{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:04:16Z","timestamp":1790741056339,"version":"4.1.0"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec>\n            <jats:title>Objective\u2014<\/jats:title>\n            <jats:p>Mechanisms of early and late improvements in cardiovascular risk after bariatric surgery and applicability to larger, at-risk populations remain unclear. We aimed to identify proteins altered after bariatric surgery and their relations to metabolic syndrome and diabetes mellitus.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Approach and Results\u2014<\/jats:title>\n            <jats:p>\n              We identified 19 proteins altered in 32 nonfasting plasma samples from a study of patients undergoing bariatric surgery who were evaluated preoperatively (visit 1) versus both early (visit 2; \u22483 months) and late (visit 3; \u224812 months) postoperative follow-up using predefined protein panels (Olink). Using in silico methods and publicly available gene expression repositories, we found that genes encoding 8 out of 19 proteins had highest expression in liver relative to other assayed tissues, with the top biological and disease processes, including major obesity-related vascular diseases. Of 19 candidate proteins in the surgical cohort, 6 were previously measured in &gt;3000 FHS (Framingham Heart Study) participants (IGFBP [insulin-like growth factor binding protein]-1, IGFBP-2, P-selectin, CD163, LDL (low-density lipoprotein)-receptor, and PAI [plasminogen activator inhibitor]-1). A higher concentration of IGFBP-2 at baseline was associated with a lower risk of incident metabolic syndrome (odds ratio per log-normal unit, 0.45; 95% CI, 0.32\u20130.64;\n              <jats:italic>P<\/jats:italic>\n              =7.7\u00d710\n              <jats:sup>-6<\/jats:sup>\n              ) and diabetes mellitus (odds ratio, 0.63; 95% CI, 0.49\u20130.79;\n              <jats:italic>P<\/jats:italic>\n              =0.0001) after multivariable adjustment.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Using a directed protein quantification platform (Olink), we identified known and novel proteins altered after surgical weight loss, including IGFBP-2. Future efforts in well-defined obesity intervention settings may further define and validate novel targets for the prevention of vascular disease in obesity.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/atvbaha.118.311928","type":"journal-article","created":{"date-parts":[[2018,12,26]],"date-time":"2018-12-26T19:00:23Z","timestamp":1545850823000},"page":"107-115","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":29,"title":["Proteins Altered by Surgical Weight Loss Highlight Biomarkers of Insulin Resistance in the Community"],"prefix":"10.1161","volume":"39","author":[{"given":"Ravi V.","family":"Shah","sequence":"first","affiliation":[{"name":"From the Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston (R.V.S., A.Y., J.H.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Jen","family":"Hwang","sequence":"additional","affiliation":[{"name":"Framingham Heart Study of the National Heart, Lung, and Blood Institute, MA (S.-J.H., C.Y., D.L.)"},{"name":"Population Sciences Branch of the National Heart, Lung, and Blood Institute of the National Institutes of Health, Bethesda, MD (S.-J.H., C.Y., D.L.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Yeri","sequence":"additional","affiliation":[{"name":"From the Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston (R.V.S., A.Y., J.H.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kahraman","family":"Tanriverdi","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Massachusetts at Worcester (K.T., O.V., J.E.F.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander R.","family":"Pico","sequence":"additional","affiliation":[{"name":"Data Science and Biotechnology, Gladstone Institutes, San Francisco, CA (A.R.P.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Yao","sequence":"additional","affiliation":[{"name":"Framingham Heart Study of the National Heart, Lung, and Blood Institute, MA (S.-J.H., C.Y., D.L.)"},{"name":"Population Sciences Branch of the National Heart, Lung, and Blood Institute of the National Institutes of Health, Bethesda, MD (S.-J.H., C.Y., D.L.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkatesh","family":"Murthy","sequence":"additional","affiliation":[{"name":"Department of Medicine and Radiology, University of Michigan at Ann Arbor (V.M.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Ho","sequence":"additional","affiliation":[{"name":"From the Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston (R.V.S., A.Y., J.H.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Vitseva","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Massachusetts at Worcester (K.T., O.V., J.E.F.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Demarco","sequence":"additional","affiliation":[{"name":"Department of Surgery, Tufts University, Boston, MA (D.D., S.S., M.D.I.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sajani","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Surgery, Tufts University, Boston, MA (D.D., S.S., M.D.I.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark D.","family":"Iafrati","sequence":"additional","affiliation":[{"name":"Department of Surgery, Tufts University, Boston, MA (D.D., S.S., 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