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However, the pathological manifestations of peripheral artery disease result from thrombosis regardless of the extent of atherosclerosis. Approximately 75% of peripheral arteries with significant stenosis demonstrate presence of thrombi, of which two-thirds have thrombi associated with insignificant atherosclerosis. The presence of obliterative thrombi in peripheral arteries of patients with critical limb ischemia in the absence of coronary artery\u2013like lesions suggests a locally thrombogenic or remotely embolic basis of disease. Extensive calcification of the medial vascular layer is commonly observed. In this review, we have described and compared the pathological basis of coronary and peripheral artery disease in patients with acute coronary syndrome and critical limb ischemia. It is expected that pathogenetic characterization would allow for definition of strategic targets for superior management of peripheral artery disease.<\/jats:p>","DOI":"10.1161\/atvbaha.119.312864","type":"journal-article","created":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T05:00:28Z","timestamp":1594875628000},"page":"1982-1989","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":133,"title":["Pathologic Disparities Between Peripheral Artery Disease and Coronary Artery Disease"],"prefix":"10.1161","volume":"40","author":[{"given":"Nupoor","family":"Narula","sequence":"first","affiliation":[{"name":"From the Division of Cardiology\/Department of Medicine, New York Presbyterian Hospital\/Weill Cornell Medicine (Nupoor Narula)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey W.","family":"Olin","sequence":"additional","affiliation":[{"name":"The Zena and Michael A. 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