{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T19:43:06Z","timestamp":1790106186800,"version":"4.0.1"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec>\n            <jats:title>Objective\u2014<\/jats:title>\n            <jats:p>HDL-C (high-density lipoprotein cholesterol) may not always be cardioprotective in postmenopausal women. HDL particles (HDL-P) via ion-mobility may better reflect the antiatherogenicity of HDL. Objectives were (1) to evaluate associations of HDL-C and ion-mobility HDL-P with carotid intima-media thickness (cIMT) and carotid plaque separately and jointly in women; and (2) to assess interactions by age at and time since menopause.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Approach and Results\u2014<\/jats:title>\n            <jats:p>\n              Analysis included 1380 females from the MESA (Multi-Ethnic Study of Atherosclerosis; age: 61.8\u00b110.3; 61% natural-, 21% surgical-, and 18% peri-menopause). Women with unknown or early menopause (age at nonsurgical menopause \u226445 years) were excluded. Adjusting for each other, higher HDL-P but not HDL-C was associated with lower cIMT (\n              <jats:italic>P<\/jats:italic>\n              =0.001), whereas higher HDL-C but not HDL-P was associated with greater risk of carotid plaque presence (\n              <jats:italic>P<\/jats:italic>\n              =0.04). Time since menopause significantly modified the association of large but not small HDL-P with cIMT; higher large HDL-P was associated with higher cIMT close to menopause but with lower cIMT later in life. The proatherogenic association reported for HDL-C with carotid plaque was most evident in women with later age at menopause who were &gt;10 years postmenopausal.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Elevated HDL-C may not always be cardioprotective in postmenopausal women. The cardioprotective capacity of large HDL-P may adversely compromise close to menopause supporting the importance of assessing how the menopause transition might impact HDL quality and related cardiovascular disease risk later in life.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/atvbaha.118.311017","type":"journal-article","created":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T09:16:55Z","timestamp":1531991815000},"page":"2236-2244","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":62,"title":["HDL (High-Density Lipoprotein) Metrics and Atherosclerotic Risk in Women"],"prefix":"10.1161","volume":"38","author":[{"given":"Samar R.","family":"El Khoudary","sequence":"first","affiliation":[{"name":"From the Department of Epidemiology, University of Pittsburgh, PA (S.R.E., S.S.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indre","family":"Ceponiene","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Los Angeles BioMedical Research Institute at Harbor UCLA Medical Center, Torrance, CA (I.C., D.L., M.J.B.)"},{"name":"Department of Cardiology, Lithuanian University of Health Sciences, Kaunas, Lithuania (I.C.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saad","family":"Samargandy","sequence":"additional","affiliation":[{"name":"From the Department of Epidemiology, University of Pittsburgh, PA (S.R.E., S.S.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James H.","family":"Stein","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison (J.H.S., M.C.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Los Angeles BioMedical Research Institute at Harbor UCLA Medical Center, Torrance, CA (I.C., D.L., M.J.B.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew C.","family":"Tattersall","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison (J.H.S., M.C.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Budoff","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Los Angeles BioMedical Research Institute at Harbor UCLA Medical Center, Torrance, CA (I.C., D.L., M.J.B.)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-006-0038-4"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2017.08.003"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.04.098"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/jech.56.suppl_1.i19"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2009.08.003"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e3181f6480e"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2007.03.045"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2016.04.008"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.109.190405"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2007.100586"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwf113"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.005669"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.016857"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(81)90253-8"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2008.113795"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03650411"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/18.6.499"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2011.05.013"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2010.155333"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2015.00218"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.816181"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbacli.2015.03.005"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)02636-X"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2017.284208"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-2144"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.15.2030"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M600167-JLR200"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0000000000000432"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad3517"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI25327"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.03.060"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.025678"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.002671"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-2-200901200-00006"}],"container-title":["Arteriosclerosis, 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