{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:42:18Z","timestamp":1790649738586,"version":"4.1.0"},"reference-count":111,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec>\n            <jats:title>Objective\u2014<\/jats:title>\n            <jats:p>Diabetic macular edema is a major cause of visual impairment. It is caused by blood-retinal barrier breakdown that leads to vascular hyperpermeability. Current therapeutic approaches consist of retinal photocoagulation or targeting VEGF (vascular endothelial growth factor) to limit vascular leakage. However, long-term intravitreal use of anti-VEGFs is associated with potential safety issues, and the identification of alternative regulators of vascular permeability may provide safer therapeutic options. The vascular specific BMP (bone morphogenetic protein) receptor ALK1 (activin-like kinase receptor type I) and its circulating ligand BMP9 have been shown to be potent vascular quiescence factors, but their role in the context of microvascular permeability associated with hyperglycemia has not been evaluated.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Approach and Results\u2014<\/jats:title>\n            <jats:p>We investigated Alk1 signaling in hyperglycemic endothelial cells and assessed whether BMP9\/Alk1 signaling could modulate vascular permeability. We show that high glucose concentrations impair Alk1 signaling, both in cultured endothelial cells and in a streptozotocin model of mouse diabetes mellitus. We observed that Alk1 signaling participates in the maintenance of vascular barrier function, as Alk1 haploinsufficiency worsens the vascular leakage observed in diabetic mice. Conversely, sustained delivery of BMP9 by adenoviral vectors significantly decreased the loss of retinal barrier function in diabetic mice. Mechanistically, we demonstrate that Alk1 signaling prevents VEGF-induced phosphorylation of VE-cadherin and induces the expression of occludin, thus strengthening vascular barrier functions.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>From these data, we suggest that by preventing retinal vascular permeability, BMP9 could serve as a novel therapeutic agent for diabetic macular edema.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/atvbaha.118.310733","type":"journal-article","created":{"date-parts":[[2018,6,7]],"date-time":"2018-06-07T09:00:02Z","timestamp":1528362002000},"page":"1821-1836","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":59,"title":["BMP9 (Bone Morphogenetic Protein-9)\/Alk1 (Activin-Like Kinase Receptor Type I) Signaling Prevents Hyperglycemia-Induced Vascular Permeability"],"prefix":"10.1161","volume":"38","author":[{"given":"Naoufal","family":"Akla","sequence":"first","affiliation":[{"name":"From the Department of Biochemistry (N.A., P.S.)"},{"name":"University of Montreal, Quebec, Canada; and Maisonneuve-Rosemont Hospital Research Center, Montreal, Quebec, Canada (N.A., C.V., N.P., C.L.G., P.S., B.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Viallard","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology (C.V., B.L.)"},{"name":"University of Montreal, Quebec, Canada; and Maisonneuve-Rosemont Hospital Research Center, Montreal, Quebec, Canada (N.A., C.V., N.P., C.L.G., P.S., B.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalija","family":"Popovic","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences (N.P., C.L.G., B.L.)"},{"name":"University of Montreal, Quebec, Canada; and Maisonneuve-Rosemont Hospital Research Center, Montreal, Quebec, Canada (N.A., C.V., N.P., C.L.G., P.S., B.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy","family":"Lora Gil","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences (N.P., C.L.G., B.L.)"},{"name":"University of Montreal, Quebec, Canada; and Maisonneuve-Rosemont Hospital Research Center, Montreal, Quebec, Canada (N.A., C.V., N.P., C.L.G., P.S., B.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Przemyslaw","family":"Sapieha","sequence":"additional","affiliation":[{"name":"From the Department of Biochemistry (N.A., P.S.)"},{"name":"Department of Ophthalmology (P.S., B.L.)"},{"name":"University of Montreal, Quebec, Canada; and Maisonneuve-Rosemont Hospital Research Center, Montreal, Quebec, Canada (N.A., C.V., N.P., C.L.G., P.S., B.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Larriv\u00e9e","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology (C.V., B.L.)"},{"name":"Department of Biomedical Sciences (N.P., C.L.G., B.L.)"},{"name":"Department of Ophthalmology (P.S., B.L.)"},{"name":"University of Montreal, Quebec, Canada; and Maisonneuve-Rosemont Hospital Research Center, Montreal, Quebec, Canada (N.A., C.V., N.P., C.L.G., P.S., B.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/918267"},{"key":"e_1_3_5_3_2","volume-title":"Handbook of Diabetes","author":"Williams G","year":"2004","unstructured":"Williams, G, Pickup, JC. Handbook of Diabetes. Wiley; 2004."},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.183480"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20080008"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.93751"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40662-015-0026-2"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v2.i6.98"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-1580"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.4103\/2008-322X.143378"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2156273"},{"key":"e_1_3_5_12_2","first-page":"574","article-title":"Vascular endothelial growth factor\/vascular permeability factor is temporally and spatially correlated with ocular angiogenesis in a primate model.","volume":"145","author":"Miller JW","year":"1994","unstructured":"Miller, JW, Adamis, AP, Shima, DT, D\u2019Amore, PA, Moulton, RS, O\u2019Reilly, MS, Folkman, J, Dvorak, HF, Brown, LF, Berse, B. Vascular endothelial growth factor\/vascular permeability factor is temporally and spatially correlated with ocular angiogenesis in a primate model. Am J Pathol. 1994;145:574\u2013584.","journal-title":"Am J Pathol"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/2045-3701-4-27"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2013.02.001"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.3109\/08820539909069543"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a002899"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.47.3.401"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00012.2005"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1086\/677356"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2009.01.004"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2013.08.020"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.06.006"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.8265.1"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.18240\/ijo.2017.05.17"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S128509"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1177\/2042018813512360"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2013.107"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.11.012"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000095246.40391.3B"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-07-235655"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/81634"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-017-2636-4"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.6.3672"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2011.44.10.619"},{"key":"e_1_3_5_35_2","first-page":"1","article-title":"BMP9 signaling in stem cell differentiation and osteogenesis.","volume":"2","author":"Lamplot JD","year":"2013","unstructured":"Lamplot, JD, Qin, J, Nan, G, . BMP9 signaling in stem cell differentiation and osteogenesis. Am J Stem Cells. 2013;2:1\u201321.","journal-title":"Am J Stem Cells"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2012.02.005"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-011-0751-1"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-07-034124"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M503328200"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.377960"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.165530"},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2009.05.001"},{"key":"e_1_3_5_43_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-08-107359"},{"key":"e_1_3_5_44_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI39482"},{"key":"e_1_3_5_45_2","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000648"},{"key":"e_1_3_5_46_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.6.2626"},{"key":"e_1_3_5_47_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.135.6.7988458"},{"key":"e_1_3_5_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/0471141755.ph0547s40"},{"key":"e_1_3_5_49_2","first-page":"789","article-title":"Sensitive blood-retinal barrier breakdown quantitation using Evans blue.","volume":"42","author":"Xu Q","year":"2001","unstructured":"Xu, Q, Qaum, T, Adamis, AP. Sensitive blood-retinal barrier breakdown quantitation using Evans blue. Invest Ophthalmol Vis Sci. 2001;42:789\u2013794.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_3_5_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.09.003"},{"key":"e_1_3_5_51_2","first-page":"e50062","article-title":"An in vivo assay to test blood vessel permeability.","author":"Radu M","year":"2013","unstructured":"Radu, M, Chernoff, J. An in vivo assay to test blood vessel permeability. J Vis Exp. 2013:e50062.","journal-title":"J Vis Exp"},{"key":"e_1_3_5_52_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvt238"},{"key":"e_1_3_5_53_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V100.4.1334.h81602001334_1334_1339"},{"key":"e_1_3_5_54_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00462.2010"},{"key":"e_1_3_5_55_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.92.2379.112"},{"key":"e_1_3_5_56_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2004235"},{"key":"e_1_3_5_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13516"},{"key":"e_1_3_5_58_2","first-page":"356","article-title":"The streptozotocin-induced diabetic nude mouse model: differences between animals from different sources.","volume":"61","author":"Graham ML","year":"2011","unstructured":"Graham, ML, Janecek, JL, Kittredge, JA, Hering, BJ, Schuurman, HJ. The streptozotocin-induced diabetic nude mouse model: differences between animals from different sources. Comp Med. 2011;61:356\u2013360.","journal-title":"Comp Med"},{"key":"e_1_3_5_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3877"},{"key":"e_1_3_5_60_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013444"},{"key":"e_1_3_5_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)62255-9"},{"key":"e_1_3_5_62_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-012-2625-y"},{"key":"e_1_3_5_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2016.06.016"},{"key":"e_1_3_5_64_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI35298"},{"key":"e_1_3_5_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt795"},{"key":"e_1_3_5_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.04.056"},{"key":"e_1_3_5_67_2","first-page":"1774","article-title":"Purification and NH2-terminal amino acid sequence of guinea pig tumor-secreted vascular permeability factor.","volume":"50","author":"Senger DR","year":"1990","unstructured":"Senger, DR, Connolly, DT, Van de Water, L, Feder, J, Dvorak, HF. Purification and NH2-terminal amino acid sequence of guinea pig tumor-secreted vascular permeability factor. Cancer Res. 1990;50:1774\u20131778.","journal-title":"Cancer Res"},{"key":"e_1_3_5_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80221-X"},{"key":"e_1_3_5_69_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000245821.77155.c3"},{"key":"e_1_3_5_70_2","first-page":"6651","article-title":"Inhibition of angiogenesis and vascular leakiness by angiopoietin-related protein 4.","volume":"63","author":"Ito Y","year":"2003","unstructured":"Ito, Y, Oike, Y, Yasunaga, K, Hamada, K, Miyata, K, Matsumoto, S, Sugano, S, Tanihara, H, Masuho, Y, Suda, T. Inhibition of angiogenesis and vascular leakiness by angiopoietin-related protein 4. Cancer Res. 2003;63:6651\u20136657.","journal-title":"Cancer Res"},{"key":"e_1_3_5_71_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20111343"},{"key":"e_1_3_5_72_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20110301"},{"key":"e_1_3_5_73_2","doi-asserted-by":"publisher","DOI":"10.4161\/cam.29026"},{"key":"e_1_3_5_74_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8696481"},{"key":"e_1_3_5_75_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2824"},{"key":"e_1_3_5_76_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200209019"},{"key":"e_1_3_5_77_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001250100588"},{"key":"e_1_3_5_78_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-5147"},{"key":"e_1_3_5_79_2","doi-asserted-by":"publisher","DOI":"10.3109\/03009734.2015.1064501"},{"key":"e_1_3_5_80_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-2002"},{"key":"e_1_3_5_81_2","doi-asserted-by":"publisher","DOI":"10.1080\/02713680500263598"},{"key":"e_1_3_5_82_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6702716"},{"key":"e_1_3_5_83_2","doi-asserted-by":"publisher","DOI":"10.1124\/pr.57.2.4"},{"key":"e_1_3_5_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2004.07.005"},{"key":"e_1_3_5_85_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2005.04266.x"},{"key":"e_1_3_5_86_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.81.3.363"},{"key":"e_1_3_5_87_2","first-page":"383","article-title":"Pharmacologic therapies for diabetic retinopathy and diabetic macular edema.","volume":"1","author":"Rechtman E","year":"2007","unstructured":"Rechtman, E, Harris, A, Garzozi, HJ, Ciulla, TA. Pharmacologic therapies for diabetic retinopathy and diabetic macular edema. Clin Ophthalmol. 2007;1:383\u2013391.","journal-title":"Clin Ophthalmol"},{"key":"e_1_3_5_88_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000091257.27563.32"},{"key":"e_1_3_5_89_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/794036"},{"key":"e_1_3_5_90_2","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.178154"},{"key":"e_1_3_5_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2008.10.001"},{"key":"e_1_3_5_92_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1534"},{"key":"e_1_3_5_93_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI84767"},{"key":"e_1_3_5_94_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2011.05.011"},{"key":"e_1_3_5_95_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-0556"},{"key":"e_1_3_5_96_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.6_suppl.585S"},{"key":"e_1_3_5_97_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000159936.38601.22"},{"key":"e_1_3_5_98_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-01-199166"},{"key":"e_1_3_5_99_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13650"},{"key":"e_1_3_5_100_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-01-407593"},{"key":"e_1_3_5_101_2","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2008.46"},{"key":"e_1_3_5_102_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-0995"},{"key":"e_1_3_5_103_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2009.01.006"},{"key":"e_1_3_5_104_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.47.12.1953"},{"key":"e_1_3_5_105_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.33.23463"},{"key":"e_1_3_5_106_2","first-page":"3561","article-title":"Altered expression of retinal occludin and glial fibrillary acidic protein in experimental diabetes. The Penn State Retina Research Group.","volume":"41","author":"Barber AJ","year":"2000","unstructured":"Barber, AJ, Antonetti, DA, Gardner, TW. Altered expression of retinal occludin and glial fibrillary acidic protein in experimental diabetes. The Penn State Retina Research Group. Invest Ophthalmol Vis Sci. 2000;41:3561\u20133568.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_3_5_107_2","doi-asserted-by":"publisher","DOI":"10.2337\/db06-1694"},{"key":"e_1_3_5_108_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI20702"},{"key":"e_1_3_5_109_2","doi-asserted-by":"publisher","DOI":"10.1186\/1478-811X-7-12"},{"key":"e_1_3_5_110_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.5.1535"},{"key":"e_1_3_5_111_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2199-11-51"},{"key":"e_1_3_5_112_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M303810200"}],"container-title":["Arteriosclerosis, Thrombosis, and Vascular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/ATVBAHA.118.310733","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:43:11Z","timestamp":1715553791000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/ATVBAHA.118.310733"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":111,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1161\/ATVBAHA.118.310733"],"URL":"https:\/\/doi.org\/10.1161\/atvbaha.118.310733","relation":{},"ISSN":["1079-5642","1524-4636"],"issn-type":[{"value":"1079-5642","type":"print"},{"value":"1524-4636","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"2018-01-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}