{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T10:30:39Z","timestamp":1770460239251,"version":"3.49.0"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n            <jats:title>Background and Objective:<\/jats:title>\n            <jats:p>Peripheral artery disease (PAD) is the third most common form of atherosclerotic vascular disease and is characterized by significant functional disability and increased cardiovascular mortality. Recent genetic data support a role for a procoagulation protein variant, the factor V Leiden mutation, in PAD. The role of other hemostatic factors in PAD remains unknown. We evaluated the role of hemostatic factors in PAD using Mendelian randomization.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Approach and Results:<\/jats:title>\n            <jats:p>\n              Two-sample Mendelian randomization to evaluate the roles of FVII (factor VII), FVIII (factor VIII), FXI (factor XI), VWF (von Willebrand factor), and fibrinogen in PAD was performed using summary statistics from GWAS for hemostatic factors performed within the Cohorts for Heart and Aging Research in the Genome Epidemiology Consortium and from GWAS performed for PAD within the Million Veteran Program. Genetically determined FVIII and VWF, but not FVII, FXI, or fibrinogen, were associated with PAD in Mendelian randomization experiments (FVIII: odds ratio, 1.41 [95% CI, 1.23\u20131.62],\n              <jats:italic>P<\/jats:italic>\n              =6.0\u00d710\n              <jats:sup>\u22127<\/jats:sup>\n              , VWF: odds ratio, 1.28 [95% CI, 1.07\u20131.52],\n              <jats:italic>P<\/jats:italic>\n              =0.0073). In single variant sensitivity analysis, the\n              <jats:italic>ABO<\/jats:italic>\n              locus was the strongest genetic instrument for both FVIII and VWF.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Our results suggest a role for hemostasis, and by extension, thrombosis in PAD. Further study is warranted to determine whether VWF and FVIII independently affect the biology of PAD.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/atvbaha.119.313847","type":"journal-article","created":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T09:00:22Z","timestamp":1598518822000},"page":"380-386","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":26,"title":["Mendelian Randomization Analysis of Hemostatic Factors and Their Contribution to Peripheral Artery Disease\u2014Brief Report"],"prefix":"10.1161","volume":"41","author":[{"given":"Aeron M.","family":"Small","sequence":"first","affiliation":[{"name":"Corporal Michael J. Crescenz VA Medical Center, PA (A.M.S., K.-M.C., S.M.D.)."},{"name":"Department of Medicine, Yale University School of Medicine, New Haven, CT (A.M.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer E.","family":"Huffman","sequence":"additional","affiliation":[{"name":"Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), Boston VA Healthcare System (J.E.H., D.K., K.C., C.J.O.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4636-5780","authenticated-orcid":true,"given":"Derek","family":"Klarin","sequence":"additional","affiliation":[{"name":"Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), Boston VA Healthcare System (J.E.H., D.K., K.C., C.J.O.)."},{"name":"Department of Surgery, Massachusetts General Hospital, Boston (D.K.)."},{"name":"Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA (D.K.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0128-379X","authenticated-orcid":true,"given":"Maria","family":"Sabater-Lleal","sequence":"additional","affiliation":[{"name":"Genomics of Complex Diseases, Research Institute of Hospital Sant Pau, IIB Sant Pau, Barcelona, Spain (M.S.-L.)."},{"name":"Cardiovascular Medicine Unit, Department of Medicine, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden (M.S.-L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie A.","family":"Lynch","sequence":"additional","affiliation":[{"name":"Department of Veterans Affairs, Salt Lake City Health Care System, UT (J.A.L.)."},{"name":"University of Massachusetts College of Nursing &amp; 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