{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T18:15:15Z","timestamp":1785608115599,"version":"3.56.0"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec>\n            <jats:title>Objective\u2014<\/jats:title>\n            <jats:p>Lp(a) [lipoprotein(a)] levels vary by race\/ethnicity and were recently found to be associated with risk of heart failure (HF). We aimed to determine whether Lp(a)-related risk of HF is similar across different races and whether Lp(a) may further be related to HF with reduced ejection fraction or HF with preserved ejection fraction (HFpEF).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Approach and Results\u2014<\/jats:title>\n            <jats:p>\n              In 6809 participants of the MESA (Multi-Ethnic Study of Atherosclerosis), aged 45 to 84 years and free of cardiovascular disease, 308 incident HF events occurred during a median 13-year follow-up. Baseline Lp(a) concentrations were determined by immunoassay. Incident HF was adjudicated, distinguishing HF with reduced ejection fraction (ejection fraction, &lt;45%) from HFpEF (ejection fraction, \u226545%). Cox regression assessed relations between Lp(a) and HF risk among 4 races\/ethnicities. Lp(a) was examined as a continuous variable (per log unit) and using clinical cutoff values, 30 and 50 mg\/dL. Lp(a) was related to greater risk of HF in whites alone: per log unit Lp(a) (hazard ratio [HR], 1.20;\n              <jats:italic>P<\/jats:italic>\n              =0.02); Lp(a) \u226530 mg\/dL (HR, 1.69;\n              <jats:italic>P<\/jats:italic>\n              =0.01), Lp(a) \u226550 mg\/dL (HR, 1.87;\n              <jats:italic>P<\/jats:italic>\n              =0.006). No significant relations were found in black, Hispanic, or Chinese participants, and significant race interactions were observed. Lp(a) was additionally related to greater risk of HFpEF in white participants: per log unit Lp(a) (HR, 1.48;\n              <jats:italic>P<\/jats:italic>\n              =0.001), Lp(a) \u226530 mg\/dL (HR, 2.15;\n              <jats:italic>P<\/jats:italic>\n              =0.01), Lp(a) \u226550 mg\/dL (HR, 2.60;\n              <jats:italic>P<\/jats:italic>\n              =0.004). Lp(a)-related risk of HF and HFpEF in whites was independent of aortic valve disease.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>In a multiethnic sample, Lp(a)-related risks of HF and HFpEF were only evident in white participants. If confirmed, these findings have implications in further Lp(a) research and clinical practice.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/atvbaha.118.311220","type":"journal-article","created":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T13:52:45Z","timestamp":1538056365000},"page":"2498-2504","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":60,"title":["Lp(a) [Lipoprotein(a)]-Related Risk of Heart Failure Is Evident in Whites but Not in Other Racial\/Ethnic Groups"],"prefix":"10.1161","volume":"38","author":[{"given":"Brian T.","family":"Steffen","sequence":"first","affiliation":[{"name":"From the Department of Laboratory Medicine and Pathology (B.T.S., M.Y.T.), University of Minnesota, Minneapolis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Duprez","sequence":"additional","affiliation":[{"name":"Department of Medicine (D.D.), University of Minnesota, Minneapolis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain G.","family":"Bertoni","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC (A.G.B.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Guan","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, University of Minnesota School of Public Health, Minneapolis (W.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Y.","family":"Tsai","sequence":"additional","affiliation":[{"name":"From the Department of Laboratory Medicine and Pathology (B.T.S., M.Y.T.), University of Minnesota, Minneapolis"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000350"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12005"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000485"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/2048004014548735"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2003.025270"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.113.000400"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1109034"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2015.08.006"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2017.05.014"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.045120"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.115.306683"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.304785"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2016.270751"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwf113"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.03.060"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2007.12.038"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/46.12.1956"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.007885"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.598086"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2003.12.007"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1063"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.11.014"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R051904"}],"container-title":["Arteriosclerosis, Thrombosis, and Vascular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/ATVBAHA.118.311220","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T23:08:28Z","timestamp":1715555308000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/ATVBAHA.118.311220"}},"subtitle":["The Multi-Ethnic Study of Atherosclerosis"],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":23,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1161\/ATVBAHA.118.311220"],"URL":"https:\/\/doi.org\/10.1161\/atvbaha.118.311220","relation":{},"ISSN":["1079-5642","1524-4636"],"issn-type":[{"value":"1079-5642","type":"print"},{"value":"1524-4636","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"2018-04-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}