{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T05:26:26Z","timestamp":1780464386216,"version":"3.54.1"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n            <jats:title>Objective:<\/jats:title>\n            <jats:p>Inducible myocardial ischemia is influenced by contributions of both the epicardial artery and the coronary microcirculation. Experimental studies have found adverse microcirculatory remodeling to occur downstream of severe coronary stenoses. Coronary physiology studies in patients contradict the experimental findings, as the minimal microvascular resistance is not modified by stenoses. The objective was to determine whether microcirculatory remodeling occurs downstream of coronary stenoses in the human coronary circulation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Approach and Results:<\/jats:title>\n            <jats:p>Myocardium corresponding to 115 coronary arteries of 55 deceased patients was investigated. Histopathologic staining of the microcirculation was performed using antibodies against SMA-\u03b1 (smooth muscle actin-\u03b1) and CD31, to stain arterioles and capillaries, respectively. The following parameters were analyzed: ratio between lumen and vesel area, ratio between lumen and vessel diameter (both ratios for arterioles of &lt;40, 40\u2013100, and 100\u2013200 \u00b5m diameter), arteriolar density, and capillary density. From the 55 patients, 32 pairs of an unobstructed coronary artery and a coronary artery with a stenosis were formed. No statistically significant differences between any of the microcirculatory parameters were found. A confirmatory unpaired analysis compared 3 groups: (1) coronary arteries in patients without coronary artery disease (n=53), (2) unobstructed coronary arteries in patients with a stenosis in one of the other coronary arteries (n=23), and (3) coronary stenoses (n=39). No statistically significant differences were observed between the groups.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>The microcirculation distal to noncritical stenoses does not undergo structural remodeling in the human coronary circulation.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/atvbaha.119.313462","type":"journal-article","created":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T09:05:31Z","timestamp":1572512731000},"page":"230-238","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Downstream Influence of Coronary Stenoses on Microcirculatory Remodeling"],"prefix":"10.1161","volume":"40","author":[{"given":"Guus A.","family":"de Waard","sequence":"first","affiliation":[{"name":"From the Department of Cardiology (G.A.d.W., M.R.H., D.R., T.t.B.H., R.M., N.W.v.d.H., N.v.R.), VU University Medical Center, Amsterdam, The Netherlands"},{"name":"Amsterdam Cardiovascular Sciences, The Netherlands (G.A.d.W., M.R.H., N.W.v.d.H., H.W.N.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurits R.","family":"Hollander","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (G.A.d.W., M.R.H., D.R., T.t.B.H., R.M., N.W.v.d.H., N.v.R.), VU University Medical Center, Amsterdam, The Netherlands"},{"name":"Amsterdam Cardiovascular Sciences, The Netherlands (G.A.d.W., M.R.H., N.W.v.d.H., H.W.N.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danique","family":"Ruiter","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (G.A.d.W., M.R.H., D.R., T.t.B.H., R.M., N.W.v.d.H., N.v.R.), VU University Medical Center, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"ten Bokkel Huinink","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (G.A.d.W., M.R.H., D.R., T.t.B.H., R.M., N.W.v.d.H., N.v.R.), VU University Medical Center, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Meer","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (G.A.d.W., M.R.H., D.R., T.t.B.H., R.M., N.W.v.d.H., N.v.R.), VU University Medical Center, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina W.","family":"van der Hoeven","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (G.A.d.W., M.R.H., D.R., T.t.B.H., R.M., N.W.v.d.H., N.v.R.), VU University Medical Center, Amsterdam, The Netherlands"},{"name":"Amsterdam Cardiovascular Sciences, The Netherlands (G.A.d.W., M.R.H., N.W.v.d.H., H.W.N.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Meinster","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cardiac Surgery (E.M., J.A.M.B., H.W.N.), VU University Medical Center, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen A.M.","family":"Beli\u00ebn","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cardiac Surgery (E.M., J.A.M.B., H.W.N.), VU University Medical Center, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans W.","family":"Niessen","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cardiac Surgery (E.M., J.A.M.B., H.W.N.), VU University Medical Center, Amsterdam, The Netherlands"},{"name":"Amsterdam Cardiovascular Sciences, The Netherlands (G.A.d.W., M.R.H., N.W.v.d.H., H.W.N.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"van Royen","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (G.A.d.W., M.R.H., D.R., T.t.B.H., R.M., N.W.v.d.H., N.v.R.), VU University Medical Center, 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