{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T22:37:27Z","timestamp":1771713447835,"version":"3.50.1"},"reference-count":203,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:p>Vasculitis is a systemic disease characterized by immune-mediated injury of blood vessels. Current treatments for vasculitis, such as glucocorticoids and alkylating agents, are associated with significant side effects. Furthermore, the management of both small and large vessel vasculitis is challenging because of a lack of robust markers of disease activity. Recent research has advanced our understanding of the pathogenesis of both small and large vessel vasculitis, and this has led to the development of novel biologic therapies capable of targeting key cytokine and cellular effectors of the inflammatory cascade. In parallel, a diverse range of imaging modalities with the potential to monitor vessel inflammation are emerging. Continued expansion of combined structural and molecular imaging using positron emission tomography with computed tomography or magnetic resonance imaging may soon provide reliable longitudinal tracking of vascular inflammation. In addition, the emergence of radiotracers able to assess macrophage activation and immune checkpoint activity represents an exciting new frontier in imaging vascular inflammation. In the near future, these advances will allow more precise imaging of disease activity enabling clinicians to offer more targeted and individualized patient management.<\/jats:p>","DOI":"10.1161\/atvbaha.118.310957","type":"journal-article","created":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T09:00:37Z","timestamp":1560416437000},"page":"1520-1541","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":27,"title":["Advances in Therapies and Imaging for Systemic Vasculitis"],"prefix":"10.1161","volume":"39","author":[{"given":"Tariq E.","family":"Farrah","sequence":"first","affiliation":[{"name":"From the University\/British Heart Foundation Centre of Research Excellence, Centre of Cardiovascular Science, The Queen\u2019s Medical Research Institute, University of Edinburgh, Scotland (T.E.F., M.D., N.D.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil","family":"Basu","sequence":"additional","affiliation":[{"name":"Institute of Infection, Immunity and Inflammation, University of Glasgow, Scotland (N.B.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Dweck","sequence":"additional","affiliation":[{"name":"From the University\/British Heart Foundation Centre of Research Excellence, Centre of Cardiovascular Science, The Queen\u2019s Medical Research Institute, University of Edinburgh, Scotland (T.E.F., M.D., N.D.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Calcagno","sequence":"additional","affiliation":[{"name":"Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York (C.C., Z.A.F.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahi A.","family":"Fayad","sequence":"additional","affiliation":[{"name":"Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York (C.C., Z.A.F.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neeraj","family":"Dhaun","sequence":"additional","affiliation":[{"name":"From the University\/British Heart Foundation Centre of Research Excellence, Centre of Cardiovascular Science, The Queen\u2019s Medical Research Institute, University of Edinburgh, Scotland (T.E.F., M.D., N.D.)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","first-page":"1","volume-title":"Arthritis Rheum","volume":"65","author":"Jennette JC","year":"2013","unstructured":"Jennette, JC, Falk, RJ, Bacon, PA, et al. 2012 revised international chapel hill consensus conference nomenclature of vasculitides. Arthritis Rheum. 2013;65:1\u201311."},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra022694"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199711203372106"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.13.1632"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/key285"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev262"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20433"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.59.3.161"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.046912"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.24459"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2010.10.008"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex424"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep153"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.012547"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev348"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.027094"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex459"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22754"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.45.2.136"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2016.08.015"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.7326\/M12-3046"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2013.161"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker163"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.872903"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201836"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.39037"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00560-2"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1613849"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv607"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.160.11.5294"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/key015"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211878"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.2217\/cer-2017-0022"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.2217\/imt-2017-0149"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2018.04.004"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.10.5319"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.40044"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.40037"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.39035"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.48.8.667"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-120-11-199406010-00004"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22404"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-212649"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-018-3973-8"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.3310\/hta20900"},{"key":"e_1_3_4_47_2","article-title":"Vessel wall plasticity in large vessel giant cell arteritis: an ultrasound follow-up study.","author":"Aschwanden M","year":"2018","unstructured":"Aschwanden, M, Schegk, E, Imfeld, S, Staub, D, Rottenburger, C, Berger, CT, Daikeler, T. Vessel wall plasticity in large vessel giant cell arteritis: an ultrasound follow-up study. Rheumatology. 2018: doi.10.1093\/rheumatology\/key1383","journal-title":"Rheumatology"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem322"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex461"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200865"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000004146"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000486"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j347"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-213102"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20150892"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.24911"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2016-309661"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.161467"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-34395-7"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-8051(97)00226-6"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-002-1018-8"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1998.274.3.E516"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2003.09.002"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.12.061"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-011-1967-x"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204572"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.108.051920"},{"issue":"3","key":"e_1_3_4_68_2","first-page":"S47","article-title":"[18F] FDG-PET\/CT as a new and sensitive imaging method for the diagnosis of large vessel vasculitis.","volume":"26","author":"Henes JC","year":"2008","unstructured":"Henes, JC, M\u00fcller, M, Krieger, J, Balletshofer, B, Pfannenberg, AC, Kanz, L, K\u00f6tter, I. [18F] FDG-PET\/CT as a new and sensitive imaging method for the diagnosis of large vessel vasculitis. Clin Exp Rheumatol. 2008;26(3 suppl 49):S47\u2013S52.","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-004-1757-9"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-003-1144-y"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00393-015-1674-2"},{"key":"e_1_3_4_72_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21699"},{"key":"e_1_3_4_73_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.40379"},{"key":"e_1_3_4_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2016.09.027"},{"key":"e_1_3_4_75_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.082123"},{"key":"e_1_3_4_76_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-018-4021-4"},{"key":"e_1_3_4_77_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2015.54"},{"key":"e_1_3_4_78_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.12.1156a"},{"key":"e_1_3_4_79_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.27240"},{"key":"e_1_3_4_80_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840090116"},{"key":"e_1_3_4_81_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000180792.80212.5e"},{"key":"e_1_3_4_82_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiographics.21.1.g01ja16151"},{"key":"e_1_3_4_83_2","first-page":"952","article-title":"Correlation of angiographic abnormalities with disease manifestations and disease severity in polyarteritis nodosa.","volume":"14","author":"Ewald EA","year":"1987","unstructured":"Ewald, EA, Griffin, D, McCune, WJ. Correlation of angiographic abnormalities with disease manifestations and disease severity in polyarteritis nodosa. J Rheumatol. 1987;14:952\u2013956.","journal-title":"J Rheumatol"},{"key":"e_1_3_4_84_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e318205a4c6"},{"key":"e_1_3_4_85_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199812)41:12<2100::AID-ART3>3.0.CO;2-J"},{"key":"e_1_3_4_86_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.088096"},{"key":"e_1_3_4_87_2","doi-asserted-by":"publisher","DOI":"10.3109\/14397595.2016.1172999"},{"key":"e_1_3_4_88_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfk082"},{"key":"e_1_3_4_89_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.028498"},{"key":"e_1_3_4_90_2","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2017-000446"},{"key":"e_1_3_4_91_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1307361"},{"key":"e_1_3_4_92_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1307362"},{"key":"e_1_3_4_93_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1109764"},{"issue":"111","key":"e_1_3_4_94_2","first-page":"177","article-title":"Diagnosis of deficiency of adenosine deaminase 2 with early onset polyarteritis nodosa in an adult patient with a novel compound heterozygous CECR1 mutation.","volume":"36","author":"Lamprecht P","year":"2018","unstructured":"Lamprecht, P, Humrich, JY, Diebold, I, Riemekasten, G. Diagnosis of deficiency of adenosine deaminase 2 with early onset polyarteritis nodosa in an adult patient with a novel compound heterozygous CECR1 mutation. Clin Exp Rheumatol. 2018;36(suppl 111):177.","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_3_4_95_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210802"},{"key":"e_1_3_4_96_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.96.09040632"},{"key":"e_1_3_4_97_2","doi-asserted-by":"publisher","DOI":"10.1177\/028418519103200212"},{"key":"e_1_3_4_98_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-008-9377-7"},{"key":"e_1_3_4_99_2","first-page":"323","article-title":"F-18-fluorodeoxyglucose positron emission tomography in diagnosis and follow-up of patients with different types of vasculitis.","volume":"61","author":"Bleeker-Rovers CP","year":"2003","unstructured":"Bleeker-Rovers, CP, Bredie, SJ, van der Meer, JW, Corstens, FH, Oyen, WJ. F-18-fluorodeoxyglucose positron emission tomography in diagnosis and follow-up of patients with different types of vasculitis. Neth J Med. 2003;61:323\u2013329.","journal-title":"Neth J Med"},{"key":"e_1_3_4_100_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2012.12.035"},{"key":"e_1_3_4_101_2","first-page":"876","article-title":"Regressing microaneurysms in 5 cases of hepatitis B virus related polyarteritis nodosa.","volume":"22","author":"Darras-Joly C","year":"1995","unstructured":"Darras-Joly, C, Lortholary, O, Cohen, P, Brauner, M, Guillevin, L. Regressing microaneurysms in 5 cases of hepatitis B virus related polyarteritis nodosa. J Rheumatol. 1995;22:876\u2013880.","journal-title":"J Rheumatol"},{"key":"e_1_3_4_102_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-008-0683-0"},{"key":"e_1_3_4_103_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfv022"},{"key":"e_1_3_4_104_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006091021"},{"key":"e_1_3_4_105_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1108735"},{"key":"e_1_3_4_106_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014090903"},{"key":"e_1_3_4_107_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.137778"},{"key":"e_1_3_4_108_2","doi-asserted-by":"publisher","DOI":"10.5152\/eurjrheum.2015.0043"},{"key":"e_1_3_4_109_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02500317"},{"key":"e_1_3_4_110_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.071936"},{"key":"e_1_3_4_111_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn318"},{"key":"e_1_3_4_112_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209133"},{"key":"e_1_3_4_113_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40674-017-0082-y"},{"key":"e_1_3_4_114_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197908023010503"},{"key":"e_1_3_4_115_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM19710429284170"},{"key":"e_1_3_4_116_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780160510"},{"key":"e_1_3_4_117_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780170404"},{"key":"e_1_3_4_118_2","first-page":"391","article-title":"XII. Differential effects of in vitro cyclophosphamide on human lymphocyte subpopulations involved in B-cell activation.","volume":"39","author":"Stevenson HC","year":"1980","unstructured":"Stevenson, HC, Fauci AS. Activation of human B lymphocytes. XII. Differential effects of in vitro cyclophosphamide on human lymphocyte subpopulations involved in B-cell activation. Immunology. 1980;39:391\u2013397.","journal-title":"Immunology"},{"key":"e_1_3_4_119_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2008.03775.x"},{"key":"e_1_3_4_120_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI15918"},{"key":"e_1_3_4_121_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0909905"},{"key":"e_1_3_4_122_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0909169"},{"key":"e_1_3_4_123_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1213277"},{"key":"e_1_3_4_124_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-206404"},{"key":"e_1_3_4_125_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1404231"},{"key":"e_1_3_4_126_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-212768"},{"key":"e_1_3_4_127_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-212878"},{"key":"e_1_3_4_128_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-017-1857-z"},{"key":"e_1_3_4_129_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-206095"},{"key":"e_1_3_4_130_2","unstructured":"US National Library of Medicine. Rituximab in Eosinophilic Granulomatosis With Polyangiitis (REOVAS). https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02807103."},{"key":"e_1_3_4_131_2","unstructured":"US National Library of Medicine. Maintenance of Remission With Rituximab Versus Azathioprine for Newly-diagnosed or Relapsing Eosinophilic Granulomatosis With Polyangiitis. (MAINRITSEG). https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03164473. Accessed 2019."},{"key":"e_1_3_4_132_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.02.009"},{"key":"e_1_3_4_133_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2014.11.009"},{"key":"e_1_3_4_134_2","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2014-000034"},{"key":"e_1_3_4_135_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200112)44:12<2836::AID-ART471>3.0.CO;2-W"},{"key":"e_1_3_4_136_2","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.150051"},{"key":"e_1_3_4_137_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209925"},{"key":"e_1_3_4_138_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1100994108"},{"key":"e_1_3_4_139_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199104000-00001"},{"key":"e_1_3_4_140_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1987.288"},{"key":"e_1_3_4_141_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar2923"},{"key":"e_1_3_4_142_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204164"},{"key":"e_1_3_4_143_2","unstructured":"US National Library of Medicine. Abatacept for the Treatment of Relapsing Non-Severe Granulomatosis With Polyangiitis (Wegener's). https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02108860. Accessed 2019."},{"key":"e_1_3_4_144_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2009.03115.x"},{"key":"e_1_3_4_145_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.081661"},{"key":"e_1_3_4_146_2","unstructured":"US National Library of Medicine. Alemtuzumab for ANCA Associated Refractory Vasculitis (ALEVIATE).1405807. Accessed January 2019."},{"key":"e_1_3_4_147_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-018-0065-x"},{"key":"e_1_3_4_148_2","doi-asserted-by":"publisher","DOI":"10.1159\/000323393"},{"key":"e_1_3_4_149_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2011.06.004"},{"key":"e_1_3_4_150_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.046219"},{"key":"e_1_3_4_151_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.30613"},{"key":"e_1_3_4_152_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200104053441406"},{"key":"e_1_3_4_153_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200104123441506"},{"key":"e_1_3_4_154_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn586"},{"key":"e_1_3_4_155_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.313"},{"key":"e_1_3_4_156_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2016.70"},{"key":"e_1_3_4_157_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008050497"},{"key":"e_1_3_4_158_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013020143"},{"key":"e_1_3_4_159_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016111179"},{"key":"e_1_3_4_160_2","unstructured":"US National Library of Medicine. A Phase 3 Clinical Trial of CCX168 (Avacopan) in Patients With ANCA-Associated Vasculitis (ADVOCATE). https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02994927. Accessed 2019."},{"key":"e_1_3_4_161_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2014.98"},{"key":"e_1_3_4_162_2","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000015"},{"key":"e_1_3_4_163_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.23496"},{"key":"e_1_3_4_164_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22834"},{"key":"e_1_3_4_165_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.37721"},{"key":"e_1_3_4_166_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.12206"},{"key":"e_1_3_4_167_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-155-5-201109060-00026"},{"issue":"1","key":"e_1_3_4_168_2","first-page":"S62","article-title":"Extended follow-up after stopping mepolizumab in relapsing\/refractory Churg-Strauss syndrome.","volume":"30","author":"Herrmann K","year":"2012","unstructured":"Herrmann, K, Gross, WL, Moosig, F. Extended follow-up after stopping mepolizumab in relapsing\/refractory Churg-Strauss syndrome. Clin Exp Rheumatol. 2012;30(1 suppl 70):S62\u2013S65.","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_3_4_169_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1702079"},{"key":"e_1_3_4_170_2","doi-asserted-by":"publisher","DOI":"10.1080\/02841850510021733"},{"key":"e_1_3_4_171_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket191"},{"key":"e_1_3_4_172_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2013.09.009"},{"key":"e_1_3_4_173_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.117366"},{"key":"e_1_3_4_174_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005121256"},{"key":"e_1_3_4_175_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.105692"},{"key":"e_1_3_4_176_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210792"},{"key":"e_1_3_4_177_2","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2015-207170"},{"key":"e_1_3_4_178_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199306173282402"},{"key":"e_1_3_4_179_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30772-X"},{"key":"e_1_3_4_180_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.189142"},{"key":"e_1_3_4_181_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.55.02.06.db05-0546"},{"key":"e_1_3_4_182_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.07.054"},{"key":"e_1_3_4_183_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-11503"},{"key":"e_1_3_4_184_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2013.05.021"},{"key":"e_1_3_4_185_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.89173"},{"key":"e_1_3_4_186_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex428"},{"key":"e_1_3_4_187_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2018.06.015"},{"key":"e_1_3_4_188_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2586(199911)10:5<751::AID-JMRI20>3.0.CO;2-Y"},{"key":"e_1_3_4_189_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.11.7360"},{"key":"e_1_3_4_190_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/687608"},{"key":"e_1_3_4_191_2","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/16422950"},{"key":"e_1_3_4_192_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2008.02.032"},{"key":"e_1_3_4_193_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-1331.2003.00571.x"},{"key":"e_1_3_4_194_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.02.063"},{"key":"e_1_3_4_195_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00048.2003"},{"key":"e_1_3_4_196_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2013.06.018"},{"key":"e_1_3_4_197_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.01.060"},{"key":"e_1_3_4_198_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200324228"},{"key":"e_1_3_4_199_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2011.12.009"},{"key":"e_1_3_4_200_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.3MA0717-283"},{"key":"e_1_3_4_201_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1616848114"},{"key":"e_1_3_4_202_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-013-1289-1"},{"key":"e_1_3_4_203_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0255-8"},{"key":"e_1_3_4_204_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07131-y"}],"container-title":["Arteriosclerosis, Thrombosis, and Vascular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/ATVBAHA.118.310957","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T23:09:42Z","timestamp":1715555382000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/ATVBAHA.118.310957"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":203,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1161\/ATVBAHA.118.310957"],"URL":"https:\/\/doi.org\/10.1161\/atvbaha.118.310957","relation":{},"ISSN":["1079-5642","1524-4636"],"issn-type":[{"value":"1079-5642","type":"print"},{"value":"1524-4636","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"2019-12-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}