{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:07:54Z","timestamp":1787069274770,"version":"build-2736575974"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The chemokine CXCL16 (C-X-C motif ligand 16) is a scavenger receptor for OxLDL (oxidized low-density lipoproteins) and involved in inflammation at sites of atherosclerosis. This study aimed to investigate the association of CXCL16 with clinical outcome in patients with acute coronary syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Approach and Results:<\/jats:title>\n                    <jats:p>\n                      Serial measurements of CXCL16 were performed in a subgroup of 5142 patients randomized in the PLATO trial (Platelet Inhibition and Patient Outcome). Associations between CXCL16 and a composite of cardiovascular death, spontaneous myocardial infarction or stroke, and the individual components were assessed by multivariable Cox regression analyses. The hazard ratio per 50% increase in admission levels of CXCL16 analyzed as continuous variable was 1.64 (95% CI, 1.44\u20131.88),\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.0001. This association remained statistically significant after adjustment for randomized treatment, clinical variables, CRP (C-reactive protein), leukocytes, cystatin C, NT-proBNP (N-terminal pro-brain natriuretic peptide), troponin T, GDF-15 (growth differentiation factor 15), and other biomarkers; hazard ratio 1.23 (1.05\u20131.45),\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.0126. The admission level of CXCL16 was independently associated with cardiovascular death (1.50 [1.17\u20131.92],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.0014) but not with ischemic events alone, in fully adjusted analyses. No statistically independent association was found between CXCL16 measured at 1 month, or change in CXCL16 from admission to 1 month, and clinical outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In patients with acute coronary syndrome, admission level of CXCL16 is independently related to adverse clinical outcomes, mainly driven by an association to cardiovascular death. Thus, CXCL16 measurement may enhance risk stratification in patients with this condition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial Registration:<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      . Unique identifier: NCT00391872\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/atvbaha.119.312633","type":"journal-article","created":{"date-parts":[[2019,9,26]],"date-time":"2019-09-26T15:22:35Z","timestamp":1569511355000},"page":"2402-2410","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":32,"title":["C-X-C Ligand 16 Is an Independent Predictor of Cardiovascular Death and Morbidity in Acute Coronary Syndromes"],"prefix":"10.1161","volume":"39","author":[{"given":"Thomas","family":"Andersen","sequence":"first","affiliation":[{"name":"From the Department of Anaesthesiology, Stavanger University Hospital, Norway (T.A.)"},{"name":"Department of Clinical Science (K2), University of Bergen, Norway (T.A.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thor","family":"Ueland","sequence":"additional","affiliation":[{"name":"Research Institute of Internal Medicine, the National Hospital (T.U., P.A., A.E.M.), University of Oslo, Norway"},{"name":"K.G. Jebsen Inflammatory Research Centre (T.U., P.A.), University of Oslo, Norway"},{"name":"Faculty of Medicine (T.U., P.A., A.E.M), University of Oslo, Norway"},{"name":"K.G. Jebsen \u2013 Thrombosis Research and Expertise Centre (TREC), University of Troms\u00f8, Norway (T.U., P.A.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatevik","family":"Ghukasyan Lakic","sequence":"additional","affiliation":[{"name":"Uppsala Clinical Research Centre (T.G.L., A.\u00c5., M.B., S.K.J., L.W.), Uppsala University, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"\u00c5kerblom","sequence":"additional","affiliation":[{"name":"Uppsala Clinical Research Centre (T.G.L., A.\u00c5., M.B., S.K.J., L.W.), Uppsala University, Sweden"},{"name":"Department of Medical Sciences, Cardiology (A.\u00c5., S.K.J., L.W.), Uppsala University, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Bertilsson","sequence":"additional","affiliation":[{"name":"Uppsala Clinical Research Centre (T.G.L., A.\u00c5., M.B., S.K.J., L.W.), Uppsala University, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e5l","family":"Aukrust","sequence":"additional","affiliation":[{"name":"Research Institute of Internal Medicine, the National Hospital (T.U., P.A., A.E.M.), University of Oslo, Norway"},{"name":"K.G. 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Jebsen \u2013 Thrombosis Research and Expertise Centre (TREC), University of Troms\u00f8, Norway (T.U., P.A.)"},{"name":"Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital, Rikshospitalet, Norway (P.A.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika E.","family":"Michelsen","sequence":"additional","affiliation":[{"name":"Research Institute of Internal Medicine, the National Hospital (T.U., P.A., A.E.M.), University of Oslo, Norway"},{"name":"Faculty of Medicine (T.U., P.A., A.E.M), University of Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan K.","family":"James","sequence":"additional","affiliation":[{"name":"Uppsala Clinical Research Centre (T.G.L., A.\u00c5., M.B., S.K.J., L.W.), Uppsala University, Sweden"},{"name":"Department of Medical Sciences, Cardiology (A.\u00c5., S.K.J., L.W.), Uppsala University, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard C.","family":"Becker","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Health and Disease, Heart, Lung and Vascular Institute, University of Cincinnati College of Medicine, OH (R.C.B.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F.","family":"Storey","sequence":"additional","affiliation":[{"name":"Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, United Kingdom (R.F.S.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Wallentin","sequence":"additional","affiliation":[{"name":"Uppsala Clinical Research Centre (T.G.L., A.\u00c5., M.B., S.K.J., L.W.), Uppsala University, Sweden"},{"name":"Department of Medical Sciences, Cardiology (A.\u00c5., S.K.J., L.W.), Uppsala University, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agneta","family":"Siegbahn","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Clinical Chemistry (A.S.), Uppsala University, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Kontny","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Stavanger University Hospital, Norway (F.K.)"},{"name":"Drammen Heart Centre, Norway (F.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the PLATO Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv320"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(02)02953-4"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.306656"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1707914"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000145167.30987.2E"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.112.300326"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2014.04.002"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2017.06.008"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn071"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.108.821074"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH10-10-0689"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH14-11-0911"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.276444"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2017.09.013"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.5551\/jat.29942"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2005.01469.x"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.11.004"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.220558"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.5551\/jat.24299"},{"key":"e_1_3_4_21_2","first-page":"3138","article-title":"PPARG, AGTR1, CXCL16 and LGALS2 polymorphisms are correlated with the risk for coronary heart disease","volume":"8","author":"Tian J","year":"2015","unstructured":"Tian, J, Hu, S, Wang, F, Yang, X, Li, Y, Huang, C. 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