{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:15:23Z","timestamp":1791256523224,"version":"4.1.0"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:p>Targeted oncology therapies have revolutionized cancer treatment over the last decade and have resulted in improved prognosis for many patients. This advance has emanated from elucidation of pathways responsible for tumorigenesis followed by targeting of these pathways by specific molecules. Cardiovascular care has become an increasingly critical aspect of patient care in part because patients live longer, but also due to potential associated toxicities from these therapies. Because of the targeted nature of cancer therapies, cardiac and vascular side effects may additionally provide insights into the basic biology of vascular disease. We herein provide the example of tyrosine kinase inhibitors utilized in chronic myelogenous leukemia to illustrate this medical transformation. We describe the vascular considerations for the clinical care of chronic myelogenous leukemia patients as well as the emerging literature on mechanisms of toxicities of the individual tyrosine kinase inhibitors. We additionally postulate that basic insights into toxicities of novel cancer therapies may serve as a new platform for investigation in vascular biology and a new translational research opportunity in vascular medicine.<\/jats:p>","DOI":"10.1161\/atvbaha.119.313353","type":"journal-article","created":{"date-parts":[[2019,12,26]],"date-time":"2019-12-26T05:00:33Z","timestamp":1577336433000},"page":"301-308","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":64,"title":["Tyrosine Kinase Inhibitors in Leukemia and Cardiovascular Events"],"prefix":"10.1161","volume":"40","author":[{"given":"Ali","family":"Manouchehri","sequence":"first","affiliation":[{"name":"From the Cardio-Oncology Program, Department of Medicine (A.M., E.K., J.M.), Vanderbilt University Medical Center, Nashville, TN"},{"name":"Division of Clinical Pharmacology, Department of Medicine (A.M.), Vanderbilt University Medical Center, Nashville, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elishama","family":"Kanu","sequence":"additional","affiliation":[{"name":"From the Cardio-Oncology Program, Department of Medicine (A.M., E.K., J.M.), Vanderbilt University Medical Center, Nashville, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Mauro","sequence":"additional","affiliation":[{"name":"Myeloproliferative Neoplasms Program, Leukemia Service, Department of Hematology Oncology, Memorial Sloan Kettering Cancer Center, New York (M.J.M.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron W.","family":"Aday","sequence":"additional","affiliation":[{"name":"Vanderbilt Translational and Clinical Cardiovascular Research Center, Department of Medicine (A.W.A.), Vanderbilt University Medical Center, Nashville, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan R.","family":"Lindner","sequence":"additional","affiliation":[{"name":"Knight Cardiovascular Institute, Oregon Health &amp; Science University, Portland (J.R.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javid","family":"Moslehi","sequence":"additional","affiliation":[{"name":"From the Cardio-Oncology Program, Department of Medicine (A.M., E.K., J.M.), Vanderbilt University Medical Center, Nashville, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3297"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2015.04.005"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2015.07.008"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0092146"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.62.4718"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2015.07.010"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2012.12.009"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","unstructured":"Mauro MJ Flinn I Hare TO Hu S Narasimhan NI Rivera VM Clackson T Turner CD Haluska FG Druker BJ et al. Ponatinib in refractory Philadelphia chromosome\u2013positive leukemias. N Engl J Med. 2012;367:2075\u20132088. doi: 10.1056\/NEJMoa1205127","DOI":"10.1056\/NEJMoa1205127"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","unstructured":"Cortes JE Kim D Pinilla-ibarz J Coutre PD Paquette R Chuah C Nicolini FE Apperley JF Khoury HJ Talpaz M et al. Ponatinib efficacy and safety in Philadelphia chromosome \u2013 positive leukemia: final 5-year results of the phase 2 PACE trial. Blood. 2019;132:393\u2013405. doi: 10.1182\/blood-2016-09-739086","DOI":"10.1182\/blood-2016-09-739086"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000000412"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.079921"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.134"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2016.5"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.64.8899"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2017.05.005"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2017.245"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2016.07.019"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.104075"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2018.00055"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-012-1222-7"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.306884"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2012.04.005"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2018.1780"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.70"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61576-7"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.10271"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-10-881557"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0145937"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI86249"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00537"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1100265"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature21702"}],"container-title":["Arteriosclerosis, Thrombosis, and Vascular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/ATVBAHA.119.313353","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T18:45:53Z","timestamp":1715539553000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/ATVBAHA.119.313353"}},"subtitle":["From Mechanism to Patient Care"],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1161\/ATVBAHA.119.313353"],"URL":"https:\/\/doi.org\/10.1161\/atvbaha.119.313353","relation":{},"ISSN":["1079-5642","1524-4636"],"issn-type":[{"value":"1079-5642","type":"print"},{"value":"1524-4636","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"2019-08-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}