{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T12:29:15Z","timestamp":1764332955213,"version":"3.40.5"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec>\n            <jats:title>Objective:<\/jats:title>\n            <jats:p>Women with symptoms or signs of myocardial ischemia but no obstructive coronary artery disease (INOCA) often have coronary vascular dysfunction and elevated risk for adverse cardiovascular events. We hypothesized that u-hscTnI (ultra-high\u2013sensitivity cardiac troponin I), a sensitive indicator of ischemic cardiomyocyte injury, is associated with coronary vascular dysfunction in women with INOCA.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Approach and Results:<\/jats:title>\n            <jats:p>\n              Women (N=263) with INOCA enrolled in the WISE-CVD study (Women\u2019s Ischemic Syndrome Evaluation\u2013Coronary Vascular Dysfunction) underwent invasive coronary vascular function testing and u-hscTnI measurements (Simoa HD-1 Analyzer; Quanterix Corporation, Lexington, MA). Logistic regression models, adjusted for traditional cardiovascular risk factors were used to evaluate associations between u-hscTnI and coronary vascular function. Women with coronary vascular dysfunction (microvascular constriction and limited coronary epicardial dilation) had higher plasma u-hscTnI levels (both\n              <jats:italic>P<\/jats:italic>\n              =0.001). u-hscTnI levels were associated with microvascular constriction (odds ratio, 1.38 per doubling of u-hscTnI [95% CI, 1.03\u20131.84];\n              <jats:italic>P<\/jats:italic>\n              =0.033) and limited coronary epicardial dilation (odds ratio, 1.37 per doubling of u-hscTnI [95% CI, 1.04\u20131.81];\n              <jats:italic>P<\/jats:italic>\n              =0.026). u-hscTnI levels were not associated with microvascular dilation or coronary epicardial constriction.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Our findings indicate that higher u-hscTnI is associated with coronary vascular dysfunction in women with INOCA. This suggests that ischemic cardiomyocyte injury in the setting of coronary vascular dysfunction has the potential to contribute to adverse cardiovascular outcomes observed in these women. Additional studies are needed to confirm and investigate mechanisms underlying these findings in INOCA.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Registration:<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT00832702.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/atvbaha.120.314260","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T09:00:52Z","timestamp":1602147652000},"page":"3015-3021","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["Coronary Vascular Function and Cardiomyocyte Injury"],"prefix":"10.1161","volume":"40","clinical-trial-number":[{"clinical-trial-number":"nct00832702","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Ahmed","family":"AlBadri","sequence":"first","affiliation":[{"name":"Emory Clinical Cardiovascular Research Institute, Department of Medicine, Emory University School of Medicine, Atlanta, GA (A.A., P.K.M., Y.X., Y.-A.K.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet","family":"Wei","sequence":"additional","affiliation":[{"name":"Barbra Streisand Women\u2019s Heart Center, Cedars-Sinai Smidt Heart Institute, Los Angeles, CA (J.W., O.Q., B.A., B.S., T.D.H., J.V.E., C.N.B.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Odayme","family":"Quesada","sequence":"additional","affiliation":[{"name":"Barbra Streisand Women\u2019s Heart Center, Cedars-Sinai Smidt Heart Institute, Los Angeles, CA (J.W., O.Q., B.A., B.S., T.D.H., J.V.E., C.N.B.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Puja K.","family":"Mehta","sequence":"additional","affiliation":[{"name":"Emory Clinical Cardiovascular Research Institute, Department of Medicine, Emory University School of Medicine, Atlanta, GA (A.A., P.K.M., Y.X., Y.-A.K.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3816-461X","authenticated-orcid":true,"given":"Yi","family":"Xiao","sequence":"additional","affiliation":[{"name":"Emory Clinical Cardiovascular Research Institute, Department of Medicine, Emory University School of Medicine, Atlanta, GA (A.A., P.K.M., Y.X., Y.-A.K.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-An","family":"Ko","sequence":"additional","affiliation":[{"name":"Emory Clinical Cardiovascular Research Institute, Department of Medicine, Emory University School of Medicine, Atlanta, GA (A.A., P.K.M., Y.X., Y.-A.K.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. David","family":"Anderson","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville (R.D.A., J.P., E.M.H., C.J.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Petersen","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville (R.D.A., J.P., E.M.H., C.J.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Babak","family":"Azarbal","sequence":"additional","affiliation":[{"name":"Barbra Streisand Women\u2019s Heart Center, Cedars-Sinai Smidt Heart Institute, Los Angeles, CA (J.W., O.Q., B.A., B.S., T.D.H., J.V.E., C.N.B.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Samuels","sequence":"additional","affiliation":[{"name":"Barbra Streisand Women\u2019s Heart Center, Cedars-Sinai Smidt Heart Institute, Los Angeles, CA (J.W., O.Q., B.A., B.S., T.D.H., J.V.E., C.N.B.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1123-0533","authenticated-orcid":true,"given":"Timothy D.","family":"Henry","sequence":"additional","affiliation":[{"name":"Barbra Streisand Women\u2019s Heart Center, Cedars-Sinai Smidt Heart Institute, Los Angeles, CA (J.W., O.Q., B.A., B.S., T.D.H., J.V.E., C.N.B.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4088-6240","authenticated-orcid":true,"given":"Galen","family":"Cook-Wiens","sequence":"additional","affiliation":[{"name":"Biostatistics and Bioinformatics Research Center, Cedars-Sinai Medical Center, Los Angeles, CA (G.C.-W.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eileen M.","family":"Handberg","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville (R.D.A., J.P., E.M.H., C.J.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Van Eyk","sequence":"additional","affiliation":[{"name":"Barbra Streisand Women\u2019s Heart Center, Cedars-Sinai Smidt Heart Institute, Los Angeles, CA (J.W., O.Q., B.A., B.S., T.D.H., J.V.E., C.N.B.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6011-681X","authenticated-orcid":true,"given":"Carl J.","family":"Pepine","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville (R.D.A., J.P., E.M.H., C.J.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9933-5155","authenticated-orcid":true,"given":"C. 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