{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T08:02:24Z","timestamp":1781596944051,"version":"3.54.5"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec>\n            <jats:title>Objective\u2014<\/jats:title>\n            <jats:p>It is known that specific plasma ceramides are associated with stress-induced reversible myocardial perfusion defects in patients with established or suspected coronary artery disease undergoing myocardial perfusion scintigraphy (MPS). However, it is currently uncertain whether plasma ceramides are also associated with reduced poststress myocardial perfusion in these patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Approach and Results\u2014<\/jats:title>\n            <jats:p>\n              We measured 6 previously identified high-risk plasma ceramide species (ceramide [d18:1\/16:0], ceramide [d18:1\/18:0], ceramide [d18:1\/20:0], ceramide [d18:1\/22:0], ceramide [d18:1\/24:0], and ceramide [d18:1\/24:1]) in 167 consecutive patients with established or suspected coronary artery disease undergoing stress MPS for clinical indications. Plasma ceramides were measured by a targeted liquid chromatography\u2013tandem mass spectrometry assay both at baseline and after MPS. Multivariable linear regression analysis was undertaken to examine the associations (standardized B coefficients) between plasma ceramides and the percentage of poststress myocardial perfusion after adjustment for multiple cardiovascular risk factors. Seventy-eight patients had stress-induced myocardial ischemia on MPS (mainly located in the anteroapical wall). Of the 6 measured plasma ceramides, higher levels of basal ceramide (d18:1\/18:0; B=\u22120.182;\n              <jats:italic>P<\/jats:italic>\n              =0.019), ceramide (d18:1\/20:0; B=\u22120.224;\n              <jats:italic>P<\/jats:italic>\n              =0.004), ceramide (d18:1\/22:0; B=\u22120.163;\n              <jats:italic>P<\/jats:italic>\n              =0.035), and ceramide (d18:1\/24:1; B=\u22120.20;\n              <jats:italic>P<\/jats:italic>\n              =0.010) were associated with lower poststress anteroapical wall perfusion. Notably, these significant associations persisted even after adjustment for conventional cardiovascular risk factors, previous coronary artery disease, electrocardiographic left bundle branch block, left ventricular ejection fraction and type of stress testing. Similar results were observed for poststress plasma ceramides.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Higher circulating levels of specific ceramides, both at baseline and after stress, were independently associated with lower poststress anteroapical wall perfusion in patients with suspected or established coronary artery disease referred for clinically indicated MPS.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/atvbaha.118.311927","type":"journal-article","created":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T07:06:39Z","timestamp":1539327999000},"page":"2854-2861","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":37,"title":["Association of Plasma Ceramides With Myocardial Perfusion in Patients With Coronary Artery Disease Undergoing Stress Myocardial Perfusion Scintigraphy"],"prefix":"10.1161","volume":"38","author":[{"given":"Alessandro","family":"Mantovani","sequence":"first","affiliation":[{"name":"From the Section of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Italy (A.M., G.T.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Bonapace","sequence":"additional","affiliation":[{"name":"Division of Cardiology (S.B., C.D., E.B.), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Sacro Cuore - Don Calabria Hospital, Negrar (VR), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluigi","family":"Lunardi","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology (G.L., S.G.), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Sacro Cuore - Don Calabria Hospital, Negrar (VR), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Salgarello","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine (M.S.), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Sacro Cuore - Don Calabria Hospital, Negrar (VR), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clementina","family":"Dugo","sequence":"additional","affiliation":[{"name":"Division of Cardiology (S.B., C.D., E.B.), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Sacro Cuore - Don Calabria Hospital, Negrar (VR), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Gori","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology (G.L., S.G.), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Sacro Cuore - Don Calabria Hospital, Negrar (VR), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Barbieri","sequence":"additional","affiliation":[{"name":"Division of Cardiology (S.B., C.D., E.B.), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Sacro Cuore - Don Calabria Hospital, Negrar (VR), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Verlato","sequence":"additional","affiliation":[{"name":"Unit of Epidemiology and Medical Statistics, Department of Medicine and Public Health, University of Verona, Italy (G.V.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reijo","family":"Laaksonen","sequence":"additional","affiliation":[{"name":"Finnish Cardiovascular Research Center Tampere, University of Tampere, Faculty of Medicine and Life Sciences and Tampere University Hospital, Finland (R.L.)"},{"name":"Zora Biosciences Oy, Espoo, Finland (R.L.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Byrne","sequence":"additional","affiliation":[{"name":"Southampton National Institute for Health Research Biomedical Research Centre, University Hospital Southampton, Southampton General Hospital, United Kingdom (C.D.B.)"},{"name":"Nutrition and Metabolism, University of Southampton, United Kingdom (C.D.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Targher","sequence":"additional","affiliation":[{"name":"From the Section of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Italy (A.M., 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