centre de Recherche en Nutrition Humaine Ouest, Nantes, France (C.T., A.A., M.K., K.O.); UMR1063 Stress Oxydant et Pathologies M\u00e9taboliques, INSERM, Universit\u00e9 d\u2019Angers, France (C.T., R.A.); and UMR 1148 Laboratoire de recherche Vasculaire Translationnelle, INSERM, Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, Universit\u00e9 Paris, France (A.-t.G., J.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Aguesse","sequence":"additional","affiliation":[{"name":"From the UMR 1280 Physiopathologie des Adaptations Nutritionnelles, INRA, Universit\u00e9 de Nantes, France (C.T., G.P., P.d.C., V.A., M.K., E.N.-D., K.O.); Centre de Recherche en Nutrition Humaine Ouest, Nantes, France (C.T., A.A., M.K., K.O.); UMR1063 Stress Oxydant et Pathologies M\u00e9taboliques, INSERM, Universit\u00e9 d\u2019Angers, France (C.T., R.A.); and UMR 1148 Laboratoire de recherche Vasculaire Translationnelle, INSERM, Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, Universit\u00e9 Paris, France (A.-t.G., J.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Poupeau","sequence":"additional","affiliation":[{"name":"From the UMR 1280 Physiopathologie des Adaptations Nutritionnelles, INRA, Universit\u00e9 de Nantes, France (C.T., G.P., P.d.C., V.A., M.K., E.N.-D., K.O.); Centre de Recherche en Nutrition Humaine Ouest, Nantes, France (C.T., A.A., M.K., K.O.); UMR1063 Stress Oxydant et Pathologies M\u00e9taboliques, INSERM, Universit\u00e9 d\u2019Angers, France (C.T., R.A.); and UMR 1148 Laboratoire de recherche Vasculaire Translationnelle, INSERM, Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, Universit\u00e9 Paris, France (A.-t.G., J.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"de Coppet","sequence":"additional","affiliation":[{"name":"From the UMR 1280 Physiopathologie des Adaptations Nutritionnelles, INRA, Universit\u00e9 de Nantes, France (C.T., G.P., P.d.C., V.A., M.K., E.N.-D., K.O.); Centre de Recherche en Nutrition Humaine Ouest, Nantes, France (C.T., A.A., M.K., K.O.); UMR1063 Stress Oxydant et Pathologies M\u00e9taboliques, INSERM, Universit\u00e9 d\u2019Angers, France (C.T., R.A.); and UMR 1148 Laboratoire de recherche Vasculaire Translationnelle, INSERM, Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, Universit\u00e9 Paris, France (A.-t.G., J.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramaroson","family":"Andriantsitohaina","sequence":"additional","affiliation":[{"name":"From the UMR 1280 Physiopathologie des Adaptations Nutritionnelles, INRA, Universit\u00e9 de Nantes, France (C.T., G.P., P.d.C., V.A., M.K., E.N.-D., K.O.); Centre de Recherche en Nutrition Humaine Ouest, Nantes, France (C.T., A.A., M.K., K.O.); UMR1063 Stress Oxydant et Pathologies M\u00e9taboliques, INSERM, Universit\u00e9 d\u2019Angers, France (C.T., R.A.); and UMR 1148 Laboratoire de recherche Vasculaire Translationnelle, INSERM, Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, Universit\u00e9 Paris, France (A.-t.G., J.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamila","family":"Laschet","sequence":"additional","affiliation":[{"name":"From the UMR 1280 Physiopathologie des Adaptations Nutritionnelles, INRA, Universit\u00e9 de Nantes, France 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