{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:43:51Z","timestamp":1790862231649,"version":"4.1.0"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n            <jats:title>Objective:<\/jats:title>\n            <jats:p>Takotsubo syndrome (TTS) is characterized by acute left ventricular dysfunction, which can contribute to intraventricular thrombus and embolism. Still, prevalence and clinical impact of thrombus formation and embolic events on outcome of TTS patients remain unclear. This study aimed to investigate clinical features and outcomes of patients with and without intraventricular thrombus or embolism. Additionally, factors associated with thrombus formation or embolism, as well as predictors for mortality, were identified.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Approach and Results:<\/jats:title>\n            <jats:p>\n              TTS patients enrolled in the International Takotsubo Registry at 28 centers in Australia, Europe, and the United States were dichotomized according to the occurrence\/absence of intraventricular thrombus or embolism. Patients with intraventricular thrombus or embolism were defined as the ThrombEmb group. Of 1676 TTS patients, 56 (3.3%) patients developed intraventricular thrombus and\/or embolism following TTS diagnosis (median time interval, 2.0 days [range, 0\u201338 days]). Patients in the ThrombEmb group had a different clinical profile including lower left ventricular ejection fraction, higher prevalence of the apical type, elevated levels of troponin and inflammatory markers, and higher prevalence of vascular disease. In a Firth bias-reduced penalized-likelihood logistic regression model apical type, left ventricular ejection fraction \u226430%, previous vascular disease, and a white blood cell count on admission &gt;10\u00d710\n              <jats:sup>3<\/jats:sup>\n              cells\/\u03bcL emerged as independent predictors for thrombus formation or embolism.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Intraventricular thrombus or embolism occur in 3.3% of patients in the acute phase of TTS. A simple risk score including clinical parameters associated with intraventricular thrombus formation or embolism identifies patients at increased risk.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration:<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT01947621.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/atvbaha.119.313491","type":"journal-article","created":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T10:00:23Z","timestamp":1574762423000},"page":"279-287","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":66,"title":["Intraventricular Thrombus Formation and Embolism in Takotsubo Syndrome"],"prefix":"10.1161","volume":"40","author":[{"given":"Katharina J.","family":"Ding","sequence":"first","affiliation":[{"name":"From the Department of Cardiology, University Heart Center, University Hospital Zurich, Switzerland (K.J.D., V.L.C., K.A.S., B.E.S., D.D.V., F.R., J.R.G., C. Templin)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria L.","family":"Cammann","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, University Heart Center, University Hospital Zurich, Switzerland (K.J.D., V.L.C., K.A.S., B.E.S., D.D.V., F.R., J.R.G., C. Templin)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konrad A.","family":"Szawan","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, University Heart Center, University Hospital Zurich, Switzerland (K.J.D., V.L.C., K.A.S., B.E.S., D.D.V., F.R., J.R.G., C. Templin)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara E.","family":"St\u00e4hli","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, University Heart Center, University Hospital Zurich, Switzerland (K.J.D., V.L.C., K.A.S., B.E.S., D.D.V., F.R., J.R.G., C. Templin)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Wischnewsky","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Computer Science, University of Bremen, Germany (M.W.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Di Vece","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, University Heart Center, University Hospital Zurich, Switzerland (K.J.D., V.L.C., K.A.S., B.E.S., D.D.V., F.R., J.R.G., C. Templin)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"Citro","sequence":"additional","affiliation":[{"name":"Heart Department, University Hospital \u201cSan Giovanni di Dio e Ruggi d\u2019Aragona\u201d, Salerno, Italy (R.C.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milosz","family":"Jaguszewski","sequence":"additional","affiliation":[{"name":"First Department of Cardiology, Medical University of Gdansk, Poland (M.J.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burkhardt","family":"Seifert","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Switzerland (B.S.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annahita","family":"Sarcon","sequence":"additional","affiliation":[{"name":"Section of Cardiac Electrophysiology, Department of Medicine, University of California-San Francisco (A. 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Christian","family":"Napp","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology, Hannover Medical School, Germany (L.C.N., J.B.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Franke","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heidelberg University Hospital, Germany (J.F., H.A.K.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Noutsias","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Division of Cardiology, Angiology and Intensive Medical Care, University Hospital Halle, Martin-Luther-University Halle, Germany (M. Noutsias)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christof","family":"Burgdorf","sequence":"additional","affiliation":[{"name":"Heart and Vascular center Bad Bevensen, Germany (C. 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Karakas)"},{"name":"German Centre for Cardiovascular Research, Partner Site Hamburg\/Kiel\/Luebeck (M. Karakas)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Pott","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II\u2013Cardiology, University of Ulm, Medical Center, Germany (A. Pott, W.R.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Meyer","sequence":"additional","affiliation":[{"name":"Service de cardiologie, H\u00f4pitaux Universitaires de Gen\u00e8ve, Switzerland (P. Meyer, J.D.A.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose D.","family":"Arroja","sequence":"additional","affiliation":[{"name":"Service de cardiologie, H\u00f4pitaux Universitaires de Gen\u00e8ve, Switzerland (P. 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Borggrefe)"},{"name":"German Center for Cardiovascular Research, Partner Site, Heidelberg-Mannheim (I.E.-B., I.A., M. Borggrefe)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Akin","sequence":"additional","affiliation":[{"name":"First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim, University of Heidelberg, Germany (I.E.-B., I.A., M. Borggrefe)"},{"name":"German Center for Cardiovascular Research, Partner Site, Heidelberg-Mannheim (I.E.-B., I.A., M. Borggrefe)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Gilyarova","sequence":"additional","affiliation":[{"name":"Intensive Coronary Care Unit, Moscow City Hospital No. 1 named after N. Pirogov, Moscow, Russia (E.G., A. 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