{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:28:44Z","timestamp":1790141324950,"version":"4.0.1"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec>\n            <jats:title>Objective\u2014<\/jats:title>\n            <jats:p>Treatment with liraglutide, a GLP-1 (glucagon-like peptide-1) agonist, has been shown to reduce postprandial lipidemia, an important feature of diabetic dyslipidemia. However, the underlying mechanisms for this effect remain unknown. This prompted us to study the effect of liraglutide on the metabolism of ApoB48 (apolipoprotein B48).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Approach and Results\u2014<\/jats:title>\n            <jats:p>\n              We performed an in vivo kinetic study with stable isotopes (D\n              <jats:sub>8<\/jats:sub>\n              -valine) in the fed state in 10 patients with type 2 diabetes mellitus before treatment and 6 months after the initiation of treatment with liraglutide (1.2 mg\/d). We also evaluated, in mice, the effect of a 1-week liraglutide treatment on postload triglycerides and analysed in vitro on jejunum, the direct effect of liraglutide on the expression of genes involved in the biosynthesis of chylomicron. In diabetic patients, liraglutide treatment induced a dramatic reduction of ApoB48 pool (65\u00b138 versus 162\u00b187 mg;\n              <jats:italic>P<\/jats:italic>\n              =0.005) because of a significant decrease in ApoB48 production rate (3.02\u00b11.33 versus 6.14\u00b14.27 mg kg\n              <jats:sup>-1<\/jats:sup>\n              d\n              <jats:sup>-1<\/jats:sup>\n              ;\n              <jats:italic>P<\/jats:italic>\n              =0.009) and a significant increase in ApoB48 fractional catabolic rate (5.12\u00b11.35 versus 3.69\u00b10.75 pool d\n              <jats:sup>-1<\/jats:sup>\n              ;\n              <jats:italic>P<\/jats:italic>\n              =0.005). One-week treatment with liraglutide significantly reduced postload plasma triglycerides in mice and liraglutide, in vitro, reduced the expression of ApoB48, DGAT1 (diacylglycerol O-acyltransferase 1), and MTP (microsomal transfer protein) genes.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>We show that treatment with liraglutide induces a significant reduction of the ApoB48 pool because of both a reduction of ApoB48 production and an increase in ApoB48 catabolism. In vitro, liraglutide reduces the expression of genes involved in chylomicron synthesis. These effects might benefit cardiovascular health.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT02721888.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/atvbaha.118.310990","type":"journal-article","created":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T09:16:45Z","timestamp":1531991805000},"page":"2198-2206","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":68,"title":["Liraglutide Reduces Postprandial Hyperlipidemia by Increasing ApoB48 (Apolipoprotein B48) Catabolism and by Reducing ApoB48 Production in Patients With Type 2 Diabetes Mellitus"],"prefix":"10.1161","volume":"38","author":[{"given":"Bruno","family":"Verg\u00e8s","sequence":"first","affiliation":[{"name":"From the Department of Endocrinology-Diabetology (B.V., B.B, S.B.-R., A.R., A.-L.S., J.M.P.)"},{"name":"INSERM LNR UMR1231, University of Burgundy and Franche-Comt\u00e9, Dijon, France (B.V., L.D., J.P.P.d.B., B.B., J.-M.P., P.D., L.D.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Duvillard","sequence":"additional","affiliation":[{"name":"INSERM LNR UMR1231, University of Burgundy and Franche-Comt\u00e9, Dijon, France (B.V., L.D., J.P.P.d.B., B.B., J.-M.P., P.D., L.D.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Paul","family":"Pais de Barros","sequence":"additional","affiliation":[{"name":"INSERM LNR UMR1231, University of Burgundy and Franche-Comt\u00e9, Dijon, France (B.V., L.D., J.P.P.d.B., B.B., J.-M.P., P.D., L.D.)"},{"name":"Lipidomic Analytical Platform, B\u00e2timent B3, Dijon, France (J.P.P.d.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Bouillet","sequence":"additional","affiliation":[{"name":"From the Department of Endocrinology-Diabetology (B.V., B.B, S.B.-R., A.R., A.-L.S., J.M.P.)"},{"name":"INSERM LNR UMR1231, University of Burgundy and Franche-Comt\u00e9, Dijon, France (B.V., L.D., J.P.P.d.B., B.B., J.-M.P., P.D., L.D.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Baillot-Rudoni","sequence":"additional","affiliation":[{"name":"From the Department of Endocrinology-Diabetology (B.V., B.B, S.B.-R., A.R., A.-L.S., J.M.P.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexia","family":"Rouland","sequence":"additional","affiliation":[{"name":"From the Department of Endocrinology-Diabetology (B.V., B.B, S.B.-R., A.R., A.-L.S., J.M.P.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Laure","family":"Sberna","sequence":"additional","affiliation":[{"name":"From the Department of Endocrinology-Diabetology (B.V., B.B, S.B.-R., A.R., A.-L.S., J.M.P.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Michel","family":"Petit","sequence":"additional","affiliation":[{"name":"From the Department of Endocrinology-Diabetology (B.V., B.B, S.B.-R., A.R., A.-L.S., 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