{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T22:41:50Z","timestamp":1788907310373,"version":"build-2803163510"},"reference-count":58,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec>\n            <jats:title>Objective:<\/jats:title>\n            <jats:p>Patients with psoriasis have impaired vascular health and increased cardiovascular disease (CVD). Platelets are key players in the pathogenesis of vascular dysfunction in cardiovascular disease and represent therapeutic targets in cardiovascular prevention. The object of this study was to define the platelet phenotype and effector cell properties on vascular health in psoriasis and evaluate whether aspirin modulates the platelet-induced phenotype.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Approach and Results:<\/jats:title>\n            <jats:p>\n              Platelets from psoriasis patients (n=45) exhibited increased platelet activation (relative to age- and gender-matched controls, n=18), which correlated with psoriasis skin severity. Isolated platelets from psoriasis patients demonstrated a 2- to 3-fold (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &lt;0.01) increased adhesion to human aortic endothelial cells and induced proinflammatory transcriptional changes, including upregulation of\n              <jats:italic toggle=\"yes\">IL 8<\/jats:italic>\n              (interleukin 8),\n              <jats:italic toggle=\"yes\">IL1\u03b2<\/jats:italic>\n              , and Cox (cyclooxygenase)-2 Platelet RNA sequencing revealed an interferon signature and elevated expression of\n              <jats:italic toggle=\"yes\">COX-1<\/jats:italic>\n              , which correlated with psoriasis disease severity (\n              <jats:italic toggle=\"yes\">r<\/jats:italic>\n              =0.83,\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.01). In a randomized trial of patients with psoriasis, 2 weeks of 81 mg low-dose aspirin, a COX-1 inhibitor, reduced serum thromboxane (Tx) B\n              <jats:sub>2<\/jats:sub>\n              and reduced brachial vein endothelial proinflammatory transcript expression &gt;70% compared with the no-treatment group (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &lt;0.01). Improvement in brachial vein endothelial cell inflammation significantly correlated with change in serum TxB\n              <jats:sub>2<\/jats:sub>\n              (\n              <jats:italic toggle=\"yes\">r<\/jats:italic>\n              =0.48,\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.02).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>In patients with psoriasis, platelets are activated and induce endothelial cell inflammation. Low-dose aspirin improved endothelial cell health in psoriasis via platelet COX-1 inhibition. These data demonstrate a previously unappreciated role of platelets in psoriasis and endothelial cell inflammation and suggests that aspirin may be effective in improving vascular health in patients with psoriasis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Registration:<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT03228017.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/atvbaha.119.314008","type":"journal-article","created":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T18:08:46Z","timestamp":1584554926000},"page":"1340-1351","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":83,"title":["Activated Platelets Induce Endothelial Cell Inflammatory Response in Psoriasis via COX-1"],"prefix":"10.1161","volume":"40","author":[{"given":"Michael S.","family":"Garshick","sequence":"first","affiliation":[{"name":"From the Department of Medicine, Center for the Prevention of Cardiovascular Disease (M.S.G., E.A.F., J.S.B.), New York University School of Medicine"},{"name":"Leon H. 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Charney Division of Cardiology, Department of Medicine (M.S.G., M.T., T.J.B., M.E., A.L., E.A.F., J.S.B.), New York University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charissa M.","family":"Salud-Gnilo","sequence":"additional","affiliation":[{"name":"Laboratory for Investigative Dermatology, Rockefeller University, New York (C.M.S.-G, J.G.K.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Eppler","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology, Department of Medicine (M.S.G., M.T., T.J.B., M.E., A.L., E.A.F., J.S.B.), New York University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Lee","sequence":"additional","affiliation":[{"name":"Leon H. 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